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Rudolf Jaenisch
Rudolf Jaenisch (born April 22, 1942) is a Professor of Biology at MIT and a founding member of the Whitehead Institute for Biomedical Research. He is a pioneer of transgenic science, in which an animal’s genetic makeup is altered. Jaenisch has focused on creating genetically modified mice to study cancer and neurological diseases. Research Jaenisch’s first breakthrough occurred in 1974 when he and Beatrice Mintz showed that foreign DNA could be integrated into the DNA of early mouse embryos. They injected retrovirus DNA into early mouse embryos and showed that leukemia DNA sequences had integrated into the mouse genome and also to its offspring. These mice were the first transgenic mammals in history. His current research focuses on the epigenetic regulation of gene expression, which has led to major advances in creating embryonic stem cells and “ induced pluripotent stem" (IPS) cells, as well as their therapeutic applications. In 2007, Jaenisch’s laboratory was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Międzygórze, Lower Silesian Voivodeship
Międzygórze (; german: Wölfelsgrund, ) is a village in the administrative district of Gmina Bystrzyca Kłodzka, within Kłodzko County, Lower Silesian Voivodeship, in south-western Poland. It lies approximately south-east of Bystrzyca Kłodzka, south of Kłodzko, and south of the regional capital Wrocław. The village has a population of 700. Notable residents * Rudolf Jaenisch Rudolf Jaenisch (born April 22, 1942) is a Professor of Biology at MIT and a founding member of the Whitehead Institute for Biomedical Research. He is a pioneer of transgenic science, in which an animal’s genetic makeup is altered. Jaenisch ... (born 1942), German scientist References Villages in Kłodzko County {{Kłodzko-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Therapeutic Cloning
In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. The technique consists of taking an enucleated oocyte (egg cell) and implanting a donor nucleus from a somatic (body) cell. It is used in both therapeutic and reproductive cloning. In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques (named Zhong Zhong and Hua Hua) from foetal nuclei. "Therapeutic cloning" refers to the potential use of SCNT in regenerative medicine; this approach has been championed as an answer to the many issues concerning embryonic stem cells (ESCs) and the destruction of viable embryos for medical use, though questions remain on how homologous the two cell types truly are. Introduction Somatic cell nuclear transfer is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurological Disease
A neurological disorder is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. Examples of symptoms include paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness. There are many recognized neurological disorders, some relatively common, but many rare. They may be assessed by neurological examination, and studied and treated within the specialities of neurology and clinical neuropsychology. Interventions foneurological disordersinclude preventive measures, lifestyle changes, physiotherapy or other therapy, neurorehabilitation, pain management, medication, operations performed by neurosurgeons or a specific diet. The World Health Organization estimated in 2006 that neurological disorders and their sequelae (direct consequences) affect as many as one billion people worldwide, and identified healt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as '' Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Mouse
A genetically modified mouse or genetically engineered mouse model (GEMM) is a mouse (''Mus musculus'') that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases, and are also used for research on genes. Together with patient-derived xenografts (PDXs), GEMMs are the most common ''in vivo'' models in cancer research. Both approaches are considered complementary and may be used to recapitulate different aspects of disease. GEMMs are also of great interest for drug development, as they facilitate target validation and the study of response, resistance, toxicity and pharmacodynamics. History In 1974 Beatrice Mintz and Rudolf Jaenisch created the first genetically modified animal by inserting a DNA virus into an early-stage mouse embryo and showing that the inserted genes were present in every cell. However, the mice did not pass the transgene to their offspring, and th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transgenics
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". A wide variety of organisms have been genetically modified (GM), from animals to plants and microorganisms. Genes have been transferred within the same species, across species (creating transgenic organisms), and even across kingdoms. New genes can be introduced, or endogenous genes can be enhanced, altered, or knocked out. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with other genetic elements, including a promoter and terminator region and often a selectable marker. A number of techniques are ava ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Whitehead Institute
Whitehead Institute for Biomedical Research is a non-profit research institute located in Cambridge, Massachusetts, United States that is dedicated to improving human health through basic biomedical research. It was founded as a fiscally independent entity from the Massachusetts Institute of Technology (MIT), where its 18 members all hold faculty appointments in the MIT Department of Biology or the MIT Department of Bioengineering. Two members (Rudolf Jaenisch, 2010, and Robert Weinberg, 1997) are National Medal of Science recipients; ten have been elected to the National Academy of Sciences; and four have been elected to the National Academy of Medicine; six are Howard Hughes Medical Institute Investigators. In September 2019, Ruth Lehmann was announced as the new director of the Whitehead Institute for Biomedical Research, commencing July 2020 and succeeding David Page. History Whitehead Institute was founded in 1982 by industrialist and philanthropist Edwin C. “Jack� ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Medal Of Science
The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social sciences, biology, chemistry, engineering, mathematics and physics. The twelve member presidential Committee on the National Medal of Science is responsible for selecting award recipients and is administered by the National Science Foundation (NSF). History The National Medal of Science was established on August 25, 1959, by an act of the Congress of the United States under . The medal was originally to honor scientists in the fields of the "physical, biological, mathematical, or engineering sciences". The Committee on the National Medal of Science was established on August 23, 1961, by executive order 10961 of President John F. Kennedy. On January 7, 1979, the American Association for the Advancement of Science (AAAS) passed a resolution ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wolf Prize In Medicine
The Wolf Prize in Medicine is awarded annually by the Wolf Foundation in Israel. It is one of the six Wolf Prizes established by the Foundation and awarded since 1978; the others are in Agriculture, Chemistry, Mathematics, Physics and Arts. The Prize has been stated to be the second most prestigious award in science, and a significant predictor of the Nobel Prize. Laureates Source: Laureates per country Below is a chart of all laureates per country (updated to 2022 laureates). Some laureates are counted more than once if have multiple citizenship. See also * List of medicine awards Notes and references External links * * * Wolf Prizes 2015Jerusalempost Israel-Wolf-Prizes 2016Jerusalempost Israel-Wolf-Prizes 2017Wolf Prize 2019 {{DEFAULTSORT:Wolf Prize In Medicine Medicine awards Medicine Medicine is the science and Praxis (process), practice of caring for a patient, managing the diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keck School Of Medicine
The Keck School of Medicine of the University of Southern California teaches and trains physicians, biomedical scientists and other healthcare professionals, conducts medical research, and treats patients. Founded in 1885, it is the second oldest medical school in California after the UCSF School of Medicine. It is located on the university's health sciences campus in northeastern Los Angeles which is adjacent to the Boyle Heights and Lincoln Heights neighborhoods. For the physician class of 2024, the average GPA was 3.8 and the average MCAT score was 517. Programs In addition to a medical degree (MD), the school offers various combined degrees, such as MD/MPH, MD/PhD and MD/MBA. The school offers separate master's and doctoral degree programs in various biomedical fields. It also offers programs in physician assistantship and nurse anesthesia. The joint MD-PhD program is part of a cooperation with the California Institute of Technology located in nearby Pasadena. USC als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massry Prize
The Massry Prize was established in 1996, and until 2009 was administered by the Meira and Shaul G. Massry Foundation. The Prize, of $40,000 and the Massry Lectureship, is bestowed upon scientists who have made substantial recent contributions in the biomedical sciences. Shaul G. Massry, M.D., who established the Massry Foundation, is Professor Emeritus of Medicine and Physiology and Biophysics at the Keck School of Medicine, University of Southern California. He served as Chief of its Division of Nephrology from 1974 to 2000. In 2009 the KECK School of Medicine was asked to administer the Prize, and has done so since that time. Ten winners of the Massry Prize have gone on to be awarded a Nobel Prize. Previous laureates SourceKECK School of Medicine* 1996 Michael Berridge in the field of Signal Transduction * 1997 Judah Folkman in the field of Growth Factors * 1998 Mark Ptashne in the field of Regulation of Transcription * 1999 Gunter Blobel in the field of Protein Traffi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Delbrück Medal
The Max Delbrück Medal has been awarded annually from 1992 to 2013 by the Max Delbrück Center for Molecular Medicine (German: ''Max-Delbrück-Centrum für Molekulare Medizin'' or MDC). Named after the German biophysicist Max Delbrück, it is presented in Berlin to an outstanding scientist on the occasion of the annual "Berlin Lecture on Molecular Medicine", which the MDC organizes together with other Berlin research institutions and Bayer HealthCare. The award recipient usually delivers a lecture after the award. Recipients SourceMDC* 1992: Günter Blobel, Rockefeller University of New York, US * 1993: ''no award'' * 1994: Sydney Brenner, Cambridge University, England * 1995: Jean-Pierre Changeux, Pasteur Institute, Paris * 1996: Robert Allan Weinberg, Whitehead Institute, Cambridge, US * 1997: Charles Weissmann, Zürich University, Switzerland * 1998: Svante Pääbo, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany * 1999: Paul Berg, Stanford University ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
