Steven R. Little
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Steven R. Little
Steven R. Little (born 1977) is an American chemical engineer and pharmaceutical scientist. He currently holds the title of department chair, distinguished professor, and George M. and Eva M. Bevier Endowed Chair of Chemical Engineering at the University of Pittsburgh Swanson School of Engineering. He also holds secondary appointments in bioengineering, pharmaceutical sciences, immunology, ophthalmology and the McGowan Institute for Regenerative Medicine at the University of Pittsburgh. Education Little received his BS in chemical engineering from Youngstown State University, and PhD from the Massachusetts Institute of Technology, studying under Institute Professor Robert S. Langer. His dissertation was “''Poly(β-Amino Ester)s as pH Sensitive Biomaterials for Microparticulate Genetic Vaccine Delivery''.” Research Following his PhD in 2005, Little joined the faculty at the University of Pittsburgh John A. Swanson School of Engineering in 2006 as an assistant professor. He w ...
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Controlled Release
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release R, XR, XLdosage) or to a specific target in the body (targeted-release dosage).Pharmaceutics: Drug Delivery and Targeting
p. 7-13
Sustained-release dosage forms are s designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentrat ...
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Bioengineering
Biological engineering or bioengineering is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products. Biological engineering employs knowledge and expertise from a number of pure and applied sciences, such as mass transfer, mass and heat transfer, Kinetics (physics), kinetics, biocatalysts, biomechanics, bioinformatics, separation process, separation and List of purification methods in chemistry, purification processes, bioreactor design, surface science, fluid mechanics, thermodynamics, and polymer science. It is used in the design of medical devices, diagnostic equipment, biocompatible materials, renewable energy, ecological engineering, agricultural engineering, process engineering and catalysis, and other areas that improve the living standards of societies. Examples of bioengineering research include bacteria engineered to produce chemicals, new medical imaging technology, portable and rapid diagnosti ...
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American Heart Association
The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate Heart, cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke. They are known for publishing guidelines on cardiovascular disease and prevention, standards on basic life support, advanced cardiac life support (ACLS), pediatric advanced life support (PALS), and in 2014 issued the first guidelines for preventing strokes in women. The American Heart Association is also known for operating a number of highly visible public service campaigns starting in the 1970s, and also operates several fundraising events. Originally formed in Chicago in 1924, the American Heart Association is currently headquartered in Dallas, Texas. It was originally headquartered in New York City. The American Heart Association is a national voluntary health agency. The mission ...
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National Academy Of Inventors
The National Academy of Inventors (NAI) is a US non-profit organization dedicated to encouraging inventors in academia, following the model of the National Academies of the United States. It was founded at the University of South Florida in 2010. Starting in 2012, the NAI has inducted 757 Fellows into the organization. Fellows must be named as an inventor on at least one US patent and are selected by the NAI Fellows Committee. The NAI also includes colleges and universities as institutional members, beginning with 9 such institutions in 2012; it now has over 200, including 30 outside the United States.. Since 2013, the National Academy of Inventors and the Intellectual Property Owners Association have released an annual report listing the top 100 universities by the number of US patents. The University of California has topped the list each year. The NAI has held a yearly national conference since 2011. In 2017, US Representative Dennis A. Ross Dennis Alan Ross (born ...
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American Association For The Advancement Of Science
The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education, scientific education and science outreach for the betterment of all humanity. AAAS was the first permanent organization established to promote science and engineering nationally and to represent the interests of American researchers from across all scientific fields. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal ''Science (journal), Science''. History Creation The American Association for the Advancement of Science was created on September 20, 1848, at the Academy of Natural Sciences in Philadelphia, Pennsylvania. It was a reformation of the Association of American Geologists and Naturalists with the broaden ...
