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Santa Cruz Biotechnology
Santa Cruz Biotechnology is a developer of biological products for medical research, and is one of the world’s largest suppliers of antibodies. The company was founded in 1991 by Dr. John Stephenson and his wife Brenda Stephenson in Santa Cruz, California. Santa Cruz Biotechnology headquarters are located in Dallas, Texas, with additional US facilities in Paso Robles, California, and Sun Valley, Idaho. The company also has international locations in Germany, Shanghai and Canada. History The company was originally headquartered in Santa Cruz, California, and began offering antibodies to the research community. Other products lines were added over the years – siRNAs in 2007, shRNAs in 2009, and laboratory supplies in 2010. In 2010, the offering of biochemical was expanded from just a few hundred to over 100,000 different products. Products related to CRISPR were introduced in 2015 for over 37,000 mouse and human genes In biology, the word gene (from , ; "...Wilhelm Jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research
Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from " basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientific principles that may apply to a ''preclinical'' understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine. Both clinical and preclinical research phases exist in the pharmaceutical industry's drug development pipelines, where the clinical phase is denoted by the term ''clinical trial''. However, only part of the clinical or preclinical research is oriented towards a specific pharmaceutical purpose. The need for fundamental and mechanism-based understanding, diagnostics, medical devices, and non-pharmaceutical therapies means that pharmaceutical res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bloomberg News
Bloomberg News (originally Bloomberg Business News) is an international news agency headquartered in New York City and a division of Bloomberg L.P. Content produced by Bloomberg News is disseminated through Bloomberg Terminals, Bloomberg Television, Bloomberg Radio, ''Bloomberg Businessweek'', ''Bloomberg Markets'', Bloomberg.com, and Bloomberg's mobile platforms. Since 2015, John Micklethwait has served as editor-in-chief. History Bloomberg News was founded by Michael Bloomberg and Matthew Winkler in 1990 to deliver financial news reporting to Bloomberg Terminal subscribers. The agency was established in 1990 with a team of six people. Winkler was first editor-in-chief. In 2010, Bloomberg News included more than 2,300 editors and reporters in 72 countries and 146 news bureaus worldwide. Beginnings (1990–1995) Bloomberg Business News was created to expand the services offered through the terminals. According to Matthew Winkler, then a writer for ''The Wall Street Journal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibodies
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santa Cruz, California
Santa Cruz ( Spanish for "Holy Cross") is the county seat and largest city of Santa Cruz County, in Northern California. As of the 2020 census, the city population was 62,956. Situated on the northern edge of Monterey Bay, Santa Cruz is a popular tourist destination, owing to its beaches, surf culture, and historic landmarks. Santa Cruz was founded by the Spanish in 1791, when Fermín de Lasuén established Mission Santa Cruz. Soon after, a settlement grew up near the mission called Branciforte, which came to be known across Alta California for its lawlessness. With the Mexican secularization of the Californian missions in 1833, the former mission was divided and granted as rancho grants. Following the American Conquest of California, Santa Cruz eventually incorporated as a city in 1866. The creation of the Santa Cruz Beach Boardwalk in 1907 solidified the city's status as a seaside resort community, while the establishment of the University of California, Santa Cruz in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dallas
Dallas () is the List of municipalities in Texas, third largest city in Texas and the largest city in the Dallas–Fort Worth metroplex, the List of metropolitan statistical areas, fourth-largest metropolitan area in the United States at 7.5 million people. It is the largest city in and County seat, seat of Dallas County, Texas, Dallas County with portions extending into Collin County, Texas, Collin, Denton County, Texas, Denton, Kaufman County, Texas, Kaufman and Rockwall County, Texas, Rockwall counties. With a 2020 United States census, 2020 census population of 1,304,379, it is the List of United States cities by population, ninth most-populous city in the U.S. and the List of cities in Texas by population, third-largest in Texas after Houston and San Antonio. Located in the North Texas region, the city of Dallas is the main core of the largest metropolitan area in the Southern United States and the largest inland metropolitan area in the U.S. that lacks any navigable link ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paso Robles, California
