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Tse Wen Chang
Tse Wen Chang (, born August 25, 1947) is a Taiwanese immunologist. His early research involving the Immunoglobulin E (IgE) pathway and antibody-based therapeutics lead to the development of omalizumab (also known as Xolair), a medication that has been approved for the treatment of severe allergic asthma and severe chronic spontaneous urticaria. Chang is a cofounder of Tanox, a biopharmaceutical company specialized in anti-IgE therapies for the treatment of allergic diseases. After Tanox's tripartite partnership with Genentech and Novartis was made in 1996, Chang returned to his alma mater, the National Tsing Hua University in Taiwan and served as the Dean (1996–1999) of the College of Life Sciences. Chang was appointed by the Taiwanese government as President of the Development Center for Biotechnology (DCB) in 2000, and served as a Science and Technology Advisor of the Executive Yuan from 2002 to 2006. From 2006 to 2016, he was tenured as Distinguished Research Fellow at the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zhongli District
Zhongli District () is a District (Taiwan), district in Taoyuan City, Taiwan. Zhongli is spelled variously as ''Jungli'', ''Jongli'', ''Jhongli'' or ''Chungli'' on railway stations, bus stops and road signs. Historically, the city is the site of the Zhongli Incident of 1977, the most significant event of the democratization movement prior to the 1980s. Ethnically, it is considered a capital city for Hakka Taiwanese, who live in great numbers here and in surrounding areas; many elderly persons can speak Hakka Chinese, Hakka in addition to Standard Chinese, Mandarin and Taiwanese Hokkien. In recent years many foreign workers (mainly from the Overseas Filipino Worker, Philippines and Thailand) have also settled in and around the city due to the heavy industry in the suburbs of the city, making it a center for foreign laborers. The district of Zhongli has three large parks and over 70 green reserves. Zhongli District is the busiest district in Southern Taoyuan (南桃園), as well as t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Spontaneous Urticaria
Chronic spontaneous urticaria (CSU) also known as Chronic idiopathic urticaria (CIU) is defined by the presence of wheals, angioedema, or both for more than six weeks. The most common symptoms of chronic spontaneous urticaria are angioedema and hives that are accompanied by itchiness. Chronic spontaneous urticaria, despite its cause being unknown, is linked to a higher prevalence of autoimmune diseases, and is often worsened by triggers like stress, infections, certain foods, or nonsteroidal anti-inflammatory drugs. The hives and angioedema seen in CSU is thought to be linked to the degranulation of skin mast cells. Mast cells release proteases, histamine, cytokines, and arachidonic acid metabolites, causing swelling, redness, and itching. The standard workup for CSU differs in different parts of the world. However, most doctors agree on the importance of having a detailed history. The main goal is to identify any urticaria-inducing factors because eliminating them is the most st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Talizumab
Talizumab (TNX-901) is a humanized monoclonal antibody that was under development by Tanox in Houston, Texas as a new-concept therapeutic for allergic diseases. The unique anti-IgE antibody was designed to target immunoglobulin E (IgE) and IgE-expressing B lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils. Talizumab was tested in clinical trials at National Jewish Medical and Research Center and other medical centers and allergy clinics across the U. S. and shown to be able to prevent allergic reactions to accidental exposure to peanuts, which is contained in many kinds of foods. History The U.S. Food and Drug Administration (FDA) " fast-tracked" TNX-901. A drug is given a fast-track status if it meets a medical need not currently being met by any medication. TNX-901 was developed by Houston-based Tanox, started by two biomedical scientists, Nancy T. Chang and Tse Wen Chang, in 1986. There was a le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C). However, the agency also enforces other laws, notably Section 361 of the Public Health Service Act as well as associated regulations. Much of this regulatory-enforcement work is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology
The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and science. In response to the increasing Technological and industrial history of the United States, industrialization of the United States, William Barton Rogers organized a school in Boston to create "useful knowledge." Initially funded by a land-grant universities, federal land grant, the institute adopted a Polytechnic, polytechnic model that stressed laboratory instruction in applied science and engineering. MIT moved from Boston to Cambridge in 1916 and grew rapidly through collaboration with private industry, military branches, and new federal basic research agencies, the formation of which was influenced by MIT faculty like Vannevar Bush. In the late twentieth century, MIT became a leading center for research in compu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herman Eisen
Herman Nathaniel Eisen (October 15, 1918 – November 2, 2014) was an American immunologist and cancer researcher. He served on the faculty at New York University School of Medicine in the early 1950s, became the Chief of Dermatology at the Washington University School of Medicine in 1955, and was a founding member of the MIT Center for Cancer Research (now called the Koch Institute for Integrative Cancer Research). Eisen retired and assumed professor emeritus status in 1989, but continued to be active as a researcher; he was working on a manuscript the day he died in 2014. Early life and education Eisen was born in Brooklyn, New York, in 1918, one of four children of Jewish immigrants from Eastern Europe. His undergraduate studies at New York University began in 1934 but were interrupted by a case of tuberculosis, which required him to withdraw from school for a year; he later recalled this as a key event in his life inspiring him to focus on intellectual activities. After grad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T Cell
T cells (also known as T lymphocytes) are an important part of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface receptor, cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature). T cells derive their name from the thymus. After migration to the thymus, the precursor cells mature into several distinct types of T cells. T cell differentiation also continues after they have left the thymus. Groups of specific, differentiated T cell subtypes have a variety of important functions in controlling and shaping the immune response. One of these functions is immune-mediated cell death, and it is carried out by two major subtypes: Cytotoxic T cell, CD8+ "killer" (cytotoxic) and T helper cell, CD4+ "helper" T cells. (These are named for the presen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Degradation
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Protein degradation is a major regulatory mechanism of gene expression and contributes substantially to shaping mammalian proteomes. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes including apoptosis, as well as preventing the accumulation of unwanted or misfolded proteins in cells. Consequently, abnormality in the regulation of proteolysis can cause diseases. Proteolysis can also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taiwan Railways Administration
Taiwan Railways Administration (TRA) was a governmental agency in Taiwan which operated Taiwan Railway from 1948 to 2023. It managed, maintained, and operated conventional passenger and freight Rail transport, railway services on of track. Passenger traffic in 2018 was 231,267,955. On 1 January 2024, Taiwan Railway Administration became a state-owned corporation, Taiwan Railway Corporation. The agency's headquarters was at Taipei Main Station in Zhongzheng District, Taipei at the time of dissolution, the site which became the headquarter of the new company. History The railway between Keelung and Hsinchu was completed during the Taiwan under Qing rule, Qing era in 1893. In 1895, the Qing dynasty, Qing Empire ceded Formosa (Taiwan) to the Empire of Japan after the First Sino-Japanese War. The line was about in length but in a poor condition when the Japanese arrived. The railway was rebuilt and expanded under the of the Government-General of Taiwan during Taiwan under Jap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guangdong Province
) means "wide" or "vast", and has been associated with the region since the creation of Guang Prefecture in AD 226. The name "''Guang''" ultimately came from Guangxin ( zh, labels=no, first=t, t= , s=广信), an outpost established in Han dynasty near modern Wuzhou, whose name is a reference to an order by Emperor Wu of Han to "widely bestow favors and sow trust". Together, Guangdong and Guangxi are called '' Loeng gwong'' ( zh, labels=no, first=t, t=兩廣, s=两广 , p=liǎng guǎng) During the Song dynasty, the Two Guangs were formally separated as ''Guǎngnán Dōnglù'' ( zh, first=t, t=廣南東路, s=广南东路, l=East Circuit in Southern Guang , labels=no) and ''Guǎngnán Xīlù'' ( zh, first=t, t=廣南西路, s=广南西路, l=West Circuit in Southern Guang , labels=no), which became abbreviated as ''Guǎngdōng Lù'' ( zh, first=t, t=廣東路, s=广东路 , labels=no) and ''Guǎngxī Lù'' ( zh, first=t, t=廣西路, s=广西路 , labels=no). "''Dōng''" ( zh, fi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meixian District
Meixian District () is a district of Meizhou City, in northeastern Guangdong Province, China. The district is an important Hakka settlement and is the ancestral home of many Hakka descendants living in Taiwan and other countries worldwide. History Its original name was Chengxiang county () during the southern Han Dynasty where it was first created, all the way to the Song, Yuan and Ming dynasties, and then renamed Jiaying county during the Qing dynasty. It only obtained the name Meixian in 1911 during the Xinhai Revolution. Geography Meixian almost completely surrounds Meizhou's central urban Meijiang District. This is due to the old urban core of Meixian becoming separated from the bulk of the county in the territorial reorganization following the 1949 establishment of the People's Republic of China China, officially the People's Republic of China (PRC), is a country in East Asia. With population of China, a population exceeding 1.4 billion, it is the li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Executive Yuan
The Executive Yuan () is the executive (government), executive branch of the government of the Republic of China (Taiwan). Under the Additional Articles of the Constitution of the Republic of China, amended constitution, the head of the Executive Yuan is the Premier of the Republic of China, Premier who is positioned as the head of government and has the power to appoint members to serve in the cabinet, while the president of the Republic of China, ROC President is the head of state under the semi-presidential system, who can appoint the Premier and nominate the members of the cabinet. The Premier may be removed by a vote of no-confidence by a majority of the Legislative Yuan, after which the President may either remove the Premier or dissolve the Legislative Yuan and initiate a new election for legislators. Organization and structure The Executive Yuan is headed by the Premier of the Republic of China, Premier (or President of the Executive Yuan) and includes its Vice Premi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
