Synthetic Nervous System
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Synthetic Nervous System
Synthetic Nervous System (SNS) is a computational neuroscience model that may be developed with the Functional Subnetwork Approach (FSA) to create biologically plausible models of circuits in a nervous system. The FSA enables the direct analytical tuning of dynamical networks that perform specific operations within the nervous system without the need for global optimization methods like genetic algorithms and reinforcement learning. The primary use case for a SNS is system control, where the system is most often a simulated biomechanical model or a physical robotic platform. An SNS is a form of a neural network much like artificial neural networks (ANNs), convolutional neural networks (CNN), and recurrent neural networks (RNN). The building blocks for each of these neural networks is a series of nodes and connections denoted as neurons and synapses. More conventional artificial neural networks rely on Machine learning, training phases where they use large data sets to form correlat ...
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Computational Neuroscience
Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of  neuroscience which employs mathematics, computer science, theoretical analysis and abstractions of the brain to understand the principles that govern the development, structure, physiology and cognitive abilities of the nervous system. Computational neuroscience employs computational simulations to validate and solve mathematical models, and so can be seen as a sub-field of theoretical neuroscience; however, the two fields are often synonymous. The term mathematical neuroscience is also used sometimes, to stress the quantitative nature of the field. Computational neuroscience focuses on the description of biologically plausible neurons (and neural systems) and their physiology and dynamics, and it is therefore not directly concerned with biologically unrealistic models used in connectionism, control theory, cybernetics, quantitative psychology, machine le ...
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Central Pattern Generator
Central pattern generators (CPGs) are self-organizing biological neural circuits that produce rhythmic outputs in the absence of rhythmic input. They are the source of the tightly-coupled patterns of neural activity that drive rhythmic and stereotyped motor behaviors like walking, swimming, breathing, or chewing. The ability to function without input from higher brain areas still requires modulatory inputs, and their outputs are not fixed. Flexibility in response to sensory input is a fundamental quality of CPG-driven behavior. To be classified as a rhythmic generator, a CPG requires: # "two or more processes that interact such that each process sequentially increases and decreases, and # that, as a result of this interaction, the system repeatedly returns to its starting condition." CPGs are found in humans and most other vertebrates, and in some invertebrates. Physiology CPG neurons CPG neurons can have different intrinsic membrane properties (see schematic). Some neurons ...
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Biological Neuron Model
Biological neuron models, also known as spiking neuron models, are mathematical descriptions of the conduction of electrical signals in neurons. Neurons (or nerve cells) are electrically excitable cells within the nervous system, able to fire electric signals, called action potentials, across a neural network. These mathematical models describe the role of the biophysical and geometrical characteristics of neurons on the conduction of electrical activity. Central to these models is the description of how the membrane potential (that is, the difference in electric potential between the interior and the exterior of a biological cell) across the cell membrane changes over time. In an experimental setting, stimulating neurons with an electrical current generates an action potential (or spike), that propagates down the neuron's axon. This axon can branch out and connect to a large number of downstream neurons at sites called synapses. At these synapses, the spike can cause the re ...
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Pre-Bötzinger Complex
The preBötzinger complex, often abbreviated as preBötC, is a functionally and anatomically specialized site in the ventral-lateral region of the lower medulla oblongata (i.e., lower brainstem). The preBötC is part of the ventral respiratory group of respiratory related interneurons. Its foremost function is to generate the inspiratory breathing rhythm in mammals. In addition, the preBötC is widely and paucisynaptically connected to higher brain centers that regulate arousal and excitability more generally such that respiratory brain function is intimately connected with many other rhythmic and cognitive functions of the brain and central nervous system. Further, the preBötC receives mechanical sensory information from the airways that encode lung volume as well as pH, oxygen, and carbon dioxide content of circulating blood and the cerebrospinal fluid. The preBötC is approximately colocated with the hypoglossal (XII) cranial motor nucleus as well as the ‘loop’ portion of the ...
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Backpropagation
In machine learning, backpropagation is a gradient computation method commonly used for training a neural network to compute its parameter updates. It is an efficient application of the chain rule to neural networks. Backpropagation computes the gradient of a loss function with respect to the weights of the network for a single input–output example, and does so efficiently, computing the gradient one layer at a time, iterating backward from the last layer to avoid redundant calculations of intermediate terms in the chain rule; this can be derived through dynamic programming. Strictly speaking, the term ''backpropagation'' refers only to an algorithm for efficiently computing the gradient, not how the gradient is used; but the term is often used loosely to refer to the entire learning algorithm – including how the gradient is used, such as by stochastic gradient descent, or as an intermediate step in a more complicated optimizer, such as Adaptive Moment Estimation. The ...
