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Thomas C. Südhof
Thomas Christian Südhof (; born December 22, 1955), ForMemRS, is a German-American biochemist known for his study of synaptic transmission. Currently, he is a professor in the school of medicine in the department of molecular and cellular physiology, and by courtesy in neurology, and in psychiatry and behavioral sciences at Stanford University. Südhof, James Rothman and Randy Schekman are the 2013 Nobel Prize in Physiology or Medicine laureates for their work on vesicle trafficking. Südhof retracteLin et al. 2023research paper published in PNAS from his lab due to falsified data, and since mid-2022, PubPeer commenters including Elisabeth Bik have flagged 46 of Südhof’s papers, which explore how neurons communicate across synapses. Early life and education A German native, Südhof was born in Göttingen in 1955. He spent his childhood in Göttingen and Hannover. He studied music in his youth, specifically the bassoon, and has credited his bassoon instructor, Herber ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Göttingen
Göttingen (, ; ; ) is a college town, university city in Lower Saxony, central Germany, the Capital (political), capital of Göttingen (district), the eponymous district. The River Leine runs through it. According to the 2022 German census, the population of Göttingen was 124,548. Overview The origins of Göttingen lay in a village called ''Gutingi, ''first mentioned in a document in 953 AD. The city was founded northwest of this village, between 1150 and 1200 AD, and adopted its name. In Middle Ages, medieval times the city was a member of the Hanseatic League and hence a wealthy town. Today, Göttingen is famous for its old university (''Georgia Augusta'', or University of Göttingen, "Georg-August-Universität"), which was founded in 1734 (first classes in 1737) and became the most visited university of Europe. In 1837, seven professors protested against the absolute sovereignty of the House of Hanover, kings of Kingdom of Hanover, Hanover; they lost their positions, but ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionist, reductionism) to biological research. This multifaceted research domain necessitates the collaborative efforts of chemists, biologists, mathematicians, physicists, and engineers to decipher the biology of intricate living systems by merging various quantitative molecular measurements with carefully constructed mathematical models. It represents a comprehensive method for comprehending the complex relationships within biological systems. In contrast to conventional biological studies that typically center on isolated elements, systems biology seeks to combine different biological data to create models that illustrate and elucidate the dynamic interactions with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Medicine
A Doctor of Medicine (abbreviated MD, from the Latin language, Latin ) is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the ''MD'' denotes a professional degree of physician. This generally arose because many in 18th-century medical professions trained in Scotland, which used the MD degree nomenclature. In England, however, Bachelor of Medicine, Bachelor of Surgery (MBBS) was used: in the 19th century, it became the standard in Scotland too. Thus, in the United Kingdom, Republic of Ireland, Ireland and other countries, the MD is a research doctorate, honorary degree, honorary doctorate or applied clinical degree restricted to those who already hold a professional degree (Bachelor's/Master's/Doctoral) in medicine. In those countries, the equivalent professional degree to the North American, and some others' usage of MD is still typically titled Bachelor of Medicine, Bachelor of Surgery. History The fi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Planck Institute For Biophysical Chemistry
The Max Planck Institute for Biophysical Chemistry (), also known as the Karl-Friedrich Bonhoeffer Institute (), was a research institute of the Max Planck Society, located in Göttingen, Germany. On January 1, 2022, the institute merged with the Max Planck Institute for Experimental Medicine in Göttingen to form the Max Planck Institute for Multidisciplinary Sciences. This was the only Max Planck Institute (MPI) that combined the three classical scientific disciplines – biology, physics and chemistry. Founded in 1971, its initial focus was on problems in physics in chemistry. It had undergone a continuous evolution manifested through an expanding range of core subjects and work areas such as neurobiology, biochemistry, and molecular biology. At the time of merger, 850 people worked at the institute, about half of them scientists. Four researchers working at the institute – Stefan Hell, 2014; Erwin Neher and Bert Sakmann, 1991; and Manfred Eigen, 1967 – were awarded ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromaffin Cells
Chromaffin cells, also called pheochromocytes (or phaeochromocytes), are neuroendocrine cells found mostly in the medulla of the adrenal glands in mammals. These cells serve a variety of functions such as serving as a response to stress, monitoring carbon dioxide and oxygen concentrations in the body, maintenance of respiration and the regulation of blood pressure. They are in close proximity to pre-synaptic sympathetic ganglia of the sympathetic nervous system, with which they communicate, and structurally they are similar to post-synaptic sympathetic neurons. In order to activate chromaffin cells, the splanchnic nerve of the sympathetic nervous system releases acetylcholine, which then binds to nicotinic acetylcholine receptors on the adrenal medulla. This causes the release of catecholamines. The chromaffin cells release catecholamines: ~80% of adrenaline (epinephrine) and ~20% of noradrenaline (norepinephrine) into systemic circulation for systemic effects on multiple org ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University
Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyman John Harvard (clergyman), John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of Colonial history of the United States, colonial-era Massachusetts Bay Colony. While never formally affiliated with any Religious denomination, denomination, Harvard trained Congregationalism in the United States, Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Waldorf Education
Waldorf education, also known as Steiner education, is based on the educational philosophy of Rudolf Steiner, the founder of anthroposophy. Its educational style is holistic, intended to develop pupils' intellectual, artistic, and practical skills, with a focus on imagination and creativity. Individual teachers have a great deal of autonomy in curriculum content, teaching methods, and governance. Qualitative assessments of student work are integrated into the daily life of the classroom, with standardized testing limited to what is required to enter post-secondary education. The first Waldorf school opened in 1919 in Stuttgart, Germany. A century later, it has become the largest independent school movement in the world, with more than 1,200 independent schools and nearly 2,000 kindergartens in 75 countries, as well as more than 500 centers for special education in more than 40 countries. There are also numerous Waldorf-based public schools, charter schools, and academies, as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bassoon
The bassoon is a musical instrument in the woodwind family, which plays in the tenor and bass ranges. It is composed of six pieces, and is usually made of wood. It is known for its distinctive tone color, wide range, versatility, and virtuosity. It is a non-transposing instrument and typically its music is written in the bass and tenor clefs, and sometimes in the treble. There are two forms of modern bassoon: the Buffet (or French) and Heckel (or German) systems. It is typically played while sitting using a seat strap, but can be played while standing if the player has a harness to hold the instrument. Sound is produced by rolling both lips over the reed and blowing direct air pressure to cause the reed to vibrate. Its fingering system can be quite complex when compared to those of other instruments. Appearing in its modern form in the 19th century, the bassoon figures prominently in orchestral, concert band, and chamber music literature, and is occasionally heard in pop, rock, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hannover
Hanover ( ; ; ) is the capital and largest city of the States of Germany, German state of Lower Saxony. Its population of 535,932 (2021) makes it the List of cities in Germany by population, 13th-largest city in Germany as well as the fourth-largest in northern Germany after Berlin, Hamburg and Bremen. Hanover's urban area comprises the towns of Garbsen, Langenhagen and Laatzen and has a population of about 791,000 (2018). The Hanover Region has approximately 1.16 million inhabitants (2019) and is the largest in the Hannover–Braunschweig–Göttingen–Wolfsburg Metropolitan Region, Hanover–Braunschweig–Göttingen–Wolfsburg Metropolitan Region, the List of EU metropolitan areas by GDP, 17th biggest metropolitan area by GDP in the European Union. Before it became the capital of Lower Saxony in 1946, Hanover was the capital of the Principality of Calenberg (1636–1692), the Electorate of Hanover (1692–1814), the Kingdom of Hanover (1814–1866), the Province of Hannove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germans
Germans (, ) are the natives or inhabitants of Germany, or sometimes more broadly any people who are of German descent or native speakers of the German language. The Basic Law for the Federal Republic of Germany, constitution of Germany, implemented in 1949 following the end of World War II, defines a German as a German nationality law, German citizen. During the 19th and much of the 20th century, discussions on German identity were dominated by concepts of a common language, culture, descent, and history.. "German identity developed through a long historical process that led, in the late 19th and early 20th centuries, to the definition of the German nation as both a community of descent (Volksgemeinschaft) and shared culture and experience. Today, the German language is the primary though not exclusive criterion of German identity." Today, the German language is widely seen as the primary, though not exclusive, criterion of German identity. Estimates on the total number of Germ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elisabeth Bik
Elisabeth Margaretha Harbers-Bik (born 1966) is a Dutch microbiologist and scientific integrity consultant. Bik is known for her work detecting photo manipulation in scientific publications, and identifying over 4,000 potential cases of improper research conduct. Bik is the founder of Microbiome Digest, a blog with daily updates on microbiome research, and the Science Integrity Digest blog. Bik was awarded the 2021 John Maddox Prize for "outstanding work exposing widespread threats to research integrity in scientific papers". Early life and education Bik was born in the Netherlands. She studied at the Utrecht University, where she obtained her MSc degree and subsequently a PhD in 1996, both in microbiology. Her dissertation was about developing vaccines for new strains of ''Vibrio cholerae'' involved in cholera epidemics across India and Bangladesh. She conducted her doctorate and her postdoctoral studies at the molecular microbiology department in the National Institute of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vesicle (biology And Chemistry)
In cell biology, a vesicle is a structure within or outside a cell, consisting of liquid or cytoplasm enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion ( exocytosis), uptake (endocytosis), and the transport of materials within the plasma membrane. Alternatively, they may be prepared artificially, in which case they are called liposomes (not to be confused with lysosomes). If there is only one phospholipid bilayer, the vesicles are called ''unilamellar liposomes''; otherwise they are called ''multilamellar liposomes''. The membrane enclosing the vesicle is also a lamellar phase, similar to that of the plasma membrane, and intracellular vesicles can fuse with the plasma membrane to release their contents outside the cell. Vesicles can also fuse with other organelles within the cell. A vesicle released from the cell is known as an extracellular vesicle. Vesicles perform a variety of functions. Because it is separated from the cytosol, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
