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Steve A. Kay
Steve A. Kay is a British-born chronobiologist who mainly works in the United States. Dr. Kay has pioneered methods to monitor daily gene expression in real time and characterized circadian gene expression in plants, flies and mammals. In 2014, Steve Kay celebrated 25 years of successful chronobiology research at the Kaylab 25 Symposium, joined by over one hundred researchers with whom he had collaborated with or mentored. Dr. Kay, a member of the National Academy of Sciences, U.S.A., briefly served as president of The Scripps Research Institute. and is currently a professor at the University of Southern California. He also served on the Life Sciences jury for the Infosys Prize in 2011. Life Early life and influences Steve A. Kay was raised on the Isle of Jersey off the coast of Normandy. As a young child, he was fascinated by marine creatures exposed during low tide on Jersey island. His interest in biology deepened when an elementary teacher brought a microscope from mainlan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jersey
Jersey ( , ; nrf, Jèrri, label=Jèrriais ), officially the Bailiwick of Jersey (french: Bailliage de Jersey, links=no; Jèrriais: ), is an island country and self-governing Crown Dependencies, Crown Dependency near the coast of north-west France. It is the largest of the Channel Islands and is from the Cotentin Peninsula in Normandy. The Bailiwick consists of the main island of Jersey and some surrounding uninhabited islands and rocks including Les Dirouilles, Écréhous, Les Écréhous, Minquiers, Les Minquiers, and Pierres de Lecq, Les Pierres de Lecq. Jersey was part of the Duchy of Normandy, whose dukes became kings of England from 1066. After Normandy was lost by the kings of England in the 13th century, and the ducal title surrendered to France, Jersey remained loyal to the The Crown, English Crown, though it never became part of the Kingdom of England. Jersey is a self-governing Parliamentary system, parliamentary democracy under a constitutional monarchy, with its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nam-Hai Chua
Nam-Hai Chua FRS () (born 8 April 1944) is a Singaporean botanist. He is an Andrew W. Mellon Emeritus Professor at Rockefeller University. He is now deputy chairman of Temasek Life Science Laboratory. Life He earned a BS from the National University of Singapore, and an AM and PhD from Harvard University in 1969. He taught at the University of Singapore Medical School, from 1969 to 1971. He was awarded the International Prize for Biology The is an annual award for "outstanding contribution to the advancement of research in fundamental biology." The Prize, although it is not always awarded to a biologist, is one of the most prestigious honours a natural scientist can receive. Ther ... in 2005. He joined Rockefeller University in 1973 and remained there till his retirement from the university. Thereafter, he moved back to Singapore in 2016. Awards and honors * Royal Society of London (1988) * Taiwan Academica Sinica (1988) * Chinese Academy of Sciences (2006) * Honorary Doctorat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomics Institute Of The Novartis Research Foundation
Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-locations It is one of the largest pharmaceutical companies in the world. Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), cyclosporine (Neoral/Sandimmune), letrozole (Femara), methylphenidate (Ritalin; production ceased 2020), terbinafine (Lamisil), deferasirox (Exjade), and others. In March 1996, the companies Ciba-Geigy and Sandoz merged to form Novartis; the pharmaceutical and agrochemical divisions of both companies formed Novartis as an independent entity. Other Ciba-Geigy and Sandoz businesses were sold, or, like Ciba Specialty Chemicals, spun off as independent companies. The Sandoz brand ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scripps Research Institute
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. The institute holds over 1,100 patents, has produced 11 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world. The Scripps Research graduate program is ranked 9th nationally in the biological sciences, 6th for organic chemistry, and 6th for biochemistry. In 2022, their Jupiter, FL campus became a part of the University of Florida. Jupiter-bas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BMAL1
Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or brain and muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the gene on chromosome 11, region p15.3. It's also known as ''BMAL1'', ''MOP3'', and, less commonly, ''bHLHe5'', ''BMAL'', ''BMAL1C'', ''JAP3'', ''PASD3'', and ''TIC''. ''ARNTL'' encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human ''ARNTL'' gene has a predicted 24 exons, located on the p15 band of the Chromosome 11, 11th chromosome. The ARNTL protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory Transcription translation feedback loop, transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. Research has revealed that ''ARNTL'' is the only clock gene without which the circadian clock fails to function in humans. ''ARNTL'' has also been identified as a candida ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CLOCK
A clock or a timepiece is a device used to measure and indicate time. The clock is one of the oldest human inventions, meeting the need to measure intervals of time shorter than the natural units such as the day, the lunar month and the year. Devices operating on several physical processes have been used over the millennia. Some predecessors to the modern clock may be considered as "clocks" that are based on movement in nature: A sundial shows the time by displaying the position of a shadow on a flat surface. There is a range of duration timers, a well-known example being the hourglass. Water clocks, along with the sundials, are possibly the oldest time-measuring instruments. A major advance occurred with the invention of the verge escapement, which made possible the first mechanical clocks around 1300 in Europe, which kept time with oscillating timekeepers like balance wheels., pp. 103–104., p. 31. Traditionally, in horology, the term ''clock'' was used for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Takahashi
Joseph S. Takahashi is a Japanese American neurobiologist and geneticist. Takahashi is a professor at University of Texas Southwestern Medical Center as well as an investigator at the Howard Hughes Medical Institute. Takahashi's research group discovered the genetic basis for the mammalian circadian clock in 1994 and identified the ''Clock'' gene in 1997. Takahashi was elected to the National Academy of Sciences in 2003. Background Takahashi graduated from Richard Montgomery High School in Rockville, Maryland in 1970. Takahashi attended Swarthmore College and graduated with a degree in biology in 1974. He worked with Patricia DeCoursey at the University of South Carolina for a year after graduation and then applied to work with Michael Menaker at the University of Texas, Austin. Menaker ultimately moved to the University of Oregon where Takahashi received his neuroscience Ph.D. in 1981. Takahashi was a postdoctoral fellow at the National Institute of Mental Health for two years ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cryptochrome
Cryptochromes (from the Greek κρυπτός χρώμα, "hidden colour") are a class of flavoproteins found in plants and animals that are sensitive to blue light. They are involved in the circadian rhythms and the sensing of magnetic fields in a number of species. The name ''cryptochrome'' was proposed as a ''portmanteau'' combining the '' chromatic'' nature of the photoreceptor, and the '' cryptogamic'' organisms on which many blue-light studies were carried out. The two genes ''Cry1'' and ''Cry2'' code the two cryptochrome proteins CRY1 and CRY2. In insects and plants, CRY1 regulates the circadian clock in a light-dependent fashion, whereas in mammals, CRY1 and CRY2 act as light-independent inhibitors of CLOCK- BMAL1 components of the circadian clock. In plants, blue-light photoreception can be used to cue developmental signals. Besides chlorophylls, cryptochromes are the only proteins known to form photoinduced radical-pairs '' in vivo''. These appear to enable some a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeffrey C
Jeffrey may refer to: * Jeffrey (name), including a list of people with the name * ''Jeffrey'' (1995 film), a 1995 film by Paul Rudnick, based on Rudnick's play of the same name * ''Jeffrey'' (2016 film), a 2016 Dominican Republic documentary film * Jeffrey's, Newfoundland and Labrador, Canada * Jeffrey City, Wyoming, United States * Jeffrey Street, Sydney, Australia *Jeffrey's sketch, a sketch on American TV show ''Saturday Night Live'' *''Nurse Jeffrey'', a spin-off miniseries from the American medical drama series ''House, MD'' * Jeffreys Bay, Western Cape, South Africa People with the surname * Alexander Jeffrey (1806–1874), Scottish solicitor and historian *Charles Jeffrey (footballer) (died 1915), Scottish footballer *E. C. Jeffrey (1866–1952), Canadian-American botanist * Grant Jeffrey (1948–2012), Canadian writer * Hester C. Jeffrey (1842–1934), American activist, suffragist and community organizer * Richard Jeffrey (1926–2002), American philosopher, logician, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TOC1 (gene)
Timing of CAB expression 1 is a protein that in ''Arabidopsis thaliana'' is encoded by the TOC1 gene. TOC1 is also known as two-component response regulator-like APRR1. TOC1 was the first plant gene that, when mutated, yielded a circadian phenotype. It codes for the transcription factor TOC1, which affects the period of plants' circadian rhythms: built-in, malleable oscillations that repeat every 24 hours. The gene codes for a transcriptional repressor, TOC1, one of five pseudo-response regulators (PRR) that mediate the period of the circadian clock in plants. The TOC1 protein is involved in the clock's evening loop, which is a repressilator that directly inhibits transcription of morning loop genes LHY and CCA1. Toc1 gene is expressed in most plant structures and cells, and has its locus on chromosome 5. Historical context Discovery The TOC1 gene was initially discovered by Prof. Andrew Millar and colleagues in 1995 while Millar was a graduate student. Millar develo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andrew Millar (scientist)
Andrew John McWalter Millar, FRS, FRSE is a Scottish chronobiologist, systems biologist, and molecular geneticist. Millar is a professor at The University of Edinburgh and also serves as its chair of systems biology. Millar is best known for his contributions to plant circadian biology; in the Steve Kay lab, he pioneered the use of luciferase imaging to identify circadian mutants in ''Arabidopsis''. Additionally, Millar's group has implicated the '' ELF4'' gene in circadian control of flowering time in ''Arabidopsis''. Millar was elected to the Royal Society in 2012 and the Royal Society of Edinburgh in 2013. Life Andrew Millar was raised in Luxembourg. He later attended Cambridge University where he received a Bachelor of Arts in 1988, studying genetics and winning University Prizes for botany in 1987 and genetics in 1988. After graduation, he began doctoral study in the United States at The Rockefeller University under the mentorship of Nam-Hai Chua, FRS, and graduated i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arabidopsis Thaliana
''Arabidopsis thaliana'', the thale cress, mouse-ear cress or arabidopsis, is a small flowering plant native to Eurasia and Africa. ''A. thaliana'' is considered a weed; it is found along the shoulders of roads and in disturbed land. A winter annual with a relatively short lifecycle, ''A. thaliana'' is a popular model organism in plant biology and genetics. For a complex multicellular eukaryote, ''A. thaliana'' has a relatively small genome around 135 megabase pairs. It was the first plant to have its genome sequenced, and is a popular tool for understanding the molecular biology of many plant traits, including flower development and light sensing. Description ''Arabidopsis thaliana'' is an annual (rarely biennial) plant, usually growing to 20–25 cm tall. The leaves form a rosette at the base of the plant, with a few leaves also on the flowering stem. The basal leaves are green to slightly purplish in color, 1.5–5 cm long, and 2–10 mm broad, wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
