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Sanford Burnham Prebys Medical Discovery Institute
Sanford Burnham Prebys is a nonprofit biomedical research institute located in La Jolla, California. The institute conducts basic research and translational research focused on human disease. Research at the institute focuses on cancer, neurodegeneration, diabetes, infectious diseases, inflammatory diseases, and Pediatrics, pediatric conditions. Additional areas include stem cell research and drug discovery technologies. Sanford Burnham Prebys includes a National Cancer Institute-designated Cancer Center and other specialized programs in genomics, stem cell research, and pediatric health. The institute employs more than 500 scientists, staff, and trainees, and collaborates with academic and industry partners. History Sanford Burnham Prebys originated in 1976 as the La Jolla Cancer Research Foundation, founded by William H. Fishman, Dr. William H. Fishman and Lillian Waterman Fishman after his retirement from Tufts University School of Medicine. The institute was renamed the B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Dollar
The United States dollar (Currency symbol, symbol: Dollar sign, $; ISO 4217, currency code: USD) is the official currency of the United States and International use of the U.S. dollar, several other countries. The Coinage Act of 1792 introduced the U.S. dollar at par with the Spanish dollar, Spanish silver dollar, divided it into 100 cent (currency), cents, and authorized the Mint (facility), minting of coins denominated in dollars and cents. U.S. banknotes are issued in the form of Federal Reserve Notes, popularly called greenbacks due to their predominantly green color. The U.S. dollar was originally defined under a bimetallism, bimetallic standard of (0.7734375 troy ounces) fine silver or, from Coinage Act of 1834, 1834, fine gold, or $20.67 per troy ounce. The Gold Standard Act of 1900 linked the dollar solely to gold. From 1934, its equivalence to gold was revised to $35 per troy ounce. In 1971 all links to gold were repealed. The U.S. dollar became an important intern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William H
William is a masculine given name of Germanic origin. It became popular in England after the Norman conquest in 1066,All Things William"Meaning & Origin of the Name"/ref> and remained so throughout the Middle Ages and into the modern era. It is sometimes abbreviated "Wm." Shortened familiar versions in English include Will or Wil, Wills, Willy, Willie, Bill, Billie, and Billy. A common Irish form is Liam. Scottish diminutives include Wull, Willie or Wullie (as in Oor Wullie). Female forms include Willa, Willemina, Wilma and Wilhelmina. Etymology William is related to the German given name ''Wilhelm''. Both ultimately descend from Proto-Germanic ''*Wiljahelmaz'', with a direct cognate also in the Old Norse name ''Vilhjalmr'' and a West Germanic borrowing into Medieval Latin ''Willelmus''. The Proto-Germanic name is a compound of *''wiljô'' "will, wish, desire" and *''helmaz'' "helm, helmet".Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxfor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurodegenerative Disease
A neurodegenerative disease is caused by the progressive loss of neurons, in the process known as neurodegeneration. Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, tauopathies, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. Because there is no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable; however research has shown that the two major contributing factors to neurodegeneration are oxidative stress and inflammation. Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. These similarities suggest that therap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, San Diego
The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California, United States. Established in 1960 near the pre-existing Scripps Institution of Oceanography in La Jolla, UC San Diego is the southernmost of the ten campuses of the University of California. It offers over 200 undergraduate and graduate degree programs, enrolling 33,096 undergraduate and 9,872 graduate students, with the second largest student housing capacity in the nation. The university occupies near the Pacific coast. UC San Diego consists of 12 undergraduate, graduate, and professional schools as well as 8 undergraduate residential colleges. The university operates 19 organized research units as well as 8 School of Medicine research units, 6 research centers at Scripps Institution of Oceanography, and 2 multi-campus initiatives. UC San Diego is als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salk Institute For Biological Studies
The Salk Institute for Biological Studies is a scientific research institute in the La Jolla community of San Diego, California. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. As of October 2020, the Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer's disease, Parkinson's disease, AIDS, and the neurobiology of American Sign Language. March of Dimes provided the initial funding and continues to support the institute. Research is funded by a variety of public sour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regenerative Medicine
