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Second Generation Multiplex Plus
Second Generation Multiplex Plus (SGM Plus), is a DNA profiling system developed by Applied Biosystems. It is an updated version of Second Generation Multiplex. SGM Plus has been used by the UK National DNA Database since 1998. An SGM Plus profile consists of a list of 10 number pairs, one number pair for each of 10 genetic markers, along with two letters (XX or XY) which show the result of the Amelogenin sex indicating test. Each number pair denotes the two allele values for the marker - one value is inherited from each of the subject's parents. If both alleles are the same, then only a single number, rather than a pair, is recorded. Genetic markers The genetic markers (or loci) used by SGM Plus are all short tandem repeats (STRs). The markers used are: VWA, D8S1179, D21S11, D18S51, TH01, FGA, D3S1358, D16S539, D2S1338 and D19S433. Where a marker's designation begins with D, the digits immediately following the D indicate the chromosome that contains the marker. For example, D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Profiling
DNA profiling (also called DNA fingerprinting and genetic fingerprinting) is the process of determining an individual's deoxyribonucleic acid (DNA) characteristics. DNA analysis intended to identify a species, rather than an individual, is called DNA barcoding. DNA profiling is a forensic technique in criminal investigations, comparing criminal suspects' profiles to DNA evidence so as to assess the likelihood of their involvement in the crime. It is also used in paternity testing, to establish immigration eligibility, and in genealogical and medical research. DNA profiling has also been used in the study of animal and plant populations in the fields of zoology, botany, and agriculture. Background Starting in the mid 1970s, scientific advances allowed the use of DNA as a material for the identification of an individual. The first patent covering the direct use of DNA variation for forensicsUS5593832A was filed by Jeffrey Glassberg in 1983, based upon work he had done while ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Standards And Technology
The National Institute of Standards and Technology (NIST) is an agency of the United States Department of Commerce whose mission is to promote American innovation and industrial competitiveness. NIST's activities are organized into Outline of physical science, physical science laboratory programs that include Nanotechnology, nanoscale science and technology, engineering, information technology, neutron research, material measurement, and physical measurement. From 1901 to 1988, the agency was named the National Bureau of Standards. History Background The Articles of Confederation, ratified by the colonies in 1781, provided: The United States in Congress assembled shall also have the sole and exclusive right and power of regulating the alloy and value of coin struck by their own authority, or by that of the respective states—fixing the standards of weights and measures throughout the United States. Article 1, section 8, of the Constitution of the United States, ratified i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Population Genetics In The United Kingdom
Population is a set of humans or other organisms in a given region or area. Governments conduct a census to quantify the resident population size within a given jurisdiction. The term is also applied to non-human animals, microorganisms, and plants, and has specific uses within such fields as ecology and genetics. Etymology The word ''population'' is derived from the Late Latin ''populatio'' (a people, a multitude), which itself is derived from the Latin word ''populus'' (a people). Use of the term Social sciences In sociology and population geography, population refers to a group of human beings with some predefined feature in common, such as location, race, ethnicity, nationality, or religion. Ecology In ecology, a population is a group of organisms of the same species which inhabit the same geographical area and are capable of interbreeding. The area of a sexual population is the area where interbreeding is possible between any opposite-sex pair within the area ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Law Enforcement In The United Kingdom
Law enforcement in the United Kingdom is organised separately in each of the legal systems of the United Kingdom: England and Wales, Scotland, and Northern Ireland. Most law enforcement duties are carried out by police, police constables of a territorial police force. As of 2021, there were 39 territorial police forces in England, 4 in Wales, Police Scotland, one in Scotland, and Police Service of Northern Ireland, one in Northern Ireland. Each is responsible for most law enforcement and crime reduction in its police area. The territorial police forces of England and Wales are overseen by the Home Office and by a police and crime commissioner or other police authority, although they are operationally independent from government. The British Transport Police (BTP), the Ministry of Defence Police (MDP), and the Civil Nuclear Constabulary (CNC) provide Special police, specialist policing services in England, Scotland and Wales. The National Crime Agency (NCA) is primarily tasked ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Identity Documents Of The United Kingdom
Identity may refer to: * Identity document * Identity (philosophy) * Identity (social science) * Identity (mathematics) Arts and entertainment Film and television * ''Identity'' (1987 film), an Iranian film * ''Identity'' (2003 film), an American mystery psychological thriller film * ''Identity'' (2025 film), a Malayalam action-thriller film * ''Identity'' (game show), an American game show * ''Identity'' (TV series), a British police procedural drama television series * "Identity" (''Arrow''), a 2013 episode * "Identity" (''Burn Notice''), a 2007 episode * "Identity" (''Charlie Jade''), a 2005 episode * "Identity" (''Legend of the Seeker''), a 2008 episode * "Identity" (''Law & Order: Special Victims Unit'' episode), a 2005 episode * "Identity" (''NCIS: Los Angeles''), a 2009 pilot episode * "Identity" (''Stewart Lee's Comedy Vehicle''), a 2011 episode Music Albums * ''Identity'' (3T album), 2004 * ''Identity'' (BoA album), 2010 * ''Identity'' (Far E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Profiling Techniques
Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a Nucleic acid double helix, double helix. The polymer carries genetics, genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life. The two DNA strands are known as polynucleotides as they are composed of simpler monomeric units called nucleotides. Each nucleotide is composed of one of four nitrogenous base, nitrogen-containing nucleobases (cytosine [C], guanine [G], adenine [A] or thymine [T]), a monosaccharide, sugar called deoxyribose, and a Organophosphate, phosphate group. The nucleotides are joined to one another in a chain by covalent bonds (known as the Phosphod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biometrics
Biometrics are body measurements and calculations related to human characteristics and features. Biometric authentication (or realistic authentication) is used in computer science as a form of identification and access control. It is also used to identify individuals in groups that are under surveillance. Biometric identifiers are the distinctive, measurable characteristics used to label and describe individuals. Biometric identifiers are often categorized as physiological characteristics which are related to the shape of the body. Examples include, but are not limited to fingerprint, palm veins, face recognition, DNA, palm print, hand geometry, iris recognition, retina, odor/scent, voice, shape of ears and gait. Behavioral characteristics are related to the pattern of behavior of a person, including but not limited to mouse movement, typing rhythm, gait, signature, voice, and behavioral profiling. Some researchers have coined the term behaviometrics (behavioral biom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Applied Genetics
Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinant DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40 with the lambda virus. As well as inserting genes, the process can be used to remove, or "knock out", genes. The new DNA can either be inserted randomly or targeted to a specific part of the genome. An organism that is generated through genetic engineering is considered to be genetically modified ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National DNA Database
A DNA database or DNA databank is a database of DNA profiling, DNA profiles which can be used in the analysis of genetic diseases, genetic fingerprinting for criminology, or genetic genealogy. DNA databases may be public or private, the largest ones being national DNA databases. DNA databases are often employed in Forensic science, forensic investigations. When a match is made from a national DNA database to link a crime scene to a person whose DNA profile is stored on a database, that link is often referred to as a ''cold hit''. A cold hit is of particular value in linking a specific person to a crime scene, but is of less evidential value than a DNA match made without the use of a DNA database. Research shows that DNA databases of criminal offenders reduce crime rates. Types Forensic A forensic database is a centralized DNA database for storing DNA profiles of individuals that enables searching and comparing of DNA samples collected from a crime scene against stored profiles. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crown Prosecution Service
The Crown Prosecution Service (CPS) is the principal public agency for conducting criminal prosecutions in England and Wales. It is headed by the Director of Public Prosecutions. The main responsibilities of the CPS are to provide legal advice to the police and other investigative agencies during the course of criminal investigations, to decide whether a suspect should face criminal charges following an investigation, and to conduct prosecutions both in the magistrates' courts and the Crown Court. The Attorney General for England and Wales superintends the CPS's work and answers for it in Parliament, although the Attorney General has no influence over the conduct of prosecutions, except when national security is an issue or for a small number of offences that require the Attorney General's permission to prosecute. History Historically prosecutions were conducted through a patchwork of different systems. For serious crimes tried at the county level, justices of the peace o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genetics Commission
The Human Genetics Commission (HGC) was an advisory non-departmental public body that advised the UK government on the ethical and social aspects of genetics. This included genetic testing, cloning and other aspects of molecular medicine. The Commission was created after a review of the UK government biotechnology advisory framework in 1999. It was chaired initially by the lawyer, Baroness Helena Kennedy QC and, from 2007 to 2009, the acting chair was Sir John Sulston. From 2009, the Commission was chaired by Professor Jonathan Montgomery and comprised 21 members whose backgrounds include the law, medicine, consumer affairs, philosophy and ethics, scientific research, and clinical practice. Representatives of the Chief Medical Officers of England, Scotland, Wales, and Northern Ireland Northern Ireland ( ; ) is a Countries of the United Kingdom, part of the United Kingdom in the north-east of the island of Ireland. It has been #Descriptions, variously described as a country ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tandem Repeat
In genetics, tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other, e.g. ATTCG ATTCG ATTCG, in which the sequence ATTCG is repeated three times. Several protein domains also form tandem repeats within their amino acid primary structure, such as armadillo repeats. However, in proteins, perfect tandem repeats are rare in naturally proteins, but they have been added to designed proteins. Tandem repeats constitute about 8% of the human genome. They are implicated in more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington's disease, and several cancers. Terminology All tandem repeat arrays are classifiable as satellite DNA, a name originating from the fact that tandem DNA repeats, by nature of repeating the same nucleotide sequences repeatedly, have a unique ratio of the two possible nucleotide base pair combinations, conferring them a specific mass density that a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
