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Tetrode (biology)
A tetrode is a type of electrode used in neuroscience for electrophysiological recordings. They are generally used to record the extracellular field potentials from nervous tissue, e.g. the brain. Tetrodes are constructed by bundling together four very small electrodes; each wire is generally less than 30 μm in diameter. Tetrodes are used to classify extra-cellular action potentials into sets generated by the individual neurons, as each channel of the tetrode is usually close enough to a cell such that action potentials emitted by that cell are detected on each of the four channels, but because of the spatial distribution of the individual channels, the amplitude of the signal varies across the four channels. Tetrodes can be built into an implantable device called micro-drive that moves them up and down with precision in the brain of experimental animals Clustering Clustering techniques involve both examining the waveform of individual spikes, and examining the spike heig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience
Neuroscience is the science, scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a Multidisciplinary approach, multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and Mathematical Modeling, mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the Biology, biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular biology, molecular and cell biology, cellular studies of indivi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrophysiology
Electrophysiology (from Greek , ''ēlektron'', "amber" Electron#Etymology">etymology of "electron" , ''physis'', "nature, origin"; and , ''-logia'') is the branch of physiology that studies the electrical properties of biological cells and tissues. It involves measurements of voltage changes or electric current or manipulations on a wide variety of scales from single ion channel proteins to whole organs like the heart. In neuroscience, it includes measurements of the electrical activity of neurons, and, in particular, action potential activity. Recordings of large-scale electric signals from the nervous system, such as electroencephalography, may also be referred to as electrophysiological recordings. They are useful for electrodiagnosis and monitoring. Definition and scope Classical electrophysiological techniques Principle and mechanisms Electrophysiology is the branch of physiology that pertains broadly to the flow of ions ( ion current) in biological tissues and, in pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracellular Field Potential
Local field potentials (LFP) are transient electrical signals generated in nervous and other tissues by the summed and synchronous electrical activity of the individual cells (e.g. neurons) in that tissue. LFP are "extracellular" signals, meaning that they are generated by transient imbalances in ion concentrations in the spaces outside the cells, that result from cellular electrical activity. LFP are 'local' because they are recorded by an electrode placed nearby the generating cells. As a result of the Inverse-square law, such electrodes can only 'see' potentials in spatially limited radius. They are 'potentials' because they are generated by the voltage that results from charge separation in the extracellular space. They are 'field' because those extracellular charge separations essentially create a local electric field. LFP are typically recorded with a high-impedance microelectrode placed in the midst of the population of cells generating it. They can be recorded, for exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head ( cephalization), usually near organs for special senses such as vision, hearing and olfaction. Being the most specialized organ, it is responsible for receiving information from the sensory nervous system, processing those information (thought, cognition, and intelligence) and the coordination of motor control (muscle activity and endocrine system). While invertebrate brains arise from paired segmental ganglia (each of which is only responsible for the respective body segment) of the ventral nerve cord, vertebrate brains develop axially from the midline dorsal nerve cord as a vesicular enlargement at the rostral end of the neural tube, with centralized control over all body segments. All vertebrate brains can be embryonically divided into three parts: the forebrain (prosencep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Action Potential
An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and in some plant cells. Certain endocrine cells such as pancreatic beta cells, and certain cells of the anterior pituitary gland are also excitable cells. In neurons, action potentials play a central role in cell-cell communication by providing for—or with regard to saltatory conduction, assisting—the propagation of signals along the neuron's axon toward synaptic boutons situated at the ends of an axon; these signals can then connect with other neurons at synapses, or to motor cells or glands. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of event ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrode
A tetrode is a vacuum tube (called ''valve'' in British English) having four active electrodes. The four electrodes in order from the centre are: a thermionic cathode, first and second grids and a plate (called ''anode'' in British English). There are several varieties of tetrodes, the most common being the screen-grid tube and the beam tetrode. In screen-grid tubes and beam tetrodes, the first grid is the control grid and the second grid is the screen grid. In other tetrodes one of the grids is a control grid, while the other may have a variety of functions. The tetrode was developed in the 1920s by adding an additional grid to the first amplifying vacuum tube, the triode, to correct limitations of the triode. During the period 1913 to 1927, three distinct types of tetrode valves appeared. All had a normal control grid whose function was to act as a primary control for current passing through the tube, but they differed according to the intended function of the other gri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrode Transistor
A tetrode transistor is any transistor having four active terminals. Early tetrode transistors There were two types of tetrode transistor developed in the early 1950s as an improvement over the point-contact transistor and the later grown-junction transistor and alloy-junction transistor. Both offered much higher speed than earlier transistors. *Point-contact transistor having two emitters. It became obsolete in the middle 1950s. *Modified grown-junction transistor or alloy-junction transistor having two connections at opposite ends of the base. It achieved its high speed by reducing the input to output capacitance. It became obsolete in the early 1960s with the development of the diffusion transistor. Modern tetrode transistors *Dual emitter transistor, used in two-input transistor-transistor logic gates *Dual collector transistor, used in two-output integrated injection logic gates * Diffused planar silicon bipolar junction transistor, - ''Tetrode transistor memory logic cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrophysiology
Electrophysiology (from Greek , ''ēlektron'', "amber" Electron#Etymology">etymology of "electron" , ''physis'', "nature, origin"; and , ''-logia'') is the branch of physiology that studies the electrical properties of biological cells and tissues. It involves measurements of voltage changes or electric current or manipulations on a wide variety of scales from single ion channel proteins to whole organs like the heart. In neuroscience, it includes measurements of the electrical activity of neurons, and, in particular, action potential activity. Recordings of large-scale electric signals from the nervous system, such as electroencephalography, may also be referred to as electrophysiological recordings. They are useful for electrodiagnosis and monitoring. Definition and scope Classical electrophysiological techniques Principle and mechanisms Electrophysiology is the branch of physiology that pertains broadly to the flow of ions ( ion current) in biological tissues and, in pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
