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SB-221284
SB-221284 is a binding selectivity, selective serotonin 5-HT2C receptor, 5-HT2C and 5-HT2B receptor, 5-HT2B receptor receptor antagonist, antagonist which is used in scientific research. Its affinity (pharmacology), affinities (Ki) are 2.2 to 2.5nM for the serotonin 5-HT2C receptor, 2.5 to 12.6nM for the serotonin 5-HT2B receptor, and 398 to 550nM for the serotonin 5-HT2A receptor, 5-HT2A receptor (where it is also an antagonist). The drug has 160- to 250-fold binding selectivity, selectivity for the serotonin 5-HT2C receptor over the serotonin 5-HT2A receptor. It is said to have been the first serotonin 5-HT2C receptor ligand (biochemistry), ligand to show 100-fold selectivity over the serotonin 5-HT2A receptor. SB-221284 has shown anxiolytic-like effects in animals. Conversely, it has been said to be inactive in terms of antidepressant-like, antiobsessional-like, antipanic-like, and sedative effects. It also showed no proconvulsant or hyperphagic effects in animals, phenotypes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypolocomotion
Locomotor activity is a measure of animal behavior which is employed in scientific research. Hyperlocomotion, also known as locomotor hyperactivity, hyperactivity, or increased locomotor activity, is an effect of certain drugs in animals in which locomotor activity (locomotion) is increased. It is induced by certain drugs like psychostimulants and NMDA receptor antagonists and is reversed by certain other drugs like antipsychotics and certain antidepressants. Stimulation of locomotor activity is thought to be mediated by increased signaling in the nucleus accumbens, a major brain area involved in behavioral activation and motivation, motivated behavior. Hypolocomotion, also known as locomotor hypoactivity, hypoactivity, and decreased locomotor activity, is an effect of certain drugs in animals in which locomotor activity is decreased. It is a characteristic effect of many sedative agents and general anesthetics. Antipsychotics, which are dopamine receptor antagonists, and many s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |