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Shimon Schuldiner
Shimon Schuldiner (; born August 10, 1946) is an Israeli biochemist. He has made important contributions to the understanding of proteins that couple the movement of ions and other molecules across membranes. Schuldiner is Mathilda Marks-Kennedy Professor at the Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem. He received a B.Sc. in 1967 and an M.Sc. in 1968 from the Hebrew University of Jerusalem, and a Ph.D. from the Weizmann Institute of Science in Rehovot in 1973. Biography Schuldiner was born on August 10, 1946, in Buenos Aires, Argentina, to Hana Joszpe and Berko Schuldiner, who were Jewish immigrants from Ukraine. In 1964 he emigrated to Israel, where he has been living since. He earned a B.Sc. in 1967 and a M.Sc. in 1968 from the Hebrew University of Jerusalem, the latter working with Itzhak Ohad. In 1973 he received a Ph.D. for work performed in the laboratory of Mordhay Avron (z"l) at the Weizmann Institute of Science in Rehovot . Fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buenos Aires
Buenos Aires, controlled by the government of the Autonomous City of Buenos Aires, is the Capital city, capital and largest city of Argentina. It is located on the southwest of the Río de la Plata. Buenos Aires is classified as an Alpha− global city, according to the Globalization and World Cities Research Network, GaWC 2024 ranking. The city proper has a population of 3.1 million and its urban area 16.7 million, making it the List of metropolitan areas, twentieth largest metropolitan area in the world. It is known for its preserved eclecticism, eclectic European #Architecture, architecture and rich culture, cultural life. It is a multiculturalism, multicultural city that is home to multiple ethnic and religious groups, contributing to its culture as well as to the dialect spoken in the city and in some other parts of the country. This is because since the 19th century, the city, and the country in general, has been a major recipient of millions of Immigration to Argentina, im ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ukraine
Ukraine is a country in Eastern Europe. It is the List of European countries by area, second-largest country in Europe after Russia, which Russia–Ukraine border, borders it to the east and northeast. Ukraine also borders Belarus to the north; Poland and Slovakia to the west; Hungary, Romania and Moldova to the southwest; and the Black Sea and the Sea of Azov to the south and southeast. Kyiv is the nation's capital and List of cities in Ukraine, largest city, followed by Kharkiv, Odesa, and Dnipro. Ukraine's official language is Ukrainian language, Ukrainian. Humans have inhabited Ukraine since 32,000 BC. During the Middle Ages, it was the site of early Slavs, early Slavic expansion and later became a key centre of East Slavs, East Slavic culture under the state of Kievan Rus', which emerged in the 9th century. Kievan Rus' became the largest and most powerful realm in Europe in the 10th and 11th centuries, but gradually disintegrated into rival regional powers before being d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hebrew University Of Jerusalem Alumni
Hebrew (; ''ʿÎbrit'') is a Northwest Semitic language within the Afroasiatic language family. A regional dialect of the Canaanite languages, it was natively spoken by the Israelites and remained in regular use as a first language until after 200 CE and as the liturgical language of Judaism (since the Second Temple period) and Samaritanism. The language was revived as a spoken language in the 19th century, and is the only successful large-scale example of linguistic revival. It is the only Canaanite language, as well as one of only two Northwest Semitic languages, with the other being Aramaic, still spoken today. The earliest examples of written Paleo-Hebrew date back to the 10th century BCE. Nearly all of the Hebrew Bible is written in Biblical Hebrew, with much of its present form in the dialect that scholars believe flourished around the 6th century BCE, during the time of the Babylonian captivity. For this reason, Hebrew has been referred to by Jews as '' Las ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academic Staff Of The Hebrew University Of Jerusalem
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of tertiary education. The name traces back to Plato's school of philosophy, founded approximately 386 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. The Royal Spanish Academy defines academy as scientific, literary or artistic society established with public authority and as a teaching establishment, public or private, of a professional, artistic, technical or simply practical nature. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, ''Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Israeli Biochemists
Israeli may refer to: * Something of, from, or related to the State of Israel * Israelis, citizens or permanent residents of the State of Israel * Modern Hebrew, a language * ''Israeli'' (newspaper), published from 2006 to 2008 * Guni Israeli (born 1984), Israeli basketball player See also * Israel (other) * Israelites (other), the ancient people of the Land of Israel * List of Israelis Israelis ( ''Yiśraʾelim'') are the citizens or permanent residents of the State of Israel. The largest ethnic groups in Israel are Israeli Jews, Jews (75%), followed by Arab-Israelis, Palestinians and Arabs (20%) and other minorities (5%). _ ... {{disambiguation Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1946 Births
1946 (Roman numerals, MCMXLVI) was a common year starting on Tuesday of the Gregorian calendar, the 1946th year of the Common Era (CE) and ''Anno Domini'' (AD) designations, the 946th year of the 2nd millennium, the 46th year of the 20th century, and the 7th year of the 1940s decade. Events January * January 6 – The 1946 North Vietnamese parliamentary election, first general election ever in Vietnam is held. * January 7 – The Allies of World War II recognize the Austrian republic with its 1937 borders, and divide the country into four Allied-occupied Austria, occupation zones. * January 10 ** The first meeting of the United Nations is held, at Methodist Central Hall Westminster in London. ** ''Project Diana'' bounces radar waves off the Moon, measuring the exact distance between the Earth and the Moon, and proves that communication is possible between Earth and outer space, effectively opening the Space Age. * January 11 – Enver Hoxha declares the People's Republic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VMAT
The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters into synapses, as chemical messages to postsynaptic neurons. VMATs utilize a proton gradient generated by V-ATPases in vesicle membranes to power monoamine import. Pharmaceutical drugs that target VMATs have possible applications for many conditions, leading to a plethora of biological research, including hypertension, drug addiction, psychiatric disorders, Parkinson's disease, and other neurological disorders. Many drugs that target VMATs act as inhibitors and alter the kinetics of the protein. Much research regarding the effects of altered VMATs on biological systems is still ongoing. Monoamines Monoamines transported by VMATs are mainly noradrenaline, adrenaline, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topologically
Topology (from the Greek words , and ) is the branch of mathematics concerned with the properties of a geometric object that are preserved under continuous deformations, such as stretching, twisting, crumpling, and bending; that is, without closing holes, opening holes, tearing, gluing, or passing through itself. A topological space is a set endowed with a structure, called a ''topology'', which allows defining continuous deformation of subspaces, and, more generally, all kinds of continuity. Euclidean spaces, and, more generally, metric spaces are examples of topological spaces, as any distance or metric defines a topology. The deformations that are considered in topology are homeomorphisms and homotopies. A property that is invariant under such deformations is a topological property. The following are basic examples of topological properties: the dimension, which allows distinguishing between a line and a surface; compactness, which allows distinguishing between a line a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Dimer
In biochemistry, a protein dimer is a macromolecular complex or protein multimer, multimer formed by two protein monomers, or single proteins, which are usually Non-covalent interaction, non-covalently bound. Many macromolecules, such as proteins or nucleic acids, form dimers. The word ''dimer'' has roots meaning "two parts", ''wikt:di-#Prefix, di-'' + ''wikt:-mer#Suffix, -mer''. A protein dimer is a type of protein quaternary structure. A protein homodimer is formed by two identical proteins while a protein heterodimer is formed by two different proteins. Most protein dimers in biochemistry are not connected by covalent bonds. An example of a non-covalent heterodimer is the enzyme reverse transcriptase, which is composed of two different amino acid chains. An exception is dimers that are linked by disulfide bridges such as the homodimeric protein IKBKG, NEMO. Some proteins contain specialized domains to ensure dimerization (dimerization domains) and specificity. The G protein- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiporter
An antiporter (also called exchanger or counter-transporter) is an integral membrane protein that uses secondary active transport to move two or more molecules in opposite directions across a phospholipid membrane. It is a type of cotransporter, which means that uses the Exergonic reaction, energetically favorable movement of one molecule down its electrochemical gradient to power the Endergonic reaction, energetically unfavorable movement of another molecule up its electrochemical gradient. This is in contrast to symporters, which are another type of cotransporter that moves two or more ions in the same direction, and primary active transport, which is directly powered by Adenosine triphosphate, ATP. Transport may involve one or more of each type of solute. For example, the Sodium-calcium exchanger, Na+/Ca2+ exchanger, found in the plasma membrane of many cells, moves three sodium ions in one direction, and one calcium ion in the other. As with sodium in this example, antiport ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Membrane Proteins
Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane and can either penetrate the membrane (Transmembrane protein, transmembrane) or associate with one or the other side of a membrane (Integral monotopic protein, integral monotopic). Peripheral membrane proteins are transiently associated with the cell membrane. Membrane proteins are common, and medically important—about a third of all human proteins are membrane proteins, and these are targets for more than half of all drugs. Nonetheless, compared to other classes of proteins, determining membrane protein structures remains a challenge in large part due to the difficulty in establishing experimental conditions that can preserve the correct (Native state, native) Protein structure, conformation of the protein in isolation from its native ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hadassah Medical School
Hadassah Medical Center () is an Israeli medical organization established in 1934 that operates two university hospitals in Jerusalem (one in Ein Karem and one in Mount Scopus) as well as schools of medicine, dentistry, nursing, and pharmacology affiliated with the Hebrew University of Jerusalem. Its declared mission is to extend a "hand to all, without regard for race, religion or ethnic origin." The hospital was founded by the Hadassah Women's Zionist Organization of America, which continues to underwrite a large part of its budget today. The Medical Center ranks as the sixth-largest hospital complex in Israel. Across its two campuses, Hadassah Medical Center has over 1,300 beds, 31 operating theaters and nine special intensive care units, and runs five schools of medical professions. History Late Ottoman period (1912–1915) The Hadassah organization was established in 1912 in New York City to provide health care in Ottoman Empire, Ottoman-ruled Jerusalem. In 1913, Hadassah sen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
