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Sandip Kumar Basu
Sandip Kumar Basu (born 1944) is an Indian molecular biologist and the holder of the J. C. Bose Chair of the National Academy of Sciences, India, who is credited with innovations in the treatment protocols of leishmaniasis, tuberculosis, viral infections, multidrug resistant cancer and arterosclerosis. He was honored by the Government of India, in 2001, with the fourth highest Indian honours system, Indian civilian award of Padma Shri. Biography Sandip Kumar Basu was born in Kolkata in the Indian state of West Bengal. He graduated in 1962 from the Presidency College, Calcutta and secured his master's degree in 1964 from the Rajabazar Science College, University College of Science. His doctoral research was at the Calcutta University which he successfully completed in 1968 on the topic, ''regulation of microbial metabolism'' and moved to USA for post doctoral research at Keck School of Medicine of USC, Los Angeles, University of California, Irvine School of Medicine, Public Health ...
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Kolkata
Kolkata (, or , ; also known as Calcutta , List of renamed places in India#West Bengal, the official name until 2001) is the Capital city, capital of the Indian States and union territories of India, state of West Bengal, on the eastern bank of the Hooghly River west of the border with Bangladesh. It is the primary business, commercial, and financial hub of East India, Eastern India and the main port of communication for North-East India. According to the 2011 Indian census, Kolkata is the List of cities in India by population, seventh-most populous city in India, with a population of 45 lakh (4.5 million) residents within the city limits, and a population of over 1.41 crore (14.1 million) residents in the Kolkata metropolitan area, Kolkata Metropolitan Area. It is the List of metropolitan areas in India, third-most populous metropolitan area in India. In 2021, the Kolkata metropolitan area crossed 1.5 crore (15 million) registered voters. The ...
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Public Health Research Institute
The Public Health Research Institute (PHRI) was founded in 1942 by New York City's mayor, Fiorello La Guardia, who appointed David M. Heyman to lead it as an independent not-for-profit research organization. In the late 1980s it was referred to as ''Public Health Research Institute - New York'' In 2002, they moved to Newark, New Jersey. PHRI became part of the New Jersey Medical School in 2006 and since 2013 it has been part at Rutgers University. Their mission is still, as stated in the institute's first annual report, to serve "pressing demands of a large population" as "a vast manufacturing and dignostic enterprise." Dr. Ralph Muckenfuss, director of the Bureau of Laboratories of the Department of Health, was designated as director of the Institute during the war period. History New York City The 1942-founded PHRI was initially housed in the New York City Department of Health's Laboratories; the latter preceded the turn of the nineteenth century. The mission of the Insti ...
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Joseph L
Joseph is a common male given name, derived from the Hebrew Yosef (יוֹסֵף). "Joseph" is used, along with "Josef", mostly in English, French and partially German languages. This spelling is also found as a variant in the languages of the modern-day Nordic countries. In Portuguese and Spanish, the name is "José". In Arabic, including in the Quran, the name is spelled '' Yūsuf''. In Persian, the name is "Yousef". The name has enjoyed significant popularity in its many forms in numerous countries, and ''Joseph'' was one of the two names, along with ''Robert'', to have remained in the top 10 boys' names list in the US from 1925 to 1972. It is especially common in contemporary Israel, as either "Yossi" or "Yossef", and in Italy, where the name "Giuseppe" was the most common male name in the 20th century. In the first century CE, Joseph was the second most popular male name for Palestine Jews. In the Book of Genesis Joseph is Jacob's eleventh son and Rachel's first son, ...
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Michael Stuart Brown
Michael Stuart Brown ForMemRS NAS AAA&S APS (born April 13, 1941) is an American geneticist and Nobel laureate. He was awarded the Nobel Prize in Physiology or Medicine with Joseph L. Goldstein in 1985 for describing the regulation of cholesterol metabolism. Education and early life Brown was born in Brooklyn, New York, the son of Evelyn, a homemaker, and Harvey Brown, a textile salesman. He graduated from Cheltenham High School (Wyncote, Pennsylvania). Brown graduated from the University of Pennsylvania in 1962 and received his M.D. from the University of Pennsylvania School of Medicine in 1966. Career and research Moving to the University of Texas Michael liked vann Warner Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL rec ...
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Low Density Lipoprotein
Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. These groups, from least dense to most dense, are chylomicrons (aka ULDL by the overall density naming convention), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL delivers fat molecules to cells. LDL is involved in atherosclerosis, a process in which it is oxidized within the walls of arteries. Overview Lipoproteins transfer lipids ( fats) around the body in the extracellular fluid, making fats available to body cells for receptor-mediated endocytosis. Lipoproteins are complex particles composed of multiple proteins, typically 80–100 proteins per particle (organized by a single apolipoprotein B for LDL and the larger particles). A single LDL particle is about 220–275 angstroms in diameter, typically transporting 3,000 to 6,000 f ...
