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Sleepwell
Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC in the UK. It has relatively strong sedative effects, to the extent that its primary use was as a medication for insomnia rather than for its antihistamine action. Together with scopolamine, it was the main ingredient in Sominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM. All of these products were reformulated in the late 1970s when methapyrilene was demonstrated to cause liver cancer in rats when given chronically. See also *Thenalidine *Methaphenilene Methaphenilene is an antihistamine and anticholinergic. Synthesis Methaphenilene can be synthesized from ''N'',''N''-dimethyl-'-phenylethane-1,2-diamine by alkylation with 2-(chloromethyl)thiophene. See also *Thenalidine *Methapyrilene Me ... References Hepatotoxins Sedatives Thiophenes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thionyl Fluoride
Thionyl fluoride is the inorganic compound with the formula . This colourless gas is mainly of theoretical interest, but it is a product of the degradation of sulfur hexafluoride, an insulator in electrical equipment. The molecule adopts a distorted pyramidal structure, with Cs symmetry. The S-O and S-F distances are 1.42 and 1.58 Å, respectively. The O-S-F and F-S-F angles are 106.2 and 92.2°, respectively. Synthesis and reactions Thionyl fluoride can be produced by the reaction of thionyl chloride with fluoride sources such as antimony trifluoride. : Alternatively, it arises via the fluorination of sulfur dioxide: : Thionyl fluoride arises as a fleeting intermediate from the decomposition of sulfur hexafluoride as the result of electrical discharges which generate sulfur tetrafluoride. SF4 hydrolyzes to give thionyl fluoride, which in turn hydrolyzes further as described below. As expected from the behavior of the other thionyl halides, this compound hydrolyzes readily, g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daily Press (Virginia)
''The Daily Press Inc.'' is a daily morning newspaper published in Newport News, Virginia, which covers the lower and middle Peninsula of Tidewater Virginia. It was established in 1896 and bought by Tribune Company in 1986. Current owner Tribune Publishing spun off from the company in 2014. In 2016, ''The Daily Press'' has a daily average readership of approximately 101,100. It had a Sunday average readership of approximately 169,200. Using a frequently used industry-standard readership of 2.2 readers per copy, the October 2022 readership is estimated to be 38,000. It is the sister newspaper to Norfolk's ''The Virginian-Pilot'', which was its southern market rival until Tribune's purchase of that paper in 2018; the papers have both been based out of the ''Daily Press'' building since May 2020. ''The Daily Press'' is distributed to the following cities and counties: Gloucester, Hampton, Isle of Wight, James City, Newport News, Poquoson, Smithfield, Williamsburg, and York. Thro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiophenes
Thiophene is a heterocyclic compound with the formula C4H4S. Consisting of a planar five-membered ring, it is aromaticity, aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene-like odor. In most of its reactions, it resembles benzene. Compounds analogous to thiophene include furan (C4H4O), selenophene (C4H4Se) and pyrrole (C4H4NH), which each vary by the heteroatom in the ring. Isolation and occurrence Thiophene was discovered by Viktor Meyer in 1882 as a contaminant in benzene. It was observed that isatin (an indole) forms a blue dye if it is mixed with sulfuric acid and crude benzene. The formation of the blue indophenin had long been believed to be a reaction of benzene itself. Viktor Meyer was able to isolate thiophene as the actual substance responsible for this reaction. Thiophene and especially its derivatives occur in petroleum, sometimes in concentrations up to 1–3%. The thiophenic content of Petroleum, oil and coal i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sedatives
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are central nervous system (CNS) depressants and interact with brain activity, causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). Most sedatives produce relaxing effects by increasing GABA activity. This group is related to hypnotics. The term ''sedative'' describes drugs that serve to calm or relieve anxiety, whereas the term ''hypnotic'' describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness), they are often referred to collectively as ''sedative–hypnotic'' drugs. Terminology There is some overlap between the terms "sedative" and "hypnotic". Advances in pharmacol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatotoxins
Hepatotoxicity (from ''hepatic toxicity'') implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in Drug overdose, overdoses (e.g. Paracetamol, acetaminophen, paracetamol) and sometimes even when introduced within Therapeutic index, therapeutic ranges (e.g. halothane), may injure the organ. Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., alpha-amanitin), and Herbalism, herbal remedies (two prominent examples being kava, though the causal mechanism is unknown, and comfrey, through pyrrolizidine alkaloid content) can also induce hepatotoxicity. Chemicals that cause liver injury are called hep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methaphenilene
Methaphenilene is an antihistamine and anticholinergic. Synthesis Methaphenilene can be synthesized from ''N'',''N''-dimethyl-'-phenylethane-1,2-diamine by alkylation with 2-(chloromethyl)thiophene. See also *Thenalidine *Methapyrilene Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC in the UK. It has relatively strong sedative effects, to the ... References Sedatives Thiophenes Diamines H1 receptor antagonists {{sedative-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thenalidine
Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria .... References H1 receptor antagonists Piperidines Thiophenes Anilines Withdrawn drugs {{dermatologic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'' is the peer review, peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' cover the full range of List of academ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver Cancer
Liver cancer, also known as hepatic cancer, primary hepatic cancer, or primary hepatic malignancy, is cancer that starts in the liver. Liver cancer can be primary in which the cancer starts in the liver, or it can be liver metastasis, or secondary, in which the cancer spreads from elsewhere in the body to the liver. Liver metastasis is the more common of the two liver cancers. Instances of liver cancer are increasing globally. Primary liver cancer is globally the sixth-most frequent cancer and the fourth-leading cause of death from cancer. In 2018, it occurred in 841,000 people and resulted in 782,000 deaths globally. Higher rates of liver cancer occur where hepatitis B and C are common, including Asia and sub-Saharan Africa. Males are more often affected with hepatocellular carcinoma (HCC) than females. Diagnosis is most frequent among those 55 to 65 years old. The leading cause of liver cancer is cirrhosis due to hepatitis B, hepatitis C, or alcohol. Other causes include af ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Star Tribune
''The Minnesota Star Tribune'', formerly the ''Minneapolis Star Tribune'', is an American daily newspaper based in Minneapolis, Minnesota. As of 2023, it is Minnesota's largest newspaper and the List of newspapers in the United States, seventh-largest in the United States by circulation, and is distributed throughout the Minneapolis–Saint Paul metropolitan area, the state, and the Upper Midwest. It originated as the ''Minneapolis Tribune'' in 1867 and the competing ''Minneapolis Daily Star'' in 1920. During the 1930s and 1940s, the two papers consolidated, with the ''Tribune'' published in the morning and the ''Star'' in the evening. They merged in 1982, creating the ''Minneapolis Star and Tribune'', renamed the ''Star Tribune'' in 1987. After a tumultuous period in which the newspaper was sold and resold and filed for Bankruptcy in the United States, bankruptcy protection in 2009, it was purchased by local billionaire and former Minnesota State Senator Glen Taylor in 2014. I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Newspapers
A newspaper is a Periodical literature, periodical publication containing written News, information about current events and is often typed in black ink with a white or gray background. Newspapers can cover a wide variety of fields such as politics, business, sports, art, and science. They often include materials such as opinion columns, weather forecasts, reviews of local services, Obituary, obituaries, birth notices, crosswords, editorial cartoons, comic strips, and advice columns. Most newspapers are businesses, and they pay their expenses with a mixture of Subscription business model, subscription revenue, Newsagent's shop, newsstand sales, and advertising revenue. The journalism organizations that publish newspapers are themselves often Metonymy, metonymically called newspapers. Newspapers have traditionally been published Printing, in print (usually on cheap, low-grade paper called newsprint). However, today most newspapers are also Electronic publishing, published on webs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