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Gradient Descent
Gradient descent is a method for unconstrained mathematical optimization. It is a first-order iterative algorithm for minimizing a differentiable multivariate function. The idea is to take repeated steps in the opposite direction of the gradient (or approximate gradient) of the function at the current point, because this is the direction of steepest descent. Conversely, stepping in the direction of the gradient will lead to a trajectory that maximizes that function; the procedure is then known as ''gradient ascent''. It is particularly useful in machine learning for minimizing the cost or loss function. Gradient descent should not be confused with local search algorithms, although both are iterative methods for optimization. Gradient descent is generally attributed to Augustin-Louis Cauchy, who first suggested it in 1847. Jacques Hadamard independently proposed a similar method in 1907. Its convergence properties for non-linear optimization problems were first studied by Has ...
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Graded Chemical Synapse
Grade most commonly refers to: * Grading in education, a measurement of a student's performance by educational assessment (e.g. A, pass, etc.) * A designation for students, classes and curricula indicating the number of the year a student has reached in a given educational stage (e.g. first grade, second grade, K–12, etc.) * Grade (slope), the steepness of a slope * Graded voting Grade or grading may also refer to: Music * Grade (music), a formally assessed level of profiency in a musical instrument * Grade (band), punk rock band * Grades (producer), British electronic dance music producer and DJ Science and technology Biology and medicine * Grading (tumors), a measure of the aggressiveness of a tumor in medicine * The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach * Evolutionary grade, a paraphyletic group of organisms Geology * Graded bedding, a description of the variation in grain size through a bed in a sedimentary rock * Metamorphic ...
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Neuromodulation
Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors (GPCRs) to initiate a second messenger signaling cascade that induces a broad, long-lasting signal. This modulation can last for hundreds of milliseconds to several minutes. Some of the effects of neuromodulators include altering intrinsic firing activity, increasing or decreasing voltage-dependent currents, altering synaptic efficacy, increasing bursting activity and reconfiguring synaptic connectivity. Major neuromodulators in the central nervous system include: dopamine, serotonin, acetylcholine, histamine, norepinephrine, nitric oxide, and several neuropeptides. Cannabinoids can also be powerful CNS neuromodulators. Neuromodulators can be packaged into vesicles and released by neurons, secreted as hormones and delivered through the circulatory system ...
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Low-pass Filter
A low-pass filter is a filter that passes signals with a frequency lower than a selected cutoff frequency and attenuates signals with frequencies higher than the cutoff frequency. The exact frequency response of the filter depends on the filter design. The filter is sometimes called a high-cut filter, or treble-cut filter in audio applications. A low-pass filter is the complement of a high-pass filter. In optics, high-pass and low-pass may have different meanings, depending on whether referring to the frequency or wavelength of light, since these variables are inversely related. High-pass frequency filters would act as low-pass wavelength filters, and vice versa. For this reason, it is a good practice to refer to wavelength filters as ''short-pass'' and ''long-pass'' to avoid confusion, which would correspond to ''high-pass'' and ''low-pass'' frequencies. Low-pass filters exist in many different forms, including electronic circuits such as a '' hiss filter'' used in audio, ...
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Convolution
In mathematics (in particular, functional analysis), convolution is a operation (mathematics), mathematical operation on two function (mathematics), functions f and g that produces a third function f*g, as the integral of the product of the two functions after one is reflected about the y-axis and shifted. The term ''convolution'' refers to both the resulting function and to the process of computing it. The integral is evaluated for all values of shift, producing the convolution function. The choice of which function is reflected and shifted before the integral does not change the integral result (see #Properties, commutativity). Graphically, it expresses how the 'shape' of one function is modified by the other. Some features of convolution are similar to cross-correlation: for real-valued functions, of a continuous or discrete variable, convolution f*g differs from cross-correlation f \star g only in that either f(x) or g(x) is reflected about the y-axis in convolution; thus i ...
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Recurrent Neural Network
Recurrent neural networks (RNNs) are a class of artificial neural networks designed for processing sequential data, such as text, speech, and time series, where the order of elements is important. Unlike feedforward neural networks, which process inputs independently, RNNs utilize recurrent connections, where the output of a neuron at one time step is fed back as input to the network at the next time step. This enables RNNs to capture temporal dependencies and patterns within sequences. The fundamental building block of RNNs is the ''recurrent unit'', which maintains a ''hidden state''—a form of memory that is updated at each time step based on the current input and the previous hidden state. This feedback mechanism allows the network to learn from past inputs and incorporate that knowledge into its current processing. RNNs have been successfully applied to tasks such as unsegmented, connected handwriting recognition, speech recognition, natural language processing, and neural ...
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Convolutional Neural Network
A convolutional neural network (CNN) is a type of feedforward neural network that learns features via filter (or kernel) optimization. This type of deep learning network has been applied to process and make predictions from many different types of data including text, images and audio. Convolution-based networks are the de-facto standard in deep learning-based approaches to computer vision and image processing, and have only recently been replaced—in some cases—by newer deep learning architectures such as the transformer. Vanishing gradients and exploding gradients, seen during backpropagation in earlier neural networks, are prevented by the regularization that comes from using shared weights over fewer connections. For example, for ''each'' neuron in the fully-connected layer, 10,000 weights would be required for processing an image sized 100 × 100 pixels. However, applying cascaded ''convolution'' (or cross-correlation) kernels, only 25 weights for each convolutio ...
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