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Sliding Filament Mechanism
The sliding filament theory explains the mechanism of muscle contraction based on muscle proteins that slide past each other to generate movement. According to the sliding filament theory, the myosin ( thick filaments) of muscle fibers slide past the actin ( thin filaments) during muscle contraction, while the two groups of filaments remain at relatively constant length. The theory was independently introduced in 1954 by two research teams, one consisting of Andrew Huxley and Rolf Niedergerke from the University of Cambridge, and the other consisting of Hugh Huxley and Jean Hanson from the Massachusetts Institute of Technology. It was originally conceived by Hugh Huxley in 1953. Andrew Huxley and Niedergerke introduced it as a "very attractive" hypothesis. Before the 1950s there were several competing theories on muscle contraction, including electrical attraction, protein folding, and protein modification. The novel theory directly introduced a new concept called cross-bridg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarcomere
A sarcomere (Greek σάρξ ''sarx'' "flesh", μέρος ''meros'' "part") is the smallest functional unit of striated muscle tissue. It is the repeating unit between two Z-lines. Skeletal striated muscle, Skeletal muscles are composed of tubular muscle cells (called muscle fibers or myofibers) which are formed during embryonic development, embryonic myogenesis. Muscle fibers contain numerous tubular myofibrils. Myofibrils are composed of repeating sections of sarcomeres, which appear under the microscope as alternating dark and light bands. Sarcomeres are composed of long, fibrous proteins as filaments that slide past each other when a muscle contracts or relaxes. The costamere is a different component that connects the sarcomere to the sarcolemma. Two of the important proteins are myosin, which forms the thick filament, and actin, which forms the thin filament. Myosin has a long fibrous tail and a globular head that binds to actin. The myosin head also binds to Adenosine triphos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Willy Kuhne
Willy or Willie is a masculine, male given name, often a diminutive form of William or Wilhelm, and occasionally a nickname. It may refer to: People Given name or nickname * Willie Allen (basketball) (born 1949), American basketball player and director of the Growing Power urban farming program * Willie Allen (racing driver) (born 1980), American racing driver * Willie Anderson (other) * Willie Apiata (born 1972), New Zealand Army soldier, the only recipient of the Victoria Cross for New Zealand * Willie (footballer) (born 1993), Brazilian footballer Willie Hortencio Barbosa * Willy Böckl (1893–1975), Austrian world champion figure skater * Willy Bocklant (1941–1985), Belgian road racing cyclist * Willy Bogner Sr. (1909–1977), German Nordic skier * Willy Bogner Jr. (born 1942), German fashion designer and alpine skier * Willie Bosket (born 1962), an American convicted murderer whose numerous crimes committed as a minor led to a change in New York state law * Wil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarcomere
A sarcomere (Greek σάρξ ''sarx'' "flesh", μέρος ''meros'' "part") is the smallest functional unit of striated muscle tissue. It is the repeating unit between two Z-lines. Skeletal striated muscle, Skeletal muscles are composed of tubular muscle cells (called muscle fibers or myofibers) which are formed during embryonic development, embryonic myogenesis. Muscle fibers contain numerous tubular myofibrils. Myofibrils are composed of repeating sections of sarcomeres, which appear under the microscope as alternating dark and light bands. Sarcomeres are composed of long, fibrous proteins as filaments that slide past each other when a muscle contracts or relaxes. The costamere is a different component that connects the sarcomere to the sarcolemma. Two of the important proteins are myosin, which forms the thick filament, and actin, which forms the thin filament. Myosin has a long fibrous tail and a globular head that binds to actin. The myosin head also binds to Adenosine triphos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-ray Diffraction
X-ray diffraction is a generic term for phenomena associated with changes in the direction of X-ray beams due to interactions with the electrons around atoms. It occurs due to elastic scattering, when there is no change in the energy of the waves. The resulting map of the directions of the X-rays far from the sample is called a diffraction pattern. It is different from X-ray crystallography which exploits X-ray diffraction to determine the arrangement of atoms in materials, and also has other components such as ways to map from experimental diffraction measurements to the positions of atoms. This article provides an overview of X-ray diffraction, starting with the early #History, history of x-rays and the discovery that they have the right spacings to be diffracted by crystals. In many cases these diffraction patterns can be #Introduction to x-ray diffraction theory, Interpreted using a single scattering or kinematical theory with conservation of energy (#Ewald's sphere, wave vecto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
King's College London
King's College London (informally King's or KCL) is a public university, public research university in London, England. King's was established by royal charter in 1829 under the patronage of George IV of the United Kingdom, King George IV and the Arthur Wellesley, 1st Duke of Wellington, Duke of Wellington. In 1836, King's became one of the two founding colleges of the University of London. It is one of the Third-oldest university in England debate, oldest university-level institutions in England. In the late 20th century, King's grew through a series of mergers, including with Queen Elizabeth College and Chelsea College of Science and Technology (1985), the Institute of Psychiatry (1997), the United Medical and Dental Schools of Guy's and St Thomas' Hospitals and the Florence Nightingale School of Nursing and Midwifery (in 1998). King's operates across five main campuses: the historic Strand Campus in central London, three other Thames-side campuses (Guy's, St Thomas' an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francis O
Francis may refer to: People and characters *Pope Francis, head of the Catholic Church (2013–2025) *Francis (given name), including a list of people and fictional characters * Francis (surname) * Francis, a character played by YouTuber Boogie2988 Places * Rural Municipality of Francis No. 127, Saskatchewan, Canada * Francis, Saskatchewan, Canada ** Francis (electoral district) * Francis, Nebraska, USA * Francis Township, Holt County, Nebraska, USA * Francis, Oklahoma, USA * Francis, Utah, USA Arts, entertainment, media * ''Francis'' (film), the first of a series of comedies featuring Francis the Talking Mule, voiced by Chill Wills *''Francis'', a 1983 play by Julian Mitchell * Francis (band), a Sweden-based folk band *Francis (TV series), a Indian Bengali-language animated television series Other uses *FRANCIS, a bibliographic database * ''Francis'' (1793), a colonial schooner in Australia *Francis turbine, a type of water turbine See also *Saint Francis (other) * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Archibald Hill
Archibald Vivian Hill (26 September 1886 – 3 June 1977), better known to friends and colleagues as A. V. Hill, was a British physiologist, one of the founders of the diverse disciplines of biophysics and operations research. He shared the 1922 Nobel Prize in Physiology or Medicine for his elucidation of the production of heat and mechanical work in muscles. Biography Born in Bristol, he was educated at Blundell's School and graduated from Trinity College, Cambridge as third wrangler in the mathematics tripos before turning to physiology. While still an undergraduate at Trinity College, he derived in 1909 what came to be known as the Langmuir equation. This is closely related to Michaelis–Menten kinetics. In this paper, Hill's first publication, he derived both the equilibrium form of the Langmuir equation, and also the exponential approach to equilibrium. The paper, written under the supervision of John Newport Langley, is a landmark in the history of receptor theory, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Otto Fritz Meyerhof
Otto Fritz Meyerhof (; 12 April 1884 – 6 October 1951) was a German physician and biochemist who won the 1922 Nobel Prize in Physiology and Medicine. Biography Otto Fritz Meyerhof was born in Hannover, at Theaterplatz 16A (now:Rathenaustrasse 16A), the son of wealthy Jewish parents. In 1888, his family moved to Berlin, where Otto spent most of his childhood, and where he started his study of medicine. He continued these studies in Strasbourg and Heidelberg, from which he graduated in 1909, with a work titled "Contributions to the Psychological Theory of Mental Illness". In Heidelberg, he met Hedwig Schallenberg. They married in 1914 and had three children together: a daughter, Bettina, and two sons, Gottfried (who after emigration used the anglicized name Geoffrey) and Walter. In 1912, Otto Meyerhof moved to the University of Kiel, where he received a professorship in 1918. In 1922, he was awarded the Nobel Prize in Medicine, with Archibald Vivian Hill, for his work on mus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brunó Ferenc Straub
Brunó Ferenc Straub (5 January 1914 in Nagyvárad, Austria-Hungary (now Oradea, Romania) – 15 February 1996) was a biochemist. As a young scholar he was a research assistant of Albert Szent-Györgyi at the University of Szeged, and subsequently worked at the Molteno Institute, Cambridge, UK. He was the first to obtain actin in a relatively pure state. He founded the Biological Research Centre in Szeged Szeged ( , ; see also #Etymology, other alternative names) is List of cities and towns of Hungary#Largest cities in Hungary, the third largest city of Hungary, the largest city and regional centre of the Southern Great Plain and the county seat .... He was the chairman of the Hungarian Presidential Council from 29 June 1988 to 23 October 1989. He proposed the theory of conformational selection in 1964, the same year the Monod–Wyman–Changeux model was proposed. References {{DEFAULTSORT:Straub, Bruno Ferenc 1914 births 1996 deaths People from Oradea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fumaric Acid
Fumaric acid or ''trans''-butenedioic acid is an organic compound with the formula HO2CCH=CHCO2H. A white solid, fumaric acid occurs widely in nature. It has a fruit-like taste and has been used as a food additive. Its E number is E297. The salts and esters are known as fumarates. Fumarate can also refer to the ion (in solution). Fumaric acid is the ''trans'' isomer of butenedioic acid, while maleic acid is the ''cis'' isomer. Biosynthesis and occurrence It is produced in eukaryotic organisms from succinate in complex 2 of the electron transport chain via the enzyme succinate dehydrogenase. Fumaric acid is found in fumitory (''Fumaria officinalis''), bolete mushrooms (specifically ''Boletus fomentarius var. pseudo-igniarius''), lichen, and Iceland moss. Fumarate is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food. It is formed by the oxidation of succinate by the enzyme succinate dehydr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitamin C
Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits, berries and vegetables. It is also a generic prescription medication and in some countries is sold as a non-prescription dietary supplement. As a therapy, it is used to prevent and treat scurvy, a disease caused by vitamin C deficiency. Vitamin C is an essential nutrient involved in the repair of tissue, the formation of collagen, and the enzymatic production of certain neurotransmitters. It is required for the functioning of several enzymes and is important for immune system function. It also functions as an antioxidant. Vitamin C may be taken by mouth or by intramuscular, subcutaneous or intravenous injection. Various health claims exist on the basis that moderate vitamin C deficiency increases disease risk, such as for the common cold, cancer or COVID-19. There are also claims of benefits from vitamin C supplementation in excess of the recommended d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Medicine or Physiology, Chemistry, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2024, 115 Nobel Prizes in Physiology or Medicine have been awarded to 229 laureates, 216 men and 13 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucida ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
