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Relapsing Fever
Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus '' Borrelia'', which is transmitted through the bites of lice, soft-bodied ticks (genus '' Ornithodoros''), or hard-bodied ticks (Genus Ixodes). Signs and symptoms Most infected people develop sickness between 5 and 15 days after they are bitten. The symptoms may include a sudden fever, chills, headaches, muscle or joint aches, and nausea. A rash may also occur. These symptoms usually continue for 2 to 9 days, then disappear. This cycle may continue for several weeks if the person is not treated. Causes Louse-borne relapsing fever Along with '' Rickettsia prowazekii'' and '' Bartonella quintana'', '' Borrelia recurrentis'' is one of three pathogens of which the body louse ('' Pediculus humanus humanus'') is a vector. Louse-borne relapsing fever is more severe than the tick-borne variety. Louse-borne relapsing fever occurs in epidemics amid poor living conditions, famine, an ...
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Vector (epidemiology)
In epidemiology, a disease vector is any living agent that carries and transmits an infectious pathogen such as a parasite or microbe, to another living organism. Agents regarded as vectors are mostly blood-sucking (Hematophagy, hematophagous) arthropods such as mosquitoes. The first major discovery of a disease vector came from Ronald Ross in 1897, who discovered the malaria pathogen when he dissected the stomach tissue of a mosquito. Arthropods Arthropods form a major group of pathogen vectors with mosquitoes, Fly, flies, Sandfly, sand flies, lice, fleas, ticks, and mites transmitting a huge number of pathogens. Many such vectors are haematophagous, which feed on blood at some or all stages of their lives. When the insects and ticks feed on blood, the pathogen enters the blood stream of the host. This can happen in different ways. The ''Anopheles'' mosquito, a vector for malaria, filariasis, and various arthropod-borne-viruses (arboviruses), inserts its delicate mouthpart under ...
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Epidemic
An epidemic (from Greek ἐπί ''epi'' "upon or above" and δῆμος ''demos'' "people") is the rapid spread of disease to a large number of hosts in a given population within a short period of time. For example, in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic. Epidemics of infectious disease are generally caused by several factors including a change in the ecology of the host population (e.g., increased stress or increase in the density of a vector species), a genetic change in the pathogen reservoir or the introduction of an emerging pathogen to a host population (by movement of pathogen or host). Generally, an epidemic occurs when host immunity to either an established pathogen or newly emerging novel pathogen is suddenly reduced below that found in the endemic equilibrium and the transmission threshold is exceeded. An epidemic may be restricted to one location; however, if it sp ...
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Ornithodoros Sonrai
''Ornithodoros'' is a genus in the soft-bodied tick family, Argasidae. It is distinguished from other genera in the family by the absence of a lateral 'suture' line. It is the largest genus within Argasidae, consisting of approximately 130 species. ''Ornithodoros'' ticks are parasitic associates of shelter-seeking vertebrates, such as mammals, birds and reptiles. Prior to its reclassification in 1844, the genus ''Ornithodoros'' was described under the genus ''Argas''. Physiology The opening between the midgut and hindgut has been lost, preventing these ticks from excreting digestive waste products from their bodies. Habitat The genus ''Ornithodoros'' have been documented worldwide, with the highest occurrence in the Paleartic realm. Life Cycle The life cycle of all species of ''Ornithodoros'' is parasitic and relies on one or multiple hosts, most of which are shelter-seeking vertebrates, and can also parasitize humans. Mating and moulting occur in close proximity to site ...
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Carios Erraticus
''Carios erraticus'', formerly called ''Ornithodoros erraticus'', is a species of tick in the family Argasidae. The tick was described by Hippolyte Lucas in 1849. Description The tick is native to the Middle East and Mediterranean. It is one of the more common soft ticks to bite humans. Their main food sources in Spain are pigs; the tick has been found in pig pens in the provinces of Salamanca, Badajoz, and Huelva. The only human habitats the tick can enter are places in poor condition. Pathology This species carries the pathogenic Qalyub and African swine fever viruses and the spirochetes '' Borrelia crocidurae'' and '' Borrelia hispanica''. When the tick is infected by ''B. crocidurae'', the disease affects its genetic organ, the testes in males and the ovaries in females. The tick transmits the African swine fever virus only in Spain and Portugal. The tick feeds at night, ingesting blood to repletion in about 15 minutes. Small mammals are the most common hosts; this speci ...
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Tunisia
Tunisia, officially the Republic of Tunisia, is a country in the Maghreb region of North Africa. It is bordered by Algeria to the west and southwest, Libya to the southeast, and the Mediterranean Sea to the north and east. Tunisia also shares maritime borders with Italy through the islands of Sicily and Sardinia to the north and Malta to the east. It features the archaeological sites of Carthage dating back to the 9th century BC, as well as the Great Mosque of Kairouan. Known for its ancient architecture, Souks of Tunis, souks, and blue coasts, it covers , and has a population of 12.1 million. It contains the eastern end of the Atlas Mountains and the northern reaches of the Sahara desert; much of its remaining territory is arable land. Its of coastline includes the African conjunction of the western and eastern parts of the Mediterranean Basin. Tunisia is home to Africa's northernmost point, Cape Angela. Located on the northeastern coast, Tunis is the capital and List of cities ...
