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Sanford Rosenthal
Sanford Morris Rosenthal (May 5, 1897 – May 1, 1989) was born in Albany, Georgia. Early life and career He received a medical degree at Vanderbilt University in 1920, and completed a residency and internship at Boston City Hospital (1921–1922). However, his interests shifted to medical research when he became a Fellow of the National Research Council in a pharmacology lab at Johns Hopkins University (1922–1925). He worked in the Department of Pharmacology at McGill University in Montreal, Canada from 1925-1927. Finally, in 1928, he joined the United States Public Health Service (USPHS) in Washington, D.C. Dr. Rosenthal was Chief of the Laboratory of Pharmacology and Toxicology at the National Institute of Arthritis and Metabolic Diseases (NIAMD) for 13 years before retiring in 1961. He attained the rank of Medical Director in the USPHS Commissioned Officer Corps. After retiring, Dr. Rosenthal continued to do research at the NIAMD for almost 20 years. He was an author on ov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albany, Georgia
Albany ( ) is a city in the U.S. state of Georgia. Located on the Flint River, it is the seat of Dougherty County, and is the sole incorporated city in that county. Located in southwest Georgia, it is the principal city of the Albany, Georgia metropolitan area. The population was 77,434 at the 2010 U.S. Census, making it the eighth-largest city in the state. It became prominent in the nineteenth century as a shipping and market center, first served by riverboats. Scheduled steamboats connected Albany with the busy port of Apalachicola, Florida. They were replaced by railroads. Seven lines met in Albany, and it was a center of trade in the Southeast. It is part of the Black Belt, the extensive area in the Deep South of cotton plantations. From the mid-20th century, it received military investment during World War II and after, that helped develop the region. Albany and this area were prominent during the civil rights era, particularly during the early 1960s as activists worked ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Public Health Service Commissioned Corps
The United States Public Health Service Commissioned Corps (PHSCC), also referred to as the Commissioned Corps of the United States Public Health Service, is the federal uniformed service of the U.S. Public Health Service (PHS) and one of the eight uniformed services of the United States. The commissioned corps' primary mission is the protection, promotion, and advancement of health and safety of the general public. Along with the NOAA Commissioned Officer Corps, the Public Health Service Commissioned Corps is one of two uniformed services that consist only of commissioned officers and has no enlisted or warrant officer ranks, although warrant officers have been authorized for use within the service. Officers of the commissioned corps are classified as noncombatants, unless directed to serve as part of the military by the president or detailed to a service branch of the military. Members of the commissioned corps wear uniforms modeled after the United States Navy and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spermidine
Spermidine is a polyamine compound () found in ribosomes and living tissues and having various metabolic functions within organisms. It was originally isolated from semen. Function Spermidine is an aliphatic polyamine. Spermidine synthase (SPDS) catalyzes its formation from putrescine. It is a precursor to other polyamines, such as spermine and its structural isomer thermospermine. Spermidine synchronizes an array of biological processes, (such as Ca2+, Na+, K+ -ATPase) thus maintaining membrane potential and controlling intracellular pH and volume. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-d-aspartate receptor (NMDA receptor), which has been associated with nitric oxide synthase (NOS) and cGMP/PKG pathway activation and a decrease of Na+,K+-ATPase activity in cerebral cortex synaptosomes. Spermidine is a longevity agent in mammals due to various mechanisms of action, which are just beginning to be understood. Autophagy is the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered in 1910, it has been considered a local hormone ( autocoid) because it lacks the classic endocrine glands to secrete it; however, in recent years, histamine has been recognized as a central neurotransmitter. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. It consists of an imidazole ring attached to an ethylamine chain; under physiological conditions, the amino group of the side-chain is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Annals Of The District Of Columbia
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an anc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfanilamide
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to previous wars. Sulfanilamide is rarely if ever used systemically due to toxicity and because more effective sulfonamides are available for this purpose. Modern antibiotics have supplanted sulfanilamide on the battlefield; however, sulfanilamide remains in use today in the form of topical preparations, primarily for treatment of vaginal yeast infections mainly vulvovaginitis which is caused by ''Candida albicans''. The term "sulfanilamides" is also sometimes used to describe a family of molecules containing these functional groups. Examples include: * Furosemide, a loop diuretic * Sulfadiazine, an antibiotic * Sulfamethoxazole, an antibioti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfonamide (medicine)
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Function In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Public Health Reports
''Public Health Reports'' (or ''PHR'') is a peer-reviewed public health journal established in 1878 and published by SAGE Publishing for the Association of Schools and Programs of Public Health and the United States Public Health Service. The title and publication frequency of the journal has varied over the years, but it is currently published bimonthly. The editor-in-chief is Hazel D. Dean. Articles are published under delayed open access, where they become fully open access one year after publication. The articles are available through PubMed Central. History The journal was established in July 1878 as the ''Bulletins of the Public Health'' under the National Quarantine Act of April 29, 1878, issued by the Supervising Surgeon-General at the time, John Maynard Woodworth. This act requested weekly reports of epidemic disease infections to be forwarded to Washington by the American consulates abroad. Publication was suspended after 46 issues on May 24, 1879 as a byproduct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government The federal government of the United States (U.S. federal government or U.S. government) is the national government of the United States, a federal republic located primarily in North America, composed of 50 states, a city within a fede ... responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research fundin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of The American Medical Association
''The Journal of the American Medical Association'' (''JAMA'') is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of biomedicine. The journal was established in 1883 with Nathan Smith Davis as the founding editor. Kirsten Bibbins-Domingo of the University of California San Francisco became the journal editor-in-chief on July 1, 2022, succeeding Howard Bauchner of Boston University. History The journal was established in 1883 by the American Medical Association and superseded the ''Transactions of the American Medical Association''. ''Councilor's Bulletin'' was renamed the ''Bulletin of the American Medical Association'', which later was absorbed by the ''Journal of the American Medical Association''. In 1960, the journal obtained its current title, ''JAMA: The Journal of the American Medical Association''. The journal is commonly referred to as ''JAMA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bromsulphthalein
Bromsulfthalein (also known as bromsulphthalein, bromosulfophthalein, and BSP) is a phthalein dye used in liver function tests. Determining the rate of removal of the dye from the blood stream gives a measure of liver function Liver function tests (LFTs or LFs), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient's liver. These tests include prothrombin time (PT/INR), activated partial thromboplastin tim .... References Triarylmethane dyes Phthalides Bromoarenes Phenols Benzenesulfonates Organic sodium salts {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver Function Tests
Liver function tests (LFTs or LFs), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient's liver. These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin, bilirubin (direct and indirect), and others. The liver transaminases aspartate transaminase (AST or SGOT) and alanine transaminase (ALT or SGPT) are useful biomarkers of liver injury in a patient with some degree of intact liver function. Most liver diseases cause only mild symptoms initially, but these diseases must be detected early. Hepatic (liver) involvement in some diseases can be of crucial importance. This testing is performed on a patient's blood sample. Some tests are associated with functionality (e.g., albumin), some with cellular integrity (e.g., transaminase), and some with conditions linked to the biliary tract ( gamma-glutamyl transferase and alkaline phosphatase). Because some of these tests do no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
