Spi-1 (PU.1) 5′ UTR Regulatory Element
The Spi-1 (PU.1) 5′ UTR regulatory element is an cis-regulatory element, RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the Translation (biology), translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during Haematopoiesis, haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia. See also *Invasion gene associated RNA (InvR), InvR References External links

* Cis-regulatory RNA elements {{molecular-cell-biology-stub ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  

Secondary Structure
Protein secondary structure is the three dimensional form of ''local segments'' of proteins. The two most common secondary structural elements are alpha helices and beta sheets, though beta turns and omega loops occur as well. Secondary structure elements typically spontaneously form as an intermediate before the protein folds into its three dimensional tertiary structure. Secondary structure is formally defined by the pattern of hydrogen bonds between the amino hydrogen and carboxyl oxygen atoms in the peptide backbone. Secondary structure may alternatively be defined based on the regular pattern of backbone dihedral angles in a particular region of the Ramachandran plot regardless of whether it has the correct hydrogen bonds. The concept of secondary structure was first introduced by Kaj Ulrik Linderstrøm-Lang at Stanford in 1952. Other types of biopolymers such as nucleic acids also possess characteristic secondary structures. Types The most common secondary st ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]