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Sabcomeline
Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It made it to phase III clinical trials before being discontinued due to poor results. It is a non-selective agonist of all five muscarinic acetylcholine receptors with similar affinities. However, functional selectivity for the M1 receptor has been claimed ''in vitro'' and ''in vivo Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, an ...''. See also * Alvameline * Milameline * Tazomeline * Xanomeline References {{Muscarinic acetylcholine receptor modulators Abandoned drugs Experimental drugs Ketoxime ethers M1 receptor agonists M2 receptor agonists M3 receptor agonists M4 receptor agonists M5 receptor agonists Nitril ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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Milameline
Milameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued. *Changing the ''O''-methyl aldoxime to an ''O''-propargyl oxime instead gives a separate molecule called RU 35986. See also * Alvameline * Sabcomeline * Tazomeline * Xanomeline Xanomeline (developmental code name LY-246,708) is a small molecule muscarinic acetylcholine receptor agonist that was synthesized in a collaboration between Eli Lilly and Novo Nordisk as an investigational therapeutic being studied for the tre ... References {{Muscarinic acetylcholine receptor modulators Abandoned drugs Aldoximes M1 receptor agonists M2 receptor agonists M3 receptor agonists M4 receptor agonists M5 receptor agonists Oxime ethers Tetrahydropyridines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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Tazomeline
Tazomeline (LY-287,041) is a drug which acts as a non- selective muscarinic acetylcholine receptor agonist. It was in clinical trials for the treatment of cognitive dysfunction such as that seen in Alzheimer's disease and schizophrenia, but development was apparently scrapped for unknown reasons. Another of the patented uses is for the treatment of "severe painful conditions". See also * Alvameline * Milameline * Sabcomeline * Xanomeline Xanomeline (developmental code name LY-246,708) is a small molecule muscarinic acetylcholine receptor agonist that was synthesized in a collaboration between Eli Lilly and Novo Nordisk as an investigational therapeutic being studied for the tre ... References {{Muscarinic acetylcholine receptor modulators Abandoned drugs M1 receptor agonists Muscarinic agonists Tetrahydropyridines Thiadiazoles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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Alvameline
Alvameline (Lu 25-109) is a M1 receptor agonist and M2/ M3 receptor antagonist that was under investigation for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued. See also * Milameline * Sabcomeline * Tazomeline * Xanomeline Xanomeline (developmental code name LY-246,708) is a small molecule muscarinic acetylcholine receptor agonist that was synthesized in a collaboration between Eli Lilly and Novo Nordisk as an investigational therapeutic being studied for the tre ... References {{Muscarinic acetylcholine receptor modulators Abandoned drugs M1 receptor agonists M2 receptor antagonists M3 receptor antagonists Tetrahydropyridines Tetrazoles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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M5 Receptor Agonists
M5, M-5, M.5, M-V, or M05 may refer to: Transportation Automobiles * AITO M5, a Chinese mid-size crossover SUV * BMW M5, a German mid-size performance car series * Dongfeng Fengxing Lingzhi M5, a Chinese MPV * Haima M5, a Chinese compact sedan * JAC Refine M5, a Chinese MPV * Studebaker M5, an American pickup truck Aviation and aerospace * M-5 rocket, a Japanese rocket * Macchi M.5, an Italian flying boat fighter in service from 1917 until the mid-1920s * Miles M.5 Sparrowhawk, a 1930s British single-seat racing and touring monoplane * Fokker M.5, a 1913 unarmed single-seat monoplane aircraft * Grigorovich M-5, a Russian World War I-era biplane flying boat * Kenmore Air (IATA airline designator: M5), a small airline based in the United States Military * M5 Stuart, a variant of the Stuart tank, a World War II-era American light tank * M5 half-track, a variant of the M3 Half-track military armored personnel carrier * M5 tractor, World War II-era artillery-towing tractor * M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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M4 Receptor Agonists
M4 or M-4 most often refers to: * M4 carbine, an American carbine * M4 Sherman, an American World War II medium tank M4, M04, or M-4 may also refer to: Arts and entertainment * ''M4'' (EP), a 2006 EP by Faunts * ''M4'' (video game), a 1992 computer game developed for the Macintosh * ''M.IV'' ("Matrix IV"), the fictional Warner Brothers videogame project inside the 2021 film ''The Matrix Resurrections'' * Former name of band First to Eleven * M4, the robot assistant to the character Flint in the Star Trek episode Requiem for Methuselah Military Weapons * Benelli M4 Super 90, an Italian semi-automatic,gas-operated shotgun * M4 autocannon, an American 37 mm automatic gun * M4 Selectable Lightweight Attack Munition (SLAM), an American land mine * M4 SLBM, a French submarine-launched ballistic missile from 1985 * M4 Survival Rifle, an American rifle in aircraft survival gear * Spectre M4, an Italian submachine gun * M4 bayonet, an American World War II bayonet use ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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M3 Receptor Agonists
M3, M-3 or M03 may refer to: Computing and electronics * Apple M3, a central processing unit in the Apple M series * Intel m3, a brand of microprocessors * M.3 (aka NF1/NGSFF), a specification for internally mounted expansion cards * Leica M3, a landmark 35mm rangefinder camera * Modula-3 (M3), a programming language * M3, a British peak programme meter standard used for measuring the volume of audio broadcasts * m3, a macro processor for the AP-3 minicomputer, the predecessor to m4 * M3, a surface-mount version of the 1N4003 general-purpose silicon rectifier diode * M3 (email client), an unreleased email client for the Vivaldi browser Entertainment * M3, a comic book created by Vicente Alcazar * M3 adapter, a Game Boy Advance movie player * M3 (Canadian TV channel), a music and entertainment television channel * M3 (Hungarian TV channel), a Hungarian television channel * '' M3: Malay Mo Ma-develop'', a 2010 Philippine TV series * M3 Music Card, a 2007 flash-based MP3 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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M2 Receptor Agonists
M, or m, is the thirteenth letter of the Latin alphabet, used in the modern English alphabet, the alphabets of several western European languages and others worldwide. Its name in English is ''em'' (pronounced ), plural ''ems''. History The letter M is derived from the Phoenician Mem via the Greek Mu (Μ, μ). Semitic Mem is most likely derived from a " Proto-Sinaitic" (Bronze Age) adoption of the "water" ideogram in Egyptian writing. The Egyptian sign had the acrophonic value , from the Egyptian word for "water", ''nt''; the adoption as the Semitic letter for was presumably also on acrophonic grounds, from the Semitic word for "water", '' *mā(y)-''. Use in writing systems English In English, represents the voiced bilabial nasal . The Oxford English Dictionary (first edition) says that is sometimes a vowel, such as in words like ''spasm'' and in the suffix ''-ism''. In modern terminology, this is described as a syllabic consonant (IPA: ). M is the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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M1 Receptor Agonists
M1, M01 or M-1 may refer to: Arts, entertainment & media * M-1 (rapper), one half of hip hop duo Dead Prez * Korg M1, a keyboard synthesizer * Leica M1, a 1959 35 mm camera model * Olympus OM-1, a 1972 manually operated 35mm single-lens reflex camera * M1 (TV channel), news channel of the Hungarian MTVA * M-1 (Lithuanian radio station) * M1 (Ukraine), a television channel * M1 (Russian TV channel) Economics and finance * M1 (money supply measure), in economics, a measure of the money supply * M1 Finance, an online financial services company Military equipment Vehicles US Armed Forces * M1 Abrams, a main battle tank * M1 armored car * M1 combat car, an early tank * M1 light tractor * M1 medium tractor * M1 heavy tractor Other * Bristol M.1, a 1916 British fighter aircraft * (M1), a WWI Royal Navy monitor * (1919), an early British submarine * , a Swedish Navy mine sweeper * , a Swedish Royal Navy mine layer Weapons US Armed Forces * 120 mm gun M1, an anti- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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Ketoxime Ethers
In organic chemistry, an oxime is an organic compound belonging to the imines, with the general formula , where R is an organic side-chain and R' may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime. O-substituted oximes form a closely related family of compounds. Amidoximes are oximes of amides () with general structure . Oximes are usually generated by the reaction of hydroxylamine with aldehydes () or ketones (). The term ''oxime'' dates back to the 19th century, a combination of the words ''oxygen'' and ''imine''. Structure and properties If the two side-chains on the central carbon are different from each other—either an aldoxime, or a ketoxime with two different "R" groups—the oxime can often have two different geometric stereoisomeric forms according to the ''E''/''Z'' configuration. An older terminology of ''syn'' and ''anti'' was used to identify especially aldoximes according to whether the R group was closer or further from the hyd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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Experimental Drugs
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and informal natural comparisons ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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Abandoned Drugs
Abandon, abandoned, or abandonment may refer to: Common uses * Abandonment (emotional), a subjective emotional state in which people feel undesired, left behind, insecure, or discarded * Abandonment (legal), a legal term regarding property ** Child abandonment, the extralegal abandonment of children ** Lost, mislaid, and abandoned property, legal status of property after abandonment and rediscovery * Abandonment (mysticism) Art, entertainment, and media Film * ''Abandon'' (film), a 2002 film starring Katie Holmes * ''Abandoned'' (1949 film), starring Dennis O'Keefe * ''Abandoned'' (1955 film), the English language title of the Italian war film ''Gli Sbandati'' * ''Abandoned'' (2001 film), a Hungarian film * ''Abandoned'' (2010 film), starring Brittany Murphy * ''Abandoned'' (2015 film), a television movie about the shipwreck of the ''Rose-Noëlle'' in 1989 * ''Abandoned'' (2022 film), starring Emma Roberts * ''The Abandoned'' (1945 film), a 1945 Mexican film * ''The Aba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
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Xanomeline
Xanomeline (developmental code name LY-246,708) is a small molecule muscarinic acetylcholine receptor agonist that was synthesized in a collaboration between Eli Lilly and Novo Nordisk as an investigational therapeutic being studied for the treatment of central nervous system (CNS) disorders. Its pharmacological action is mediated primarily through stimulation of central nervous system muscarinic M1 and M4 receptor subtypes. Xanomeline is a non-selective muscarinic acetylcholine receptor agonist with similar high affinity for all five muscarinic acetylcholine receptor subtypes but has greater agonistic activity at the M1 and M4 subtypes. Xanomeline/trospium (Cobenfy), is a combination medication used in the treatment of schizophrenia. Pharmacology Pharmacodynamics Muscarinic acetylcholine receptor agonist Xanomeline is an agonist that primarily targets the muscarinic acetylcholine receptor family of five muscarinic receptor subtypes, which are designated M1-M5. Whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |