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Tomotherapy
Tomotherapy is a type of radiation therapy treatment machine. In tomotherapy a thin radiation beam is modulated as it rotates around the patient, while they are moved through the bore of the machine. The name comes from the use of a strip-shaped beam, so that only one “slice” (Greek prefix “tomo-”) of the target is exposed at any one time by the radiation. The external appearance of the system and movement of the radiation source and patient can be considered analogous to a CT scanner (computed tomography), which uses lower doses of radiation for imaging. Like a conventional machine used for X-ray external beam radiotherapy (often referred to as a linear accelerator or linac, their main component), it he tomotherapy machinegenerates the radiation beam, but the external appearance of the machine, patient positioning, and treatment delivery differ. Conventional linacs do not work on a slice-by-slice basis but typically have a large area beam which can also be resized and m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas Rockwell Mackie
Thomas “Rock” Mackie is a medical physicist. He grew up in Saskatoon and received his undergraduate degree in Physics from the University of Saskatchewan in 1980. He went on to earn his doctorate in Physics at the University of Alberta in 1984. His expertise is in radiation therapy treatment planning and intensity modulated radiation therapy. He is a primary inventor and algorithm designer of the helical tomotherapy concept. Mackie is a professor in the departments of Medical Physics, Human Oncology, Biomedical Engineering and Engineering Physics at the University of Wisconsin–Madison. He has over 150 peer-reviewed publications, over 15 patents, and has been the supervisor for dozens of Ph.D. students. Mackie is a Fellow of the American Association of Physicists in Medicine and a member at large of that organization’s Science Council. He is also the Vice-Chair of the University of Wisconsin–Madison Calibration Laboratory. Mackie serves as President of the John R. Cameron M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiation Therapy
Radiation therapy or radiotherapy (RT, RTx, or XRT) is a therapy, treatment using ionizing radiation, generally provided as part of treatment of cancer, cancer therapy to either kill or control the growth of malignancy, malignant cell (biology), cells. It is normally delivered by a linear particle accelerator. Radiation therapy may be cure, curative in a number of types of cancer if they are localized to one area of the body, and have not metastasis, spread to other parts. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the canc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
External Beam Radiotherapy
External beam radiation therapy (EBRT) is a form of radiotherapy that utilizes a high-energy collimated beam of ionizing radiation, from a source outside the body, to target and kill cancer cells. The radiotherapy beam is composed of particles, which are focussed in a particular direction of travel using collimators. Each radiotherapy beam consists of one type of particle intended for use in treatment, though most beams contain some contamination by other particle types. Radiotherapy beams are classified by the particle they are intended to deliver, such as photons (as x-rays or gamma rays), electrons, and heavy ions; x-rays and electron beams are by far the most widely used sources for external beam radiotherapy. Orthovoltage ("superficial") X-rays are used for treating skin cancer and superficial structures. Megavoltage X-rays are used to treat deep-seated tumors (e.g. bladder, bowel, prostate, lung, or brain), whereas megavoltage electron beams are typically used to tre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiation Therapy
Radiation therapy or radiotherapy (RT, RTx, or XRT) is a therapy, treatment using ionizing radiation, generally provided as part of treatment of cancer, cancer therapy to either kill or control the growth of malignancy, malignant cell (biology), cells. It is normally delivered by a linear particle accelerator. Radiation therapy may be cure, curative in a number of types of cancer if they are localized to one area of the body, and have not metastasis, spread to other parts. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the canc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stereotactic
Stereotactic surgery is a minimally invasive form of surgery, surgical intervention that makes use of a three-dimensional coordinates, coordinate system to locate small targets inside the body and to perform on them some action such as ablation, biopsy, lesion, injection, Deep brain stimulation, stimulation, implantation, radiosurgery (SRS), etc. In theory, any organ system inside the body can be subjected to stereotactic surgery. However, difficulties in setting up a reliable frame of reference (such as bone landmarks, which bear a constant spatial relation to soft tissues) mean that its applications have been, traditionally and until recently, limited to neurosurgery, brain surgery. Besides the brain, biopsy and surgery of the breast are done routinely to locate, sample (biopsy), and remove tissue. Plain X-ray images (radiography, radiographic mammography), computed tomography, and magnetic resonance imaging can be used to Image-guided surgery, guide the procedure. Another acc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Contralateral
