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Spi-1
Transcription factor PU.1 is a protein that in humans is encoded by the ''SPI1'' gene. Function This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. Structure The ETS domain is the DNA-binding module of PU.1 and other ETS-family transcription factors. Interactions SPI1 has been shown to Protein-protein interaction, interact with: * FUS (gene), FUS, * GATA2, * IRF4, and * NONO. References Further reading * * * * * * * * * * * * * * * * * * * External links * Transcription factors {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FUS (gene)
RNA-binding protein FUS/TLS (FUused in Sarcoma/Translocated in LipoSarcoma), also known as heterogeneous nuclear ribonucleoprotein P2 is a protein that in humans is encoded by the ''FUS'' gene. Discovery FUS/TLS was initially identified as a fusion protein (FUS-CHOP) produced as a result of chromosomal translocations in human cancers, especially liposarcomas. In these instances, the promoter and N-terminal part of FUS/TLS is translocated to the C-terminal domain of various DNA-binding transcription factors (e.g. CHOP) conferring a strong transcriptional activation domain onto the fusion proteins. FUS/TLS was independently identified as the hnRNP P2 protein, a subunit of a complex involved in the maturation of pre-mRNA. Structure FUS/TLS is a member of the FET protein family that also includes the EWS protein, the TATA-binding protein TBP-associated factor TAFII68/ TAF15, and the Drosophila cabeza/SARF protein. FUS/TLS, EWS and TAF15 have a similar structure, character ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |