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Tolerance
Tolerance or toleration is the state of tolerating, or putting up with, conditionally. Economics, business, and politics * Toleration Party, a historic political party active in Connecticut * Tolerant Systems, the former name of Veritas Software * Tolerance tax, a historic tax that was levied against Jews in Hungary Life sciences * Desiccation tolerance, the ability of an organism to endure extreme dryness * Drug tolerance or physiological tolerance, a decrease in the response to a substance due to previous exposure ** Alcohol tolerance ** Multidrug tolerance or antibiotic tolerance, the ability of a disease-causing microorganism to resist killing by antimicrobials * Immune tolerance or immunological tolerance, by which the immune system does not attack an antigen ** Central tolerance, a mechanism by which newly developing T cells and B cells are rendered non-reactive to self ** Immune tolerance in pregnancy or gestational/maternal immune tolerance * Low frustration tolerance, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Tolerance
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that would otherwise have the capacity to elicit an immune response in a given organism. It is induced by prior exposure to that specific antigen and contrasts with conventional immune-mediated elimination of foreign antigens (see Immune response). Tolerance is classified into central tolerance or peripheral tolerance depending on where the state is originally induced—in the thymus and bone marrow (central) or in other tissues and lymph nodes (peripheral). The mechanisms by which these forms of tolerance are established are distinct, but the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Engineering Tolerance
Engineering tolerance is the permissible limit or limits of variation in: # a physical dimension; # a measured value or physical property of a material, manufactured object, system, or service; # other measured values (such as temperature, humidity, etc.); # in engineering and safety, a physical distance or space (tolerance), as in a truck (lorry), train or boat under a bridge as well as a train in a tunnel (see structure gauge and loading gauge); # in mechanical engineering, the space between a bolt and a nut or a hole, etc. Dimensions, properties, or conditions may have some variation without significantly affecting functioning of systems, machines, structures, etc. A variation beyond the tolerance (for example, a temperature that is too hot or too cold) is said to be noncompliant, rejected, or exceeding the tolerance. Considerations when setting tolerances A primary concern is to determine how wide the tolerances may be without affecting other factors or the outcom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tolerance Relation
In universal algebra and lattice theory, a tolerance relation on an algebraic structure is a reflexive symmetric relation that is compatible with all operations of the structure. Thus a tolerance is like a congruence, except that the assumption of transitivity is dropped. On a set, an algebraic structure with empty family of operations, tolerance relations are simply reflexive symmetric relations. A set that possesses a tolerance relation can be described as a tolerance space. Tolerance relations provide a convenient general tool for studying indiscernibility/indistinguishability phenomena. The importance of those for mathematics had been first recognized by Poincaré. Definitions A tolerance relation on an algebraic structure (A,F) is usually defined to be a reflexive symmetric relation on A that is compatible with every operation in F. A tolerance relation can also be seen as a cover of A that satisfies certain conditions. The two definitions are equivalent, since for a f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Tolerance
Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects. Drug tolerance is indicative of drug use but is not necessarily associated with drug dependence or addiction. The process of tolerance development is reversible (e.g., through a drug holiday) and can involve both physiological factors and psychological factors. One may also develop drug tolerance to side effects, in which case tolerance is a desirable characteristic. A medical intervention that has an objective to increase tolerance (e.g., allergen immunotherapy, in which one is exposed to larger and larger amounts of allergen to decrease one's allergic reactions) is called drug desensitization. The opposite concept to drug tolerance is drug reverse tolerance (or drug sensitization), in which cas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tolerance Interval
A tolerance interval is a statistical interval within which, with some confidence level, a specified proportion of a sampled population falls. "More specifically, a 100×p%/100×(1−α) tolerance interval provides limits within which at least a certain proportion (p) of the population falls with a given level of confidence (1−α)." "A (p, 1−α) tolerance interval (TI) based on a sample is constructed so that it would include at least a proportion p of the sampled population with confidence 1−α; such a TI is usually referred to as p-content − (1−α) coverage TI."Krishnamoorthy, K. and Lian, Xiaodong(2011) 'Closed-form approximate tolerance intervals for some general linear models and comparison studies', Journal of Statistical Computation and Simulation, First published on: 13 June 2011 "A (p, 1−α) upper tolerance limit (TL) is simply a 1−α upper confidence limit for the 100 p percentile of the population." A tolerance interval can be seen as a statistical versio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Tolerance
In immunology, central tolerance (also known as negative selection) is the process of eliminating any ''developing'' T or B lymphocytes that are autoreactive, i.e. reactive to the body itself. Through elimination of autoreactive lymphocytes, tolerance ensures that the immune system does not attack self peptides. Lymphocyte maturation (and central tolerance) occurs in primary lymphoid organs such as the bone marrow and the thymus. In mammals, B cells mature in the bone marrow and T cells mature in the thymus. Central tolerance is not perfect, so peripheral tolerance exists as a secondary mechanism to ensure that T and B cells are not self-reactive once they leave primary lymphoid organs. Peripheral tolerance is distinct from central tolerance in that it occurs once developing immune cells exit primary lymphoid organs (the thymus and bone-marrow), prior to their export into the periphery. Function of central tolerance Central tolerance is essential to proper immune cell func ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tolerance Analysis