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ transplant rejection via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemogenomics
Chemogenomics, or chemical genomics, is the systematic screening of targeted chemical libraries of small molecules against individual drug target families (e.g., GPCRs, nuclear receptors, kinases, proteases, etc.) with the ultimate goal of identification of novel drugs and drug targets. Typically some members of a target library have been well characterized where both the function has been determined and compounds that modulate the function of those targets (ligands in the case of receptors, inhibitors of enzymes, or blockers of ion channels) have been identified. Other members of the target family may have unknown function with no known ligands and hence are classified as orphan receptors. By identifying screening hits that modulate the activity of the less well characterized members of the target family, the function of these novel targets can be elucidated. Furthermore, the hits for these targets can be used as a starting point for drug discovery. The completion of the hu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerontology
Gerontology ( ) is the study of the social, culture, cultural, psychology, psychological, cognitive, and biology, biological aspects of aging. The word was coined by Ilya Ilyich Mechnikov in 1903, from the Ancient Greek, Greek ('), meaning "old man", and ('), meaning "study of". The field is distinguished from geriatrics, which is the branch of medicine that specializes in the treatment of existing disease in older adults. Gerontologists include researchers and practitioners in the fields of biology, nursing, medicine, criminology, dentistry, social work, physical and occupational therapy, psychology, psychiatry, sociology, economics, political science, architecture, geography, pharmacy, public health, housing, and anthropology. The multidisciplinarity, multidisciplinary nature of gerontology means that there are a number of sub-fields which overlap with gerontology. There are policy issues, for example, involved in government planning and the operation of nursing homes, inve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Disorder
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome. The mutation responsible can occur spontaneously before embryonic development (a ''de novo'' mutation), or it can be inherited from two parents who are carriers of a faulty gene ( autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance). When the genetic disorder is inherited from one or both parents, it is also classified as a hereditary disease. Some disorders are caused by a mutation on the X chromosome and have X-linked inheritance. Very few disorders are inherited on the Y chromosome or mitochondrial DNA (due to their size). There are well over 6,000 known ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conrad Prebys
Conrad Prebys (August 20, 1933 – July 24, 2016) was a property developer and philanthropist based in San Diego, California. Prebys was born on August 20, 1933, in South Bend, Indiana, and graduated from Indiana University. He moved to San Diego in 1965 and co-founded Progress Construction. He bought out his partner in 1980. Over the years, Prebys shifted his focus from construction to property ownership. As of 2015 Prebys' Progress Management owned 81 properties in the greater San Diego area and had an estimated net worth of approximately US$1 billion. The Blackstone Group agreed to purchase the Prebys apartment portfolio in 2021. Prebys owned many apartment buildings, which provided housing for thousands of families with children. His concern for the well-being of these children resulted in his support of local Boys & Girls Clubs, where these children participate in educational and recreational activities and receive guidance from caring adults. In appreciation for his gener ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Services (HHS). Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its scientific research through the NIH Intramural Research Program (IRP) and provides significant biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world, while, as of 2003, the extramural arm provided 28% of biomedical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sioux Falls, South Dakota
Sioux Falls ( ) is the List of cities in South Dakota, most populous city in the U.S. state of South Dakota and the List of United States cities by population, 117th-most populous city in the United States. It is the county seat of Minnehaha County, South Dakota, Minnehaha County and also extends into northern Lincoln County, South Dakota, Lincoln County. The population was 192,517 at the 2020 United States census, 2020 census, and in 2023, its estimated population was 209,289. According to city officials, the estimated population had grown to 219,588 as of early 2025. The Sioux Falls metro area accounts for more than 30% of the state's population. Chartered in 1856 on the banks of the Big Sioux River, the city is situated in the rolling hills at the junction of Interstate 29 in South Dakota, interstates 29 and Interstate 90 in South Dakota, 90. History The history of Sioux Falls revolves around the cascades of the Big Sioux River. The falls were created about 14,000 years ago ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
