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Sean F. Scott
Sean Forrester Scott (May 20, 1969 – February 9, 2009) was a self-educated disease activist and researcher, filmmaker, innovator, entrepreneur and until the time of his death, the president of the ALS Therapy Development Institute, the world's largest amyotrophic lateral sclerosis research center. Scott himself was diagnosed with ALS in 2008 at the age of 38. Activism Scott became active with ALS TDI when his mother, Vanna, was diagnosed with ALS in 2001. Four more of Vanna's seven siblings succumbed to the familial form of the disease by 2007, and eventually Sean Scott too died of complications from ALS in 2009. In 2008, Scott was lead author of a landmark publication in the journal, Amyotrophic Lateral Sclerosis that described guidelines for experimental design of studies evaluating therapeutics in the mouse model. The work identified crucial errors present in many existing preclinical ALS studies. Scott's effort to establish standard model guidelines for preclinical dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ALS Therapy Development Institute
The ALS Therapy Development Institute (ALS TDI) is a non-profit biotechnology research organization focused on finding treatments for amyotrophic lateral sclerosis (ALS). With a staff including more than 30 scientists, it operates a research and development program centered on ALS. History ALS TDI was founded as the ALS Therapy Development Foundation (ALS TDF) in 1999 by James Heywood, Robert Bonazoli, and Melinda Marsh Heywood after James' brother, Stephen Heywood, was diagnosed with the disease. Dr. Tennore Ramesh joined ALS-TDF when his sister in law was diagnosed with ALS and setup the research facility and served as Chief Scientific Officer from inception until 2003. The organization was initially funded through a donation from Stephen, as well as one from Alex and Brit d'Arbeloff. The Foundation's first therapy concept was to replace EAAT2 protein using gene therapy. In 2004, the Foundation moved to a location in Cambridge, Massachusetts with an in-house lab. ALS TDF con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Francisco, California
San Francisco, officially the City and County of San Francisco, is a commercial, Financial District, San Francisco, financial, and Culture of San Francisco, cultural center of Northern California. With a population of 827,526 residents as of 2024, San Francisco is the List of California cities by population, fourth-most populous city in the U.S. state of California and the List of United States cities by population, 17th-most populous in the United States. San Francisco has a land area of at the upper end of the San Francisco Peninsula and is the County statistics of the United States, fifth-most densely populated U.S. county. Among U.S. cities proper with over 250,000 residents, San Francisco is ranked first by per capita income and sixth by aggregate income as of 2023. San Francisco anchors the Metropolitan statistical area#United States, 13th-most populous metropolitan statistical area in the U.S., with almost 4.6 million residents in 2023. The larger San Francisco Bay Area ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Berkeley
The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after the Anglo-Irish philosopher George Berkeley, it is the state's first land-grant university and is the founding campus of the University of California system. Berkeley has an enrollment of more than 45,000 students. The university is organized around fifteen schools of study on the same campus, including the UC Berkeley College of Chemistry, College of Chemistry, the UC Berkeley College of Engineering, College of Engineering, UC Berkeley College of Letters and Science, College of Letters and Science, and the Haas School of Business. It is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". Lawrence Berkeley National Laboratory was originally founded as par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ALS TDI
The ALS Therapy Development Institute (ALS TDI) is a non-profit biotechnology research organization focused on finding treatments for amyotrophic lateral sclerosis (ALS). With a staff including more than 30 scientists, it operates a research and development program centered on ALS. History ALS TDI was founded as the ALS Therapy Development Foundation (ALS TDF) in 1999 by James Heywood, Robert Bonazoli, and Melinda Marsh Heywood after James' brother, Stephen Heywood, was diagnosed with the disease. Dr. Tennore Ramesh joined ALS-TDF when his sister in law was diagnosed with ALS and setup the research facility and served as Chief Scientific Officer from inception until 2003. The organization was initially funded through a donation from Stephen, as well as one from Alex and Brit d'Arbeloff. The Foundation's first therapy concept was to replace EAAT2 protein using gene therapy. In 2004, the Foundation moved to a location in Cambridge, Massachusetts with an in-house lab. ALS TDF con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward W
Edward is an English language, English male name. It is derived from the Old English, Anglo-Saxon name ''Ēadweard'', composed of the elements ''wikt:ead#Old English, ēad'' "wealth, fortunate; prosperous" and ''wikt:weard#Old English, weard'' "guardian, protector”. History The name Edward was very popular in Anglo-Saxon England, but the rule of the House of Normandy, Norman and House of Plantagenet, Plantagenet dynasties had effectively ended its use amongst the upper classes. The popularity of the name was revived when Henry III of England, Henry III named his firstborn son, the future Edward I of England, Edward I, as part of his efforts to promote a cult around Edward the Confessor, for whom Henry had a deep admiration. Variant forms The name has been adopted in the Iberian Peninsula#Modern Iberia, Iberian peninsula since the 15th century, due to Edward, King of Portugal, whose mother was English. The Spanish/Portuguese forms of the name are Eduardo and Duarte (name), Duart ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or—in the United States—Lou Gehrig's disease (LGD), is a rare, Terminal illness, terminal neurodegenerative disease, neurodegenerative disorder that results in the progressive loss of both upper and lower motor neurons that normally control Skeletal muscle, voluntary muscle contraction. ALS is the most common form of the motor neuron diseases. ALS often presents in its early stages with gradual muscle Spasticity, stiffness, Fasciculation, twitches, Muscle weakness, weakness, and Muscle atrophy, wasting. Motor neuron loss typically continues until the abilities to eat, speak, move, and, lastly, breathe are all lost. While only 15% of people with ALS also fully develop frontotemporal dementia, an estimated 50% face at least some minor difficulties with cognitive disorder, thinking and behavior. Depending on which of the aforementioned symptoms develops first, ALS is classified as ''limb-onset'' (b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features Peer review, peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2022 ''Journal Citation Reports'' (with an ascribed impact factor of 50.5), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in the autumn of 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander MacMillan (publisher), Alexander MacMillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Augie Nieto
Augustine L. Nieto II (February 15, 1958 – February 22, 2023) was the founder and chief executive of Life Fitness, as well as the chairman of Augie's Quest to Cure ALS, and the ALS Therapy Development Institute. He and his wife, Lynne, lived in Corona Del Mar, California, and had four children and eight grandchildren. He was diagnosed with amyotrophic lateral sclerosis (ALS) disease in 2005, and established "Augie's Quest to Cure ALS", which has raised over $75 million in funds for research into the disease. A documentary titled, "Augie" was released in 2017. Advances in technological communication using brain wave detection in patients with physical challenges that impacted their ability to speak was mentioned in Through the Wormhole, with Morgan Freeman Season 4, Episode 6 in 2013. Augie Nieto's involvement in helping scientists improve the technology was featured in this episode. Career In 1977, Nieto founded Lifecycle with an exercise bike of the same name. In 1984, he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscular Dystrophy Association
Muscular Dystrophy Association (MDA) is an American nonprofit organization dedicated to supporting people living with muscular dystrophy, ALS, and related Neuromuscular disease, neuromuscular diseases. Founded in 1950 by Paul Cohen, who lived with Facioscapulohumeral muscular dystrophy (FSHD), MDA accelerates research, advances care, and works to empower families to live longer and more independent lives but is also perhaps known for its working relationship with comedian, entertainer and actor Jerry Lewis, its national chairman of 55 years and his annual Labor Day The Jerry Lewis MDA Labor Day Telethon, telethon, which he hosted live from 1966 until 2010 each year. The organization's headquarters is in Chicago, Illinois. History The organization was founded in 1950 by a group with personal connections to muscular dystrophy, including Paul Cohen who lived with Facioscapulohumeral muscular dystrophy (FSHD). Originally known as the Muscular Dystrophy Associations of America, it w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1969 Births
1969 (Roman numerals, MCMLXIX) was a common year starting on Wednesday of the Gregorian calendar, the 1969th year of the Common Era (CE) and ''Anno Domini'' (AD) designations, the 969th year of the 2nd millennium, the 69th year of the 20th century, and the 10th and last year of the 1960s decade. Events January * January 4 – The Government of Spain hands over Ifni to Morocco. * January 5 – Ariana Afghan Airlines Flight 701 crashes into a house on its approach to London's Gatwick Airport, killing 50 of the 62 people on board and two of the home's occupants. * January 14 – USS Enterprise fire, An explosion aboard the aircraft carrier USS Enterprise (CVN-65), USS ''Enterprise'' near Hawaii kills 28 and injures 314. * January 16 – First successful docking of two crewed spacecraft in orbit and the first transfer of crew from one space vehicle to another (by a space walk) between Soviet craft Soyuz 5 and Soyuz 4. * January 18 – Failure of Soyuz 5's service module to separ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2009 Deaths
This is a list of lists of deaths of notable people, organized by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked below. 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Earlier years ''Deaths in years earlier than this can usually be found in the main articles of the years.'' See also * Lists of deaths by day * Deaths by year (category) {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deaths From Motor Neuron Disease In California
Death is the end of life; the irreversible cessation of all biological functions that sustain a living organism. Death eventually and inevitably occurs in all organisms. The remains of a former organism normally begin to decompose shortly after death. Some organisms, such as '' Turritopsis dohrnii'', are biologically immortal; however, they can still die from means other than aging. Death is generally applied to whole organisms; the equivalent for individual components of an organism, such as cells or tissues, is necrosis. Something that is not considered an organism, such as a virus, can be physically destroyed but is not said ''to die'', as a virus is not considered alive in the first place. As of the early 21st century, 56 million people die per year. The most common reason is aging, followed by cardiovascular disease, which is a disease that affects the heart or blood vessels. As of 2022, an estimated total of almost 110 billion humans have died, or roughly 94% of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