Paso Robles ( ), officially El Paso de Robles ( Spanish for "The Pass of Oaks"), is a city in San Luis Obispo County, California, United States. Located on the Salinas River approximately north of San Luis Obispo, the city is known for its hot springs, its abundance of wineries, its production of olive oil, almond orchards, and for playing host to the California Mid-State Fair. Etymology and pronunciation The city's full name is "El Paso de Robles", which in Spanish means "The Pass of the Oaks". People differ on the pronunciation of the city's shortened name of "Paso Robles". While its Spanish pronunciation is , residents anglicize the pronunciation as . This anglicized version has been used in the city phone message. History This area of the Central Coast, known as the City of El Paso De Robles, Paso Robles, or simply "Paso", is known for its thermal springs. Native Americans known as the Salinan lived in the area thousands of years before the mission era. They kn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sun Valley, Idaho
Sun Valley is a resort city in the western United States, in Blaine County, Idaho, adjacent to the city of Ketchum in the Wood River valley. The population was 1406 at the 2010 census, down from 1427 in 2000.Spokesman-Review – 2010 census – Sun Valley, Idaho; accessed January 7, 2012 The elevation of Sun Valley (at the Lodge) is . Among skiers, the term "Sun Valley" refers to the alpine ski area, which consists of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shanghai
Shanghai (; , , Standard Mandarin pronunciation: ) is one of the four direct-administered municipalities of the People's Republic of China (PRC). The city is located on the southern estuary of the Yangtze River, with the Huangpu River flowing through it. With a population of 24.89 million as of 2021, Shanghai is the most populous urban area in China with 39,300,000 inhabitants living in the Shanghai metropolitan area, the second most populous city proper in the world (after Chongqing) and the only city in East Asia with a GDP greater than its corresponding capital. Shanghai ranks second among the administrative divisions of Mainland China in human development index (after Beijing). As of 2018, the Greater Shanghai metropolitan area was estimated to produce a gross metropolitan product ( nominal) of nearly 9.1 trillion RMB ($1.33 trillion), exceeding that of Mexico with GDP of $1.22 trillion, the 15th largest in the world. Shanghai is one of the world's major centers fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Interfering RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20-24 (normally 21) base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. Text was copied from this source, which is available under Creative Commons Attribution 4.0 International License Structure Naturally occurring siRNAs have a well-defined structure that is a short (usually 20 to 24- bp) double-stranded RNA (dsRNA) with phosphorylated 5' ends and hydroxylated 3' ends with two overhanging nucleotides. The Dicer enzyme catalyzes production of siRNAs from long dsRNAs and small hairpin RNAs. siRNAs can also be introduced into cells by transfection. Since in principle any gene can be knocked down by a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Short Hairpin RNA
A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi). Gene expression, Expression of shRNA in cells is typically accomplished by delivery of plasmids or through viral or bacterial Vector (molecular biology), vectors. shRNA is an advantageous mediator of RNAi in that it has a relatively low rate of degradation and turnover. However, it requires use of an expression vector, which has the potential to cause side effects in medicinal applications. The Promoter (genetics), promoter choice is essential to achieve robust shRNA expression. At first, RNA polymerase III, polymerase III promoters such as U6 and H1 were used; however, these promoters lack spatial and temporal control. As such, there has been a shift to using RNA polymerase II, polymerase II promoters, which are inducible, to regulate shRNA expression. Delivery Expression of shRNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRISPR
CRISPR () (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti-phage) defense system of prokaryotes and provide a form of acquired immunity. CRISPR is found in approximately 50% of sequenced bacterial genomes and nearly 90% of sequenced archaea. Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and cleave specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR-Cas9 that can be used to edit genes within organisms. This ed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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