Standard anatomical terms of location are used to describe unambiguously the anatomy of humans and other animals. The terms, typically derived from Latin or Greek roots, describe something in its standard anatomical position. This position provides a definition of what is at the front ("anterior"), behind ("posterior") and so on. As part of defining and describing terms, the body is described through the use of anatomical planes and axes. The meaning of terms that are used can change depending on whether a vertebrate is a biped or a quadruped, due to the difference in the neuraxis, or if an invertebrate is a non-bilaterian. A non-bilaterian has no anterior or posterior surface for example but can still have a descriptor used such as proximal or distal in relation to a body part that is nearest to, or furthest from its middle. International organisations have determined vocabularies that are often used as standards for subdisciplines of anatomy. For example, '' Terminolog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiosurgery
Radiosurgery is surgery using radiation, that is, the destruction of precisely selected areas of tissue using ionizing radiation rather than excision with a blade. Like other forms of radiation therapy (also called radiotherapy), it is usually used to treat cancer. Radiosurgery was originally defined by the Swedish neurosurgeon Lars Leksell as "a single high dose fraction of radiation, stereotactically directed to an intracranial region of interest". In stereotactic radiosurgery (SRS), the word "stereotactic" refers to a three-dimensional coordinate system that enables accurate correlation of a virtual target seen in the patient's diagnostic images with the actual target position in the patient. Stereotactic radiosurgery may also be called stereotactic body radiation therapy (SBRT) or stereotactic ablative radiotherapy (SABR) when used outside the central nervous system (CNS). History Stereotactic radiosurgery was first developed in 1949 by the Swedish neurosurgeon Lars Leksell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Wisconsin–Madison
The University of Wisconsin–Madison (University of Wisconsin, Wisconsin, UW, UW–Madison, or simply Madison) is a public land-grant research university in Madison, Wisconsin, United States. It was founded in 1848 when Wisconsin achieved statehood and is the flagship campus of the University of Wisconsin System. The main campus is located on the shores of Lake Mendota; the university also owns and operates a arboretum south of the main campus. UW–Madison is organized into 13 schools and colleges, which enrolled approximately 34,200 undergraduate and 14,300 graduate and professional students in 2024. Its academic programs include 136 undergraduate majors, 148 master's degree programs, and 120 doctoral programs. Wisconsin is one of the founding members of the Association of American Universities. It is considered a Public Ivy and is classified as an R1 University. UW–Madison was also the home of both the prominent "Wisconsin School" of economics and diplomatic h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Therapeutic Ratio
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose. It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. The related terms therapeutic window or safety window refer to a range of doses optimized between efficacy and toxicity, achieving the greatest therapeutic benefit without resulting in unacceptable side-effects or toxicity. Classically, for clinical indications of an approved drug, TI refers to the ratio of the dose of the drug that causes adverse effects at an incidence/severity not compatible with the targeted indication (e.g. toxic dose in 50% of subjects, TD) to the dose that leads to the desired pharmacological effect (e.g. efficacious dose in 50% of subjects, ED). In contrast, in a drug development setting TI is calculated based on plasma exposure levels. In the early days of pharmaceut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tangential
In geometry, the tangent line (or simply tangent) to a plane curve at a given point is, intuitively, the straight line that "just touches" the curve at that point. Leibniz defined it as the line through a pair of infinitely close points on the curve. More precisely, a straight line is tangent to the curve at a point if the line passes through the point on the curve and has slope , where ''f'' is the derivative of ''f''. A similar definition applies to space curves and curves in ''n''-dimensional Euclidean space. The point where the tangent line and the curve meet or intersect is called the ''point of tangency''. The tangent line is said to be "going in the same direction" as the curve, and is thus the best straight-line approximation to the curve at that point. The tangent line to a point on a differentiable curve can also be thought of as a '' tangent line approximation'', the graph of the affine function that best approximates the original function at the given point. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Splay
Splay may refer to: *Splay, a verb meaning slant, slope or spread outwards *Splay (physiology), the difference between urine threshold and saturation *Splay (Japanese band), a J-pop band from Osaka *Splay Networks, a Sweden-headquartered group of multi-channel networks for Sweden, Finland, Norway, Denmark, and Germany * In architecture **splayed opening, an opening in the wall that broadens on one side **chamfer, a beveled edge connecting two surfaces **talus (fortification), a sloping face at the base of a fortified wall * Splay (plastics), off-colored streaking that occurs in injection molded plastics *Splay tree, a type of search tree *Splay fault Splay may refer to: *Splay, a verb meaning slant, slope or spread outwards * Splay (physiology), the difference between urine threshold and saturation * Splay (Japanese band), a J-pop band from Osaka * Splay Networks, a Sweden-headquartered grou ..., geology * Splay leg, a condition in birds and poultry * ''Splay'' (Shiner album), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