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Senegal
Senegal, officially the Republic of Senegal, is the westernmost country in West Africa, situated on the Atlantic Ocean coastline. It borders Mauritania to Mauritania–Senegal border, the north, Mali to Mali–Senegal border, the east, Guinea to Guinea–Senegal border, the southeast and Guinea-Bissau to Guinea-Bissau–Senegal border, the southwest. Senegal nearly surrounds The Gambia, a country occupying a narrow sliver of land along the banks of the Gambia River, which separates Senegal's southern region of Casamance from the rest of the country. It also shares a maritime border with Cape Verde. Senegal's capital is Dakar. Senegal is the westernmost country in the mainland of the Old World, or Afro-Eurasia. It owes its name to the Senegal River, which borders it to the east and north. The climate is typically Sahelian, though there is a wet season, rainy season. Senegal covers a land area of almost and has a population of around 18 million. The state is a Presidential system ...
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Mali
Mali, officially the Republic of Mali, is a landlocked country in West Africa. It is the List of African countries by area, eighth-largest country in Africa, with an area of over . The country is bordered to the north by Algeria, to the east by Niger, to the northwest by Mauritania, to the south by Burkina Faso and Ivory Coast, and to the west by Guinea and Senegal. The population of Mali is about 23.29 million, 47.19% of which are estimated to be under the age of 15 in 2024. Its Capital city, capital and largest city is Bamako. The country has 13 official languages, of which Bambara language, Bambara is the most commonly spoken. The sovereign state's northern borders reach deep into the middle of the Sahara, Sahara Desert. The country's southern part, where the majority of inhabitants live, is in the Sudanian savanna and has the Niger River, Niger and Senegal River, Senegal rivers running through it. The country's economy centres on agriculture and mining with its most promine ...
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Egypt
Egypt ( , ), officially the Arab Republic of Egypt, is a country spanning the Northeast Africa, northeast corner of Africa and Western Asia, southwest corner of Asia via the Sinai Peninsula. It is bordered by the Mediterranean Sea to northern coast of Egypt, the north, the Gaza Strip of Palestine and Israel to Egypt–Israel barrier, the northeast, the Red Sea to the east, Sudan to Egypt–Sudan border, the south, and Libya to Egypt–Libya border, the west; the Gulf of Aqaba in the northeast separates Egypt from Jordan and Saudi Arabia. Cairo is the capital, list of cities and towns in Egypt, largest city, and leading cultural center, while Alexandria is the second-largest city and an important hub of industry and tourism. With over 109 million inhabitants, Egypt is the List of African countries by population, third-most populous country in Africa and List of countries and dependencies by population, 15th-most populated in the world. Egypt has one of the longest histories o ...
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Borrelia Crocidurae
''Borrelia'' is a genus of bacteria of the spirochete phylum. Several species cause Lyme disease, also called Lyme borreliosis, a zoonotic, vector-borne disease transmitted by ticks. Other species of ''Borrelia'' cause relapsing fever, and are transmitted by ticks or lice, depending on the species of bacteria. The genus is named after French biologist Amédée Borrel (1867–1936), who first documented the distinction between a species of ''Borrelia anserina'' and the other known type of spirochete at the time, ''Treponema pallidum''. This bacterium must be viewed using dark-field microscopy, which make the cells appear white against a dark background. ''Borrelia'' species are grown in Barbour-Stoenner-Kelly medium. Of 52 known species of ''Borrelia'', 20 are members of the Lyme disease group (with an additional 3 proposed), 29 belong to the relapsing fever group, and two are members of a genetically distinct third group typically found in reptiles. A proposal has been made to ...
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Tick
Ticks are parasitic arachnids of the order Ixodida. They are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, and species, but can become larger when engorged. Ticks are external parasites, living by feeding on the blood of mammals, birds, and sometimes reptiles and amphibians. The timing of the origin of ticks is uncertain, though the oldest known tick fossils are around 100 million years old, and come from the Cretaceous period. Ticks are widely distributed around the world, especially in warm, humid climates. Ticks belong to two major families: the Ixodidae, or hard ticks, and the Argasidae, or soft ticks. '' Nuttalliella'', a genus of tick from southern Africa, is the only member of the family Nuttalliellidae, and represents the most primitive living lineage of ticks. Adults have ovoid/pear-shaped bodies (idiosomas) which become engorged with blood when they feed, and eight legs. Their cephalotho ...
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QT Interval
The QT interval is a measurement made on an Electrocardiography, electrocardiogram used to assess some of the electrical properties of the heart. It is calculated as the time from the start of the QRS complex, Q wave to the end of the T wave, and approximates to the time taken from when the Ventricle (heart), cardiac ventricles start to contract to when they finish relaxing. An abnormally long or abnormally short QT interval is associated with an increased risk of developing Heart arrhythmia, abnormal heart rhythms and Cardiac arrest, sudden cardiac death. Abnormalities in the QT interval can be caused by Genetics, genetic conditions such as long QT syndrome, by certain medications such as fluconazole, sotalol or pitolisant, by disturbances in the concentrations of certain Electrolyte, salts within the blood such as Hypokalemia, hypokalaemia, or by Endocrine disease, hormonal imbalances such as hypothyroidism. Measurement The QT interval is most commonly measured in Electrocardi ...
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Jaundice
Jaundice, also known as icterus, is a yellowish or, less frequently, greenish pigmentation of the skin and sclera due to high bilirubin levels. Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. The prevalence of jaundice in adults is rare, while jaundice in babies is common, with an estimated 80% affected during their first week of life. The most commonly associated symptoms of jaundice are itchiness, pale feces, and dark urine. Normal levels of bilirubin in blood are below 1.0  mg/ dl (17  μmol/ L), while levels over 2–3 mg/dl (34–51 μmol/L) typically result in jaundice. High blood bilirubin is divided into two types: unconjugated and conjugated bilirubin. Causes of jaundice vary from relatively benign to potentially fatal. High unconjugated bilirubin may be due to excess red blood cell breakdown, large bruises, gen ...
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