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Macrophages
Macrophages (abbreviated as M φ, MΦ or MP) ( el, large eaters, from Greek ''μακρός'' (') = large, ''φαγεῖν'' (') = to eat) are a type of white blood cell of the immune system that engulfs and digests pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. The process is called phagocytosis, which acts to defend the host against infection and injury. These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense ( innate immunity) and also help initiate specific defense mechanisms ( adaptive immunity) by recruiting oth ...
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Salmonella
''Salmonella'' is a genus of rod-shaped (bacillus) Gram-negative bacteria of the family Enterobacteriaceae. The two species of ''Salmonella'' are ''Salmonella enterica'' and '' Salmonella bongori''. ''S. enterica'' is the type species and is further divided into six subspecies that include over 2,600 serotypes. ''Salmonella'' was named after Daniel Elmer Salmon (1850–1914), an American veterinary surgeon. ''Salmonella'' species are non-spore-forming, predominantly motile enterobacteria with cell diameters between about 0.7 and 1.5 μm, lengths from 2 to 5 μm, and peritrichous flagella (all around the cell body, allowing them to move). They are chemotrophs, obtaining their energy from oxidation and reduction reactions, using organic sources. They are also facultative anaerobes, capable of generating ATP with oxygen ("aerobically") when it is available, or using other electron acceptors or fermentation ("anaerobically") when oxygen is not available. ''Salmonella'' ...
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms ( palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''medical oncology''. The term ''chemotherapy'' has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). The development of therapies with specific molecular or genetic targets, ...
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Council Of Scientific And Industrial Research
The Council of Scientific and Industrial Research ( IAST: ''vaigyanik tathā audyogik anusandhāna pariṣada''), abbreviated as CSIR, was established by the Government of India in September 1942 as an autonomous body that has emerged as the largest research and development organisation in India. CSIR is also among the world's largest publicly funded R&D organisation which is pioneering sustained contribution to S&T human resource development in the country. , it runs 37 laboratories/institutes, 39 outreach centres, 3 Innovation Centres and 5 units throughout the nation, with a collective staff of over 14,000, including a total of 4,600 scientists and 8,000 technical and support personnel. Although it is mainly funded by the Ministry of Science and Technology, it operates as an autonomous body through the Societies Registration Act, 1860. The research and development activities of CSIR include aerospace engineering, structural engineering, ocean sciences, life sciences and ...
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National Institute Of Science Communication And Information Resources
The National Institute of Science Communication and Information Resources (NISCAIR), located at New Delhi, India, was an information science institute in India founded in 2002. In 2021, the institute was merged with National Institute of Science, Technology and Development Studies to form National Institute of Science Communication and Policy Research (NIScPR). It operated under the umbrella of the Council of Scientific and Industrial Research (CSIR) that comprise 38 other labs and institutes in India. The institute published several academic journals and magazines. History In 2002, the Indian Scientific Documentation Centre (INSDOC), which came into being in 1952 under CSIR, was merged with NISCOM in 2002, to form National Institute of Science Communication and Information Resources (NISCAIR). General services National Science Library services Open access 18 journals and 3 popular science magazines ('' Science Reporter'' and its Hindi and Urdu editions) published by CSI ...
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National Institute Of Immunology, India
National Institute of Immunology (NII) is an autonomous research institute located in New Delhi, under the Department of Biotechnology (DBT) for research in immunology. NII was established on 24 June 1981, with Prof. M. G. K. Menon as Chairman of its governing body. It has its origins in the ICMR–WHO Research & Training Centre in Immunology at the All India Institute of Medical Sciences (AIIMS), Delhi, which was merged with NII in 1982. However, NII continued to function from AIIMS laboratory of its honorary Director Prof G.P. Talwar, till its new building was constructed in 1983, carved out of the Jawaharlal Nehru University Jawaharlal Nehru University (JNU) is a public major research university located in New Delhi, India. It was established in 1969 and named after Jawaharlal Nehru, India's first Prime Minister. The university is known for leading faculties and r ... (JNU) campus.
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Institute Of Microbial Technology
The Institute of Microbial Technology (IMTECH), based in Chandigarh, India, is one of the constituent establishments of the Council of Scientific & Industrial Research (CSIR). It was established in 1984. The institute is engaged in research in many areas of modern biological sciences and microbe-related biotechnology, with special emphasis on research that is interdisciplinary and of a collaborative nature, such as immunity and infectious diseases, protein design and engineering, fermentation science, microbial physiology and genetics, yeast biology, bioinformatics, microbial systematics, exploitation of microbial diversity for bioactives and enzymes for biotransformations. Present Director is Dr Sanjeev Khosla, and former directors were Dr Anil Koul, and Dr Girish Sahni. Facilities The institute is equipped with facilities for modern biology research. They include lab-to-pilot-scale fermenter of many capacities, tissue and cell culture facility, facility for maintenance, pr ...
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