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American Institute For Medical And Biological Engineering
The American Institute for Medical and Biological Engineering (AIMBE) is a non-profit organization founded in 1991, and headquartered in Washington, D.C. It represents 50,000 medical and Biomedical engineering, biomedical engineers, and academic institutions, private industry, and professional engineering societies. College of Fellows Since AIMBE's inception, over 2,500 individuals have been inducted to AIMBE's College of Fellows. These fellows include heads of medical and engineering schools. Some Fellows work for the government, acting as consultants, or directing clinical trials. Some Fellows are members of other prominent academic institutions, such as the National Academy of Engineering, Institute of Medicine and the United States National Academy of Sciences, National Academy of Sciences. Others have received the National Medal of Science and the National Medal of Technology. Fellows elect a Chair of the College of Fellows, who presides over the election and induction of the ...
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Biomedical Engineering Society
BMES (the Biomedical Engineering Society) is the professional society for students, faculty, researchers and industry working in the broad area of biomedical engineering. BMES is the leading biomedical engineering society in the United States and was founded on February 1, 1968 "to promote the increase of biomedical engineering Biomedical engineering (BME) or medical engineering is the application of engineering principles and design concepts to medicine and biology for healthcare applications (e.g., diagnostic or therapeutic purposes). BME also integrates the logica ... knowledge and its utilization." There are 7,000 members in 2018. Since 1972, the society has published an academic journal, the ''Annals of Biomedical Engineering''online archive. History The BMES was first established in Illinois on February 1, 1968 as a non-profit organization that aims to serve the biomedical engineering students, academics, researchers, and professionals. Upon establishing the organiza ...
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Benedum Hall
Michael L. Benedum Hall of Engineering is a landmark academic building on the campus of the University of Pittsburgh in Pittsburgh, Pennsylvania, United States. The building was designed in the brutalist style by the architectural firm of Deeter, Ritchey, and Sippel and completed in 1971 at a cost of $15 million ($ million today). The building was honored with both the Pennsylvania Society American Institute of Architects Honor Award and Distinguished Building Award. It was built with a gift from the Claude Worthington Benedum Foundation and funds from the General State Authority. It stands on a site that was formerly occupied by the National Guard's Logan Armory. It is fifteen stories (two below ground) and has of space. It is home to the Swanson School of Engineering and contains classrooms, laboratories, offices, conference and seminar rooms, and is home to the George M. Bevier Engineering Library which serves not only the engineering school, but also the Department of ...
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Organ Transplantation
Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source. Organs that have been successfully transplanted include the heart, kidneys, liver, lungs, pancreas, intestine, thymus and uterus. Tissues include bones, tendons (both referred to as musculoskeletal grafts), corneae, skin, heart valves, nerves and veins. Worldwide, the kidneys are the most commonly transplanted organs, followed by the liver and then the heart. J. Hartwell Harrison performed the first organ removal for transplant ...
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Type I Diabetes
Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that occurs when the body's immune system destroys pancreatic cells (beta cells). In healthy persons, beta cells produce insulin. Insulin is a hormone required by the body to store and convert blood sugar into energy. T1D results in high blood sugar levels in the body prior to treatment. Common symptoms include frequent urination, increased thirst, increased hunger, weight loss, and other complications. Additional symptoms may include blurry vision, tiredness, and slow wound healing (owing to impaired blood flow). While some cases take longer, symptoms usually appear within weeks or a few months. The cause of type 1 diabetes is not completely understood, but it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves an autoimmune destruction of the insulin-producing beta cells in the pancreas. Diabetes is diagnosed by testing the level of su ...
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Cancer
Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible Signs and symptoms of cancer, signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in defecation, bowel movements. While these symptoms may indicate cancer, they can also have other causes. List of cancer types, Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor Diet (nutrition), diet, sedentary lifestyle, lack of physical activity or Alcohol abuse, excessive alcohol consumption. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. infectious causes of cancer, Infection with specific viruses, bacteria and parasites is an environmental factor cau ...
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Autoimmune Disease
An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated that there are more than 80 recognized autoimmune diseases, with recent scientific evidence suggesting the existence of potentially more than 100 distinct conditions. Nearly any body part can be involved. Autoimmune diseases are a separate class from autoinflammatory diseases. Both are characterized by an immune system malfunction which may cause similar symptoms, such as rash, swelling, or fatigue, but the cardinal cause or mechanism of the diseases is different. A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the adaptive immune system. Symptoms of autoimmune diseases can significantly vary, primarily based on the specific type of the d ...
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