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SSHHPS
SSHHPS is an acronym for short stretches of homologous host pathogen sequences. The acronym was first coined by Legler in a 2019 publication. Legler used BLAST to search for host protein substrates for the nsP2 protease of the Venezuelan equine encephalitis virus (VEEV) and the protease from Zika virus. These viruses are Group 4 (+)ssRNA viruses. Short ~20–25 amino acid sequences from the viral polyprotein containing the scissile bond were used to search the human proteome. Many of the sequence alignments were spurious, while some matched well with the residues surrounding the scissile bond. When all known host proteins shown to be cut by viral proteases were consolidated into a table, it became clear that the targets were not random. Most were related to innate immunity while others appeared to be related to viral pathogenesis and the virus-induced phenotype. Some hits were related to both. The list of experimentally confirmed host targets of Group IV viral proteases in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GPR124
Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the ''GPR124'' gene. It is a member of the adhesion-GPCR Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein Receptor (biochemistry), receptors with a broad distribution in embryonic and larval cells, cells of the reproductive tract, neurons, leukocytes, and a variety ... family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing ( GAIN) domain. Interactions GPR124 has been shown to interact with DLG1 and is involved in the Wnt/β-catenin signaling pathway along with RECK. GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain. GPR124 (ADGRA2) was predicted using SSHHPS. Zebrafish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |