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Roy Calne
Sir Roy Yorke Calne (30 December 1930 – 6 January 2024) was a British surgeon and pioneer in organ transplantation. He was part of the team that performed the first liver transplantation operation in Europe in 1968, the world's first liver, heart transplantation, heart and lung transplantation in 1987, the first intestines, intestinal transplant in the UK in 1992 and the first successful combined stomach, intestine, pancreas, liver and kidney transplantation, kidney cluster transplantation in 1994. In 1960, Calne showed that 6-mercaptopurine (6-MP) could prolong the survival of a allotransplantation, transplanted kidney in a dog, and later showed that azathioprine was more effective. Through the mid-1960s, he worked to develop solutions in surgical techniques and organ rejection. In the late 1970s, he began to experiment with the immunosuppressant Ciclosporin, ciclosporin A, which was then introduced into regular use to prevent Transplant rejection, organ rejection. Calne wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laurence Broderick
Laurence Broderick (18 June 1935 – 18 April 2024) was a British sculptor. His best known work is 'The Bull', a public sculpture erected in 2003 at the Bull Ring, Birmingham, Bull Ring, Birmingham. ''The Bull'' is about 4.5 meters long, about 220 cm high and weighs about 6.5 tons. It is one of the largest bronze animal sculptures in the country. His work consists largely of figurative art, figurative carvings in stone and editions in bronze. Early life Broderick was born in Bristol, in the west of England, on 18 June 1935, and attended Bembridge School on the Isle of Wight. He studied painting, illustration and sculpture under Ray Millard and Geoffrey Deeley at the University of Westminster, Regent Street Polytechnic from 1952 to 1957, and with Sidney Harpley and Keith Godwin at the Hammersmith School of Art from 1964 to 1965. Career Broderick began his artistic career as an historical and educational illustrator and painter. He taught Art at the Haberdashers' Aske's B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stomach
The stomach is a muscular, hollow organ in the upper gastrointestinal tract of Human, humans and many other animals, including several invertebrates. The Ancient Greek name for the stomach is ''gaster'' which is used as ''gastric'' in medical terms related to the stomach. The stomach has a dilated structure and functions as a vital organ in the digestive system. The stomach is involved in the gastric phase, gastric phase of digestion, following the cephalic phase in which the sight and smell of food and the act of chewing are stimuli. In the stomach a chemical breakdown of food takes place by means of secreted digestive enzymes and gastric acid. It also plays a role in regulating gut microbiota, influencing digestion and overall health. The stomach is located between the esophagus and the small intestine. The pyloric sphincter controls the passage of partially digested food (chyme) from the stomach into the duodenum, the first and shortest part of the small intestine, where p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Guardian
''The Guardian'' is a British daily newspaper. It was founded in Manchester in 1821 as ''The Manchester Guardian'' and changed its name in 1959, followed by a move to London. Along with its sister paper, ''The Guardian Weekly'', ''The Guardian'' is part of the Guardian Media Group, owned by the Scott Trust Limited. The trust was created in 1936 to "secure the financial and editorial independence of ''The Guardian'' in perpetuity and to safeguard the journalistic freedom and liberal values of ''The Guardian'' free from commercial or political interference". The trust was converted into a limited company in 2008, with a constitution written so as to maintain for ''The Guardian'' the same protections as were built into the structure of the Scott Trust by its creators. Profits are reinvested in its journalism rather than distributed to owners or shareholders. It is considered a newspaper of record in the UK. The editor-in-chief Katharine Viner succeeded Alan Rusbridger in 2015. S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas Starzl
Thomas Earl Starzl (March 11, 1926 – March 4, 2017) was an American physician, researcher, and expert on organ transplants. He performed the first human liver transplants, and has often been referred to as "the father of modern transplantation". A documentary, titled "Burden of Genius," covering the medical and scientific advances spearheaded by Starzl himself, was released to the public in 2017 in a series of screenings. Starzl also penned his autobiography, "The Puzzle People: Memoirs Of A Transplant Surgeon," which was published in 1992. Life Early years Starzl was born on March 11, 1926, in Le Mars, Iowa, the son of newspaper editor and science fiction writer Roman Frederick Starzl and Anna Laura Fitzgerald who was a teacher and a nurse. He was the second of four siblings. Originally intending to become a priest in his teenage years, Starzl changed his plans drastically when his mother died from breast cancer in 1947. Education He attended Westminster College in F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lasker Award
In 1945 Albert Lasker and Mary Woodard Lasker created the Lasker Awards. Every year since then the award has been given to the living person considered to have made the greatest contribution to medical science or who has demonstrated public service on behalf of medicine. They are administered by the Lasker Foundation. The Lasker is sometimes referred to as "America's Nobels". The Lasker Awards have gained a reputation for identifying future winners of the Nobel Prize. Eighty-six Lasker laureates have received the Nobel Prize, including 32 in the last two decades. Claire Pomeroy is the current president of the Lasker Foundation. Award The award is given in four branches of medical science: # Albert Lasker Basic Medical Research Award # Lasker–DeBakey Clinical Medical Research Award # Lasker–Bloomberg Public Service Award (Renamed in 2011 from Mary Woodard Lasker Public Service Award. Renamed in 2000 from Albert Lasker Public Service Award.) # '' Lasker–Koshland Speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Medicine
The Royal Society of Medicine (RSM) is a medical society based at 1 Wimpole Street, London, UK. It is a registered charity, with admission through membership. Its Chief Executive is Michele Acton. History The Royal Society of Medicine (RSM) was formed in 1907 when 17 individual medical societies merged with the Royal Medical and Chirurgical Society of London (RMCS), reflecting the growing acceptance of medical specialties at that time. Key figures in its founding included John MacAlister, the resident librarian at the RMCS since 1886, and his supporters Sir Richard Douglas Powell, Sir William Selby Church and Sir William Osler. 19th century Although the Society became the RSM in 1907, it is generally accepted by its historians that the origins date back to 1805, when John Yelloly, Alexander Marcet and William Saunders left the Medical Society of London (MSL) as a protest against its president James Sims, and created the Medical and Chirurgical Society of Lon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knight Bachelor
The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised Order of chivalry, orders of chivalry; it is a part of the Orders, decorations, and medals of the United Kingdom, British honours system. Knights Bachelor are the most ancient sort of British knight (the rank existed during the 13th-century reign of Henry III of England, King Henry III), but Knights Bachelor rank below knights of chivalric orders. A man who is knighted is formally addressed as "Sir [First Name] [Surname]" or "Sir [First Name]" and his wife as "Lady [Surname]". The designation "Bachelor" in this context conveys the concept of "junior in rank". Criteria Knighthood is usually conferred for public service; amongst its recipients are all male judges of His Majesty's High Court of Justice in England. It is possible to be a Knight Bachelor and a junior member of an order of chivalry without being a knight of that or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transplant Rejection
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types Transplant rejection can be classified into three types: hyperacute, acute, and chronic. These types are differentiated by how quickly the recipient's immune system is activated and the specific aspect or aspects of immunity involved. Hyperacute rejection Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. It is caused by the presence of pre-existing antibodies in the recipient that recognize antigens in the donor organ. These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, will lead to the rapid activation of the complement system. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ciclosporin
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken Oral administration, orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, eczema, and in organ transplants to prevent transplant rejection, rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes). Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects. Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azathioprine
Azathioprine, sold under the brand name Imuran, among others, is an immunosuppressive medication. It is used for the treatment of rheumatoid arthritis, granulomatosis with polyangiitis, Crohn's disease, ulcerative colitis, and systemic lupus erythematosus, and in kidney transplants to prevent transplant rejection, rejection. It is listed by the International Agency for Research on Cancer as a group 1 carcinogen, group 1 human carcinogen. It is taken by mouth or intravenous, injected into a vein. Common side effects include bone marrow suppression, bone-marrow suppression and vomiting. Bone-marrow suppression is especially common in people with a genetics, genetic deficiency of the enzyme thiopurine S-methyltransferase. Other serious risk factors include an increased risk of certain cancers. Use during pregnancy may result in harm to the baby. Azathioprine belongs to the purine analogues subclass of antimetabolites family of medications. It works via 6-thioguanine to disrupt the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allotransplantation
Allotransplant (''allo-'' meaning "other" in Greek) is the transplantation of cells, tissues, or organs to a recipient from a genetically non-identical donor of the same species. The transplant is called an allograft, allogeneic transplant, or homograft. Most human tissue and organ transplants are allografts. It is contrasted with autotransplantation (from one part of the body to another in the same person), syngenic transplantation of isografts (grafts transplanted between two genetically identical individuals) and xenotransplantation (from other species). Allografts can be referred to as "homostatic" if they are biologically inert when transplanted, such as bone and cartilage.(W. P. Longmire, ''J. National Cancer Institute'' 14, 669: ''The term ''homostatic graft'' might be applied to inert tissues such as bone and cartilage when transferred from one individual to another of the same species; and the term ''homovital graft'' might be used in reference to grafts whose ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
