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Timeline Of Peptic Ulcer Disease And Helicobacter Pylori
This is a timeline of the events relating to the discovery that peptic ulcer disease and some cancers are caused by ''H. pylori''. In 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Physiology or Medicine for their discovery that peptic ulcer disease (PUD) was primarily caused by ''Helicobacter pylori'', a bacterium with affinity for acidic environments, such as the stomach. As a result, PUD that is associated with ''H. pylori'' is currently treated with antibiotics used to eradicate the infection. For decades prior to their discovery, it was widely believed that PUD was caused by excess acid in the stomach. During this time, acid control was the primary method of treatment for PUD, to only partial success. Among other effects, it is now known that acid suppression alters the stomach milieu to make it less amenable to ''H. pylori'' infection. Background Before the 1950s, there were many microbiological descriptions of bacteria in the stomach and in ga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carcinogen
A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis (the formation of cancer). This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. Common examples of non-radioactive carcinogens are inhaled asbestos, certain dioxins, and tobacco smoke. Although the public generally associates carcinogenicity with synthetic chemicals, it is equally likely to arise from both natural and synthetic substances. Carcinogens are not necessarily immediately toxic; thus, their effect can be insidious. Carcinogens, as mentioned, are agents in the environment capable of contributing to cancer growth. Carcinogens can be categorized into two different types: activation-dependent and activation-independent, and each nature impacts their ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Beaumont
William Beaumont (November 21, 1785 – April 25, 1853) was a surgeon in the U.S. Army who became known as the "Father of Gastric Physiology" following his research on human digestion.William Beaumont Papers (1812-1959) ''National Library of Medicine'' Biography Early life 
William Beaumont was born to Samuel Beaumont and Lucretia Abel in
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Gastric Cancer
Stomach cancer, also known as gastric cancer, is a cancer that develops from the lining of the stomach. Most cases of stomach cancers are gastric carcinomas, which can be divided into a number of subtypes, including gastric adenocarcinomas. Lymphomas and mesenchymal tumors may also develop in the stomach. Early symptoms may include heartburn, upper abdominal pain, nausea, and loss of appetite. Later signs and symptoms may include weight loss, yellowing of the skin and whites of the eyes, vomiting, difficulty swallowing, and blood in the stool, among others. The cancer may spread from the stomach to other parts of the body, particularly the liver, lungs, bones, lining of the abdomen, and lymph nodes. The most common cause is infection by the bacterium ''Helicobacter pylori'', which accounts for more than 60% of cases. Certain types of ''H. pylori'' have greater risks than others. Smoking, dietary factors such as pickled vegetables and obesity are other risk factors. Abou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gastritis
Gastritis is inflammation of the lining of the stomach. It may occur as a short episode or may be of a long duration. There may be no symptoms but, when symptoms are present, the most common is upper abdominal pain (see dyspepsia). Other possible symptoms include nausea and vomiting, bloating, loss of appetite and heartburn. Complications may include stomach bleeding, stomach ulcers, and stomach tumors. When due to autoimmune problems, low red blood cells due to not enough vitamin B12 may occur, a condition known as pernicious anemia. Common causes include infection with ''Helicobacter pylori'' and use of nonsteroidal anti-inflammatory drugs ( NSAIDs). Less common causes include alcohol, smoking, cocaine, severe illness, autoimmune problems, radiation therapy and Crohn's disease. Endoscopy, a type of X-ray known as an upper gastrointestinal series, blood tests, and stool tests may help with diagnosis. The symptoms of gastritis may be a presentation of a myocardial infa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
François-Joseph-Victor Broussais
François-Joseph-Victor Broussais (17 December 1772 – 17 November 1838) was a French physician. Life François-Joseph-Victor Broussais was born in Saint-Malo. From his father, who was also a physician, he received his first instructions in medicine, and he studied for some years at a college in Dinan named after him, "Collège François Broussais". At the age of seventeen he entered one of the newly formed republican regiments, but ill-health compelled him to withdraw after two years. He resumed his medical studies, and then obtained an appointment as surgeon in the navy. In 1799 he proceeded to Paris, where he studied under physician, surgeon, and physiologist Xavier Bichat. Bichat's focus on the strong connection between physiology pathology can also be recognized in Broussais' medical theories. In 1803 he graduated as M.D. and in 1805 he again joined the army in a professional capacity, and served in Germany and the Netherlands. He returned to Paris, then left again for active ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matthew Baillie
