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Registry Of Toxic Effects Of Chemical Substances
Registry of Toxic Effects of Chemical Substances (RTECS) is a database of toxicity information compiled from the open scientific literature without reference to the validity or usefulness of the studies reported. Until 2001 it was maintained by US National Institute for Occupational Safety and Health (NIOSH) as a freely available publication. It is now maintained by the private company BIOVIA. Contents Six types of toxicity data are included in the file: # Primary irritation # Mutagenic effects # Reproductive effects # Tumorigenic effects # Acute toxicity # Other multiple dose toxicity Specific numeric toxicity values such as , LC50, TDLo, and TCLo are noted as well as species studied and the route of administration used. For all data the bibliographic source is listed. The studies are not evaluated in any way. History RTECS was an activity mandated by the US Congress, established by Section 20(a)(6) of the Occupational Safety and Health Act of 1970 (PL 91-596). The ori ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data or a type of data store based on the use of a database management system (DBMS), the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an application associated with the database. Before digital storage and retrieval of data have become widespread, index cards were used for data storage in a wide range of applications and environments: in the home to record and store recipes, shopping lists, contact information and other organizational data; in business to record presentation notes, project research and notes, and contact information; in schools as flash c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Species
A species () is often defined as the largest group of organisms in which any two individuals of the appropriate sexes or mating types can produce fertile offspring, typically by sexual reproduction. It is the basic unit of Taxonomy (biology), classification and a taxonomic rank of an organism, as well as a unit of biodiversity. Other ways of defining species include their karyotype, DNA sequence, morphology (biology), morphology, behaviour, or ecological niche. In addition, palaeontologists use the concept of the chronospecies since fossil reproduction cannot be examined. The most recent rigorous estimate for the total number of species of eukaryotes is between 8 and 8.7 million. About 14% of these had been described by 2011. All species (except viruses) are given a binomial nomenclature, two-part name, a "binomen". The first part of a binomen is the name of a genus to which the species belongs. The second part is called the specific name (zoology), specific name or the specific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Databases
A chemical database is a database specifically designed to store chemical information. This information is about chemical and crystal structures, spectra, reactions and syntheses, and thermophysical data. Types of chemical databases Bioactivity database Bioactivity databases correlate structures or other chemical information to bioactivity results taken from bioassays in literature, patents, and screening programs. Chemical structures Chemical structures are traditionally represented using lines indicating chemical bonds between atoms and drawn on paper (2D structural formulae). While these are ideal visual representations for the chemist, they are unsuitable for computational use and especially for search and storage. Small molecules (also called ligands in drug design applications), are usually represented using lists of atoms and their connections. Large molecules such as proteins are however more compactly represented using the sequences of their amino acid buil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Safety
Chemical safety includes all safety policies, procedures and practices designed to minimize the risk of exposure to potentially hazardous chemicals. This includes the risks of exposure to persons handling the chemicals, to the surrounding environment, and to the communities and ecosystems within that environment. Manufactured chemicals, either pure or in mixtures, solutions and emulsions, are ubiquitous in modern society, at industrial, occupational and private scale. However, there are chemicals that should not mix or get in contact with others, as they can produce byproducts that may be toxic, carcinogenic, explosive etc., or can be dangerous in themselves. To avoid disasters and mishaps, maintaining safety is paramount. Chemical safety refers to safety issues surrounding the use, production, transport and handling of chemicals at large or small manufacturing facilities, laboratories, non-chemical sites that use manufactured chemicals for their business, or homes during everyday a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemistry Databases
Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all areas of the life sciences are being uncovered and developed through biochemical methodology and research. Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis that allows biological molecules to give rise to the processes that occur within living cells and between cells, Karp (2009), p. 2. in turn relating greatly to the understanding of tissues and organs as well as organism structure and function.Miller (2012). p. 62. Biochemistry is closely related to molecular biology, the study of the molecular mechanisms of biological phenomena.Astbury (196 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dassault Systèmes
Dassault Systèmes SE () (abbreviated 3DS) is a French Multinational corporation, multinational software corporation which develops software for 3D product design, simulation, manufacturing and other 3D related products. Founded in 1981, it is headquartered in Vélizy-Villacoublay, France, and has 23,811 employees across 194 global offices. History 1980s Dassault Systèmes (also known as 3DS) grew out of the aerospace industry's search for more sophisticated drafting tools to streamline the development process and aid in the increasing complexity of aviation design. Dassault Systèmes spun out in 1981 (as part of Dassault Group) to develop and market their 3D surface design software CATI, later renamed CATIA. That same year, Dassault Systèmes signed a sales and marketing agreement with IBM, allowing IBM to resell the CATIA Computer-aided design, CAD software. 1990s In the 1990s, Dassault Systèmes' software was used to develop seven out of every ten new airplanes and fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elsevier