Tolerance analysis is the general term for activities related to the study of accumulated variation in mechanical parts and assemblies. Its methods may be used on other types of systems subject to accumulated variation, such as mechanical and electrical systems. Engineers analyze tolerances for the purpose of evaluating geometric dimensioning and tolerancing (GD&T). Methods include 2D tolerance stacks, 3D Monte Carlo simulations, and datum conversions. Tolerance stackups or tolerance stacks are used to describe the problem-solving process in mechanical engineering of calculating the effects of the accumulated variation that is allowed by specified dimensions and tolerances. Typically these dimensions and tolerances are specified on an engineering drawing. Arithmetic tolerance stackups use the worst-case maximum or minimum values of dimensions and tolerances to calculate the maximum and minimum distance (clearance or interference) between two features or parts. Statistical toler ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paradox Of Tolerance
The paradox of tolerance states that if a society is tolerant without limit, its ability to be tolerant is eventually seized or destroyed by the intolerant. Karl Popper described it as the seemingly self-contradictory idea that in order to maintain a tolerant society, the society must retain the right to be intolerant of intolerance. Discussions In 1945, philosopher Karl Popper attributed the paradox to Plato's defense of " benevolent despotism" and defined it in ''The Open Society and Its Enemies''. The term "paradox of tolerance" does not appear anywhere in the main text of ''The Open Society and Its Enemies''. Rather, Popper lists the above as a note to chapter 7, among the mentioned paradoxes proposed by Plato in his apologia for "benevolent despotism"—i.e., true tolerance would inevitably lead to intolerance, so autocratic rule of an enlightened "philosopher-king" would be preferable to leaving the question of tolerance up to majority rule. In the context of chapter 7 o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toleration
Toleration is the allowing, permitting, or acceptance of an action, idea, object, or person which one dislikes or disagrees with. Political scientist Andrew R. Murphy explains that "We can improve our understanding by defining "toleration" as a set of social or political practices and "tolerance" as a set of attitudes." '' Random House Dictionary'' defines tolerance as "a fair, objective, and permissive attitude toward those whose opinions, beliefs, practices, racial or ethnic origins, etc., differ from one's own". Both these concepts inherently contain the idea of alterity, the state of ''otherness.'' Additional choices of how to respond to the "other," beyond toleration, do exist. Therefore, in some instances, toleration has been seen as ‘a flawed virtue’ because it concerns acceptance of things that were better overcome. Toleration cannot, therefore, be defined as a universal good, and many of its applications and uses remain contested. Religious toleration may signify ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pain Tolerance
Pain tolerance is the maximum level of pain that a person is able to tolerate. Pain tolerance is distinct from pain threshold (the point at which pain begins to be felt)."IASP Taxonomy, Pain Terms". Retrieved 4 December 2014 The of pain that goes in to pain tolerance has two major components. First is the biological component—the headache or skin prickling that activates pain receptors. Second is the brain’s perception of pain—how much focus is spent paying attention to or ignoring the pain. The brain’s perception of pain is a response to signals from pain receptors that sensed the pain in the first place. Factors Sex |
Alcohol Tolerance
Alcohol tolerance refers to the bodily responses to the functional effects of ethanol in alcoholic beverages. This includes direct tolerance, speed of recovery from insobriety and resistance to the development of alcohol use disorder. Consumption-induced tolerance Alcohol tolerance is increased by regular drinking. This reduced sensitivity to the physical effects of alcohol consumption requires that higher quantities of alcohol be consumed in order to achieve the same effects as before tolerance was established. Alcohol tolerance may lead to (or be a sign of) alcohol dependence. Heavy alcohol consumption over a period of years can lead to "reverse tolerance". A liver can be damaged by chronic alcohol use, leading to a buildup of fat and scar tissue. The reduced ability of such a liver to metabolize or break down alcohol means that small amounts can lead to a high blood alcohol concentration (BAC) and more rapid intoxication. Physiology of alcohol tolerance Direct alcohol toler ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Low Frustration Tolerance
Low frustration tolerance (LFT), or "short-term hedonism," is a concept utilized to describe the inability to tolerate unpleasant feelings or stressful situations. It stems from the feeling that reality should be as wished, and that any frustration should be resolved quickly and easily. People with low frustration tolerance experience emotional disturbance when frustrations are not quickly resolved. Behaviors are then directed towards avoiding frustrating events which, paradoxically, leads to increased frustration and even greater mental stress. In REBT, the opposite construct is " high frustration tolerance". History The concept was originally developed by psychologist Albert Ellis who theorized that low frustration tolerance is an evaluative component in dysfunctional and irrational beliefs. His theory of REBT proposes that irrational beliefs and the avoidance of stressful situations is the origin of behavioral and emotional problems. As humans, we tend to seek for instant gr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
