Sharp Wave-ripple Complexes
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Sharp Wave-ripple Complexes
Sharp waves and ripples (SPW-R), also called sharp wave ripples (SWR), are oscillatory patterns produced by extremely synchronized activity of neurons in the mammalian hippocampus and neighboring regions which occur spontaneously in idle waking states or during NREM sleep. They can be observed with a variety of electrophysiological methods such as Electrophysiology, field recordings or Electroencephalography, EEG. They are composed of large amplitude sharp waves in local field potential and produced by thousands of neurons firing together within a 30–100 ms window. Within this broad time window, Pyramidal cell, pyramidal cells fire only at specific times set by fast spiking GABAergic interneurons. The fast rhythm of inhibition (150-200 Hz) synchronizes the firing of active pyramidal cells, each of which only fires one or two Action potential, action potentials exactly between the inhibitory peaks, collectively generating the ripple pattern. SWRs have been extensively characterized ...
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Sharp Wave Ripple
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