Elsevier ( ) is a Dutch academic publishing company specializing in scientific, technical, and medical content. Its products include journals such as ''The Lancet'', ''Cell (journal), Cell'', the ScienceDirect collection of electronic journals, ''Trends (journals), Trends'', the ''Current Opinion (Elsevier), Current Opinion'' series, the online citation database Scopus, the SciVal tool for measuring research performance, the ClinicalKey search engine for clinicians, and the ClinicalPath evidence-based cancer care service. Elsevier's products and services include digital tools for Data management platform, data management, instruction, research analytics, and assessment. Elsevier is part of the RELX Group, known until 2015 as Reed Elsevier, a publicly traded company. According to RELX reports, in 2022 Elsevier published more than 600,000 articles annually in over 2,800 journals. As of 2018, its archives contained over 17 million documents and 40,000 Ebook, e-books, with over one b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDL Information Systems
MDL Information Systems, Inc. was a provider of R&D informatics products for the life sciences and chemicals industries. The company was launched as a computer-aided drug design firm (originally named Molecular Design Limited, Inc.) in January 1978 in Hayward, California. The company was acquired by Symyx Technologies, Inc. in 2007. Subsequently Accelrys merged with Symyx. The Accelrys name was retained for the combined company. In 2014 Accelrys was acquired by Dassault Systèmes. The Accelrys business unit was renamed BIOVIA. History Molecular Design Limited, Inc. was founded by Stuart Marson and W. Todd Wipke in 1978. With 15 years of research on computer synthesis at the University of California, Santa Cruz, Wipke, with Marson, fresh from a Ph.D. at Stanford University and a postdoctoral stint at the University of California, Berkeley, were convinced that computer-assisted molecular design was possible as a commercial enterprise.C&EN, June 18, 1979 Employee #3 was Stephen P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical
A chemical substance is a unique form of matter with constant chemical composition and characteristic properties. Chemical substances may take the form of a single element or chemical compounds. If two or more chemical substances can be combined without reacting, they may form a chemical mixture. If a mixture is separated to isolate one chemical substance to a desired degree, the resulting substance is said to be chemically pure. Chemical substances can exist in several different physical states or phases (e.g. solids, liquids, gases, or plasma) without changing their chemical composition. Substances transition between these phases of matter in response to changes in temperature or pressure. Some chemical substances can be combined or converted into new substances by means of chemical reactions. Chemicals that do not possess this ability are said to be inert. Pure water is an example of a chemical substance, with a constant composition of two hydrogen atoms bonded to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Occupational Safety And Health Act
The Occupational Safety and Health Act of 1970 is a US labor law governing the federal law of occupational health and safety in the private sector and federal government in the United States. It was enacted by Congress in 1970 and was signed by President Richard Nixon on December 29, 1970. Its main goal is to ensure that employers provide employees with an environment free from recognized hazards, such as exposure to toxic chemicals, excessive noise levels, mechanical dangers, heat or cold stress, or unsanitary conditions. The Act created the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH). The Act can be found in the United States Code at title 29, chapter 15. History of federal workplace safety legislation Few workplace health and safety protections were available through the federal government before the passage of OSHA. The American system of mass production encouraged the use of machinery, while t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
US Congress
The United States Congress is the legislature, legislative branch of the federal government of the United States. It is a Bicameralism, bicameral legislature, including a Lower house, lower body, the United States House of Representatives, U.S. House of Representatives, and an Upper house, upper body, the United States Senate, U.S. Senate. They both meet in the United States Capitol in Washington, D.C. Members of Congress are chosen through direct election, though vacancies in the Senate may be filled by a Governor (United States), governor's appointment. Congress has a total of 535 voting members, a figure which includes 100 United States senators, senators and 435 List of current members of the United States House of Representatives, representatives; the House of Representatives has 6 additional Non-voting members of the United States House of Representatives, non-voting members. The vice president of the United States, as President of the Senate, has a vote in the Senate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Route Of Administration
In pharmacology and toxicology, a route of administration is the way by which a medication, drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral administration, oral and intravenous therapy, intravenous administration. Routes can also be classified based on where the target of action is. Action may be topical medication, topical (local), enteral administration, enteral (system-wide effect, but delivered through the gastrointestinal tract), or #Parenteral, parenteral (systemic action, but is delivered by routes other than the GI tract). Route of administration and dosage form are aspects of drug delivery. Classification Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
