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Scyllo-Inositol
''scyllo''-Inositol is one of the stereoisomers of inositol. It is also known as scyllitol, cocositol, quercinitol, and 1,3,5/2,4,6-hexahydroxycyclohexane. ''scyllo''-Inositol is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm. Biological effects Researchers at the University of Toronto have found that ''scyllo''-inositol can block the development of amyloid-beta (Aβ) plaques in the brains of transgenic mice. ''scyllo''-Inositol also reversed memory deficits, reduced the formation of Aβ plaques, and alleviated other symptoms that are associated with the accumulation of Aβ proteins in these mice. Researchers at the Harvard Medical School-affiliated McLean Hospital identified that chronic users of anabolic steroids had statistically significantly lower levels of brain scyllo-inositol levels as compared to non-users. Clinical evaluation ''scyllo''-Inositol is under investigation by Transition Therapeutics as a disease-modifying therapy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inositol
Inositol, or more precisely ''myo''-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors and participates in osmoregulation. It is a sugar alcohol with half the sweetness of sucrose (table sugar). It is made naturally in the human body from glucose. A human kidney makes about two grams per day. Other tissues synthesize it too, and the highest concentration is in the brain, where it plays an important role by making other neurotransmitters and some steroid hormones bind to their receptors. Inositol is promoted as a dietary supplement in the management of polycystic ovary syndrome ( PCOS). However, there is only evidence of very low quality for its efficacy in increasing fertility for IVF in women with PCOS. Overview ''myo''-Inositol plays an important role as the structural basis for a number of secondary messengers in euka ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Union Of Pure And Applied Chemistry
The International Union of Pure and Applied Chemistry (IUPAC ) is an international federation of National Adhering Organizations working for the advancement of the chemical sciences, especially by developing nomenclature and terminology. It is a member of the International Science Council (ISC). IUPAC is registered in Zürich, Switzerland, and the administrative office, known as the "IUPAC Secretariat", is in Research Triangle Park, North Carolina, United States. This administrative office is headed by IUPAC's executive director, currently Lynn Soby. IUPAC was established in 1919 as the successor of the International Congress of Applied Chemistry for the advancement of chemistry. Its members, the National Adhering Organizations, can be national chemistry societies, national academies of sciences, or other bodies representing chemists. There are fifty-four National Adhering Organizations and three Associate National Adhering Organizations. IUPAC's Inter-divisional Committee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FDA Fast Track Development Program
Fast track is a designation by the United States Food and Drug Administration (FDA) of an investigational drug for expedited review to facilitate development of drugs that treat a serious or life-threatening condition and fill an unmet medical need. Fast Track designation must be requested by the drug company. The request can be initiated at any time during the drug development process. FDA will review the request and attempt to make a decision within sixty days. Purpose Fast Track is one of five Food and Drug Administration (FDA) approaches to make new drugs available as rapidly as possible: the others are priority review, breakthrough therapy, accelerated approval The United States Food and Drug Administration (FDA) initiated the FDA Accelerated Approval Program in 1992 to allow faster approval of drugs for serious conditions that fill an unmet medical need. The faster approval relies on use of surrogate en ... and Regenerative Medicine Advanced Therapy. Fast Track was in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-chiro-Inositol
1L-''chiro''-Inositol (L-''chiro''-Inositol) is one of the isomers of inositol Inositol, or more precisely ''myo''-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors an .... See also * ''allo''-Inositol * ''cis''-Inositol * 1D-''chiro''-Inositol * ''epi''-Inositol * ''muco''-Inositol * ''neo''-Inositol * ''scyllo''-Inositol References Inositol {{alcohol-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epi-Inositol
''Epi''-Inositol is one of the stereoisomers of inositol. Use in medicine Epi-inositol has been found to regulate Yeast Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom. The first yeast originated hundreds of millions of years ago, and at least 1,500 species are currently recognized. They are estimated to consti ... INO1 Gene Encoding ( Inositol-1-P synthase) in animals. During the study with Epi-Inositol, Yeast INO1-expression was measured in northern blots. See also * ''allo''-Inositol * ''cis''-Inositol * D-''chiro''-Inositol * L-''chiro''-Inositol * ''muco''-Inositol * ''neo''-Inositol * ''scyllo''-Inositol References Inositol {{alcohol-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
D-chiro-Inositol
1D-''chiro''-Inositol (formerly D-''chiro''-inositol, commonly abbreviated DCI) is a member of a family of related substances often referred to collectively as "inositol", although that term encompasses several isomers of questionable biological relevance, including 1L-''chiro''-inositol. ''myo''-Inositol is converted into DCI by an insulin dependent NAD/NADH epimerase enzyme. It is known to be an important secondary messenger in insulin signal transduction Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular .... DCI accelerates the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, rate limiting enzymes of non-oxidative and oxidative glucose disposal. DCI may act to bypass defective normal epimerization of ''myo''-inositol to DCI associated with insulin resistance and a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allo-Inositol
''allo''-Inositol is a stereoisomer of inositol Inositol, or more precisely ''myo''-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors an .... See also * ''cis''-Inositol * D-''chiro''-Inositol * L-''chiro''-Inositol * ''epi''-Inositol * ''muco''-Inositol * ''neo''-Inositol * ''scyllo''-Inositol References Inositol {{alcohol-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elan Corporation
Elan or Élan may refer to: People *Elan Atias (born 1975), American singer-songwriter *Elán (musician) (born 1983), Mexican singer * Poets of Elan, a group of Ecuadorian poets Fictional characters * Elan (Order of the Stick), a character in the webcomic ''The Order of the Stick'' * Elan (Dungeons & Dragons), a fictional race in ''Dungeons & Dragons'' * Elan (Star Wars Legends), a ''Star Wars'' character Places * Élan, Ardennes, a commune of the Ardennes ''département'' in France *Elan Valley, a valley in Wales *Afon Elan, a river in Wales * Elan (Prut), a river in eastern Romania * Élan School, a private boarding school in Poland, Maine * Elan, Bichursky District, Republic of Buryatia Companies *Elan (company), a Slovenian sports equipment company *Élan, a pharmaceutical company based in Athlone, County Roscommon, Ireland *Élan Motorsport Technologies, a race car manufacturing consortium based in the United States * ELAN Microelectronics Corp., a Taiwanese manufacturer o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Royal Institute of Chemistry, the Faraday Society, and the Society for Analytical Chemistry with a new Royal Charter and the dual role of learned society and professional body. At its inception, the Society had a combined membership of 34,000 in the UK and a further 8,000 abroad. The headquarters of the Society are at Burlington House, Piccadilly, London. It also has offices in Thomas Graham House in Cambridge (named after Thomas Graham (chemist), Thomas Graham, the first president of the Chemical Society) where ''RSC Publishing'' is based. The Society has offices in the United States, on the campuses of The University of Pennsylvania and Drexel University, at the University City Science Center in Philadelphia, Pennsylvania, in both Beijing a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