Matthew Baillie FRS (27 October 1761 – 23 September 1823) was a British physician and pathologist, credited with first identifying transposition of the great vessels (TGV) and situs inversus. Early life and education He was born in the manse at Shotts in Lanarkshire, the son of Rev Prof James Baillie DD (1723-1778) and his wife, Dorothea Hunter (sister of Dr John Hunter and Dr William Hunter. His father was Professor of Divinity at Glasgow University. His sisters were centenarian Agnes Baillie (1760-1761) and poet/author Joanna Baillie. He was a pupil of his uncle, the anatomist John Hunter and his father-in-law, Dr. Thomas Denman, a pre-eminent obstetrician in London at the turn of the nineteenth century, whose textbook on childbirth had been first published in 1788. Baillie was educated at the Old Grammar School of Hamilton (renamed the Hamilton Academy in 1848), the University of Glasgow, and obtained his MD from the University of Oxford in 1789, having been named Snel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fever
Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using values between in humans. The increase in set point triggers increased muscle contractions and causes a feeling of cold or chills. This results in greater heat production and efforts to conserve heat. When the set point temperature returns to normal, a person feels hot, becomes flushed, and may begin to sweat. Rarely a fever may trigger a febrile seizure, with this being more common in young children. Fevers do not typically go higher than . A fever can be caused by many medical conditions ranging from non-serious to life-threatening. This includes viral, bacterial, and parasitic infections—such as influenza, the common cold, meningitis, urinary tract infections, appendicitis, Lassa, COVID-19, and malaria. Non-infectious cause ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Duodenal Ulcer
Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus. An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines is a duodenal ulcer. The most common symptoms of a duodenal ulcer are waking at night with upper abdominal pain and upper abdominal pain that improves with eating. With a gastric ulcer, the pain may worsen with eating. The pain is often described as a burning or dull ache. Other symptoms include belching, vomiting, weight loss, or poor appetite. About a third of older people have no symptoms. Complications may include bleeding, perforation, and blockage of the stomach. Bleeding occurs in as many as 15% of cases. Common causes include the bacteria ''Helicobacter pylori'' and non-steroidal anti-inflammatory drugs (NSAIDs). Other, less common causes include tobacco smoking, stress as a result of other serious health conditions, Behç ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gastric Ulcer
Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus. An ulcer in the stomach is called a gastric ulcer, while one in the first part of the intestines is a duodenal ulcer. The most common symptoms of a duodenal ulcer are waking at night with upper abdominal pain and upper abdominal pain that improves with eating. With a gastric ulcer, the pain may worsen with eating. The pain is often described as a burning or dull ache. Other symptoms include belching, vomiting, weight loss, or poor appetite. About a third of older people have no symptoms. Complications may include bleeding, perforation, and blockage of the stomach. Bleeding occurs in as many as 15% of cases. Common causes include the bacteria ''Helicobacter pylori'' and non-steroidal anti-inflammatory drugs (NSAIDs). Other, less common causes include tobacco smoking, stress as a result of other serious health conditions, Behçet's dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Avicenna
Ibn Sina ( fa, ابن سینا; 980 – June 1037 CE), commonly known in the West as Avicenna (), was a Persian polymath who is regarded as one of the most significant physicians, astronomers, philosophers, and writers of the Islamic Golden Age, and the father of early modern medicine. Sajjad H. Rizvi has called Avicenna "arguably the most influential philosopher of the pre-modern era". He was a Muslim Peripatetic philosopher influenced by Greek Aristotelian philosophy. Of the 450 works he is believed to have written, around 240 have survived, including 150 on philosophy and 40 on medicine. His most famous works are '' The Book of Healing'', a philosophical and scientific encyclopedia, and '' The Canon of Medicine'', a medical encyclopedia which became a standard medical text at many medieval universities and remained in use as late as 1650. Besides philosophy and medicine, Avicenna's corpus includes writings on astronomy, alchemy, geography and geology, psyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gastric
The stomach is a muscular, hollow organ in the gastrointestinal tract of humans and many other animals, including several invertebrates. The stomach has a dilated structure and functions as a vital organ in the digestive system. The stomach is involved in the gastric phase of digestion, following chewing. It performs a chemical breakdown by means of enzymes and hydrochloric acid. In humans and many other animals, the stomach is located between the oesophagus and the small intestine. The stomach secretes digestive enzymes and gastric acid to aid in food digestion. The pyloric sphincter controls the passage of partially digested food ( chyme) from the stomach into the duodenum, where peristalsis takes over to move this through the rest of intestines. Structure In the human digestive system, the stomach lies between the oesophagus and the duodenum (the first part of the small intestine). It is in the left upper quadrant of the abdominal cavity. The top of the stomach lies ag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
