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Streptomyces Tenebrarius
''Streptoalloteichus tenebrarius'' is a bacterium that biosynthesizes the aminoglycoside antibiotics tobramycin Tobramycin is an aminoglycoside antibiotic derived from '' Streptomyces tenebrarius'' that is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of ''Pseudomonas ... and apramycin. References Streptomyces {{Streptomyces-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminoglycoside
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside ( sugar). The term can also refer more generally to any organic molecule that contains amino sugar substructures. Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria.ME Levison, MD, 2012, Aminoglycosides, The Merck Manua accessed 22 February 2014. Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from ''Streptomyces griseus'' and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class. Other examples of aminoglycosides include the deoxystreptamine-containi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tobramycin
Tobramycin is an aminoglycoside antibiotic derived from ''Streptomyces tenebrarius'' that is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of ''Pseudomonas''. It was patented in 1965, and approved for medical use in 1974. It is on the World Health Organization's List of Essential Medicines. Medical uses Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or by injection into a muscle. Eye drops and ointments (tobramycin only, Tobrex, or combined with dexamethasone, sold as Tobradex) and nebulised formulations both have low systemic absorption. The formulation for injection is branded Nebcin. The nebulised formulation (brand name Tobi) is indicated in the treatment of exacerbations of chronic infection with ''Pseudomonas aeruginosa'' in people diagnosed with cystic fibrosis. Tobrex eye drops are a 0. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apramycin
Apramycin (also ''Nebramycin II'') is an aminoglycoside antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ... used in veterinary medicine. It is produced by '' Streptomyces tenebrarius''. Spectrum of bacterial susceptibility and resistance Apramycin can be used to treat bacterial infections in animals caused by ''Escherichia coli, Klebsiella pneumoniae'', and ''Pseudomonas aeruginosa''. The following shows susceptibility data on medically significant organisms: * Escherichia coli - 1 μg/mL - >512 μg/mL (this large range may be due to resistant organisms, typical MIC values are likely in the range of 2 -8 μg/mL. * Klebsiella pneumoniae - 2 μg/mL - >256 μg/mL * Pseudomonas aeruginosa - 4 μg/mL References {{AminoglycosideAntiBiotics Aminoglycoside antibiotics [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
