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Raymond J. Deshaies
Raymond Joseph Deshaies (born September 25, 1961) is an American biochemist and cell biologist. He is senior vice president of global research at Amgen and a visiting associate at the California Institute of Technology (Caltech). Prior to that, he was a professor of biology at Caltech and an investigator of the Howard Hughes Medical Institute. He is also the co-founder of the biotechnology companies Proteolix and Cleave Biosciences. His research focuses on mechanisms and regulation of protein homeostasis in eukaryotic cells, with a particular focus on how proteins are conjugated with ubiquitin and degraded by the proteasome. Biography Deshaies was born in Waterbury, Connecticut, on September 25, 1961. He graduated from Cornell University with a B.S. in biochemistry in 1983. He received his biochemistry doctorate from the University of California, Berkeley, in 1988 under the direction of Randy Schekman. He performed postdoctoral studies at Berkeley (1988–1990) and subseq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Waterbury, Connecticut
Waterbury is a city in the U.S. state of Connecticut. Waterbury had a population of 114,403 as of the 2020 United States census, 2020 Census. The city is southwest of Hartford, Connecticut, Hartford and northeast of New York City. Waterbury is the largest city in the Naugatuck Valley Planning Region, Connecticut, Naugatuck Valley Planning Region and second-largest city in New Haven County, Connecticut, New Haven County. Throughout the first half of the 20th century, Waterbury had large industrial interests and was the leading center in the United States for the manufacture of brassware (including castings and finishings), as reflected in the nickname the "Brass City" and the city's motto ''Quid Aere Perennius?'' ("What Is More Lasting Than Brass?"). It was also noted for the manufacture of watches and clocks (Timex Group USA, Timex). The city is alongside Interstate 84 (Pennsylvania–Massachusetts), Interstate 84 (Yankee Expressway) and Connecticut Route 8, Route 8 and has a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sec61
Sec61, termed SecYEG in prokaryotes, is a membrane protein complex found in all domains of life. As the core component of the translocon, it transports proteins to the endoplasmic reticulum in eukaryotes and out of the cell in prokaryotes. It is a doughnut-shaped pore through the membrane with 3 different subunits (heterotrimeric), SecY (α), SecE (γ), and SecG (β). It has a region called the plug that blocks transport into or out of the ER. This plug is displaced when the hydrophobic region of a nascent polypeptide interacts with another region of Sec61 called the seam, allowing translocation of the polypeptide into the ER lumen. Although SecY and SecE are conserved in all three domains of life, bacterial SecG is only weakly homologous with eukaryotic Sec61β. The eukaryotic Sec61β is however homologous to the archaeal "SecG", leading some authors to refer to the archaeal complex as SecYEβ instead of SecYEG. (All three components of the archaeal complex are closer to their euka ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California Institute Of Technology Faculty
The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes of technology in the United States that are devoted to the instruction of pure and applied sciences. The institution was founded as a preparatory and vocational school by Amos G. Throop in 1891 and began attracting influential scientists such as George Ellery Hale, Arthur Amos Noyes, and Robert Andrews Millikan in the early 20th century. The vocational and preparatory schools were disbanded and spun off in 1910, and the college assumed its present name in 1920. In 1934, Caltech was elected to the Association of American Universities, and the antecedents of NASA's Jet Propulsion Laboratory, which Caltech continues to manage and operate, were established between 1936 and 1943 under Theodore von Kármán. Caltech has six academic divisio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Arts And Sciences
The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other Founding Fathers of the United States. It is headquartered in Cambridge, Massachusetts. Membership in the academy is achieved through a nominating petition, review, and election process. The academy's quarterly journal, '' Dædalus'', is published by the MIT Press on behalf of the academy, and has been open-access since January 2021. The academy also conducts multidisciplinary public policy research. Laurie L. Patton has served as President of the Academy since January 2025. History The Academy was established by the Massachusetts legislature on May 4, 1780, charted in order "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The sixty-tw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Member of the National Academy of Sciences, Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society Of Cell Biology
The American Society for Cell Biology (ASCB) is a professional society that was founded in 1960.American Society for Cell Biology records - Historical Note , Albin O. Kuhn Library & Gallery, . Accessed February 28, 2011. History On 6 April 1959 the passed a resolution for the establishment of a "national society ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Craig M
Craig may refer to: People and fictional characters *Craig (surname), including a list of people and fictional characters *Craig (given name), including a list of people and fictional characters *Clan Craig, a Scottish clan Places United States *Craig, Alaska, a city *Craig, Colorado, a city *Craig, Iowa, a city *Craig, Missouri, a city *Craig, Montana, an unincorporated place *Craig, Nebraska, a village *Craig, Ohio, an unincorporated community *Craig County, Oklahoma *Craig County, Virginia *Craig Township, Switzerland County, Indiana *Craig Township, Burt County, Nebraska *Mount Craig (Colorado) *Mount Craig (North Carolina) *Craig Mountain, Oregon *Craig Field (airport), a public airport near Selma, Alabama, formerly: **Craig Air Force Base, a former United States Air Force base *Craig Hospital, a neurorehabilitation and research hospital in Englewood, Colorado, United States *Fort Craig, a United States Army fort in New Mexico *The Craig School, an independent, private coedu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NEDD8
NEDD8 is a protein that in humans is encoded by the ''NEDD8'' gene. (in ''Saccharomyces cerevisiae'' this protein is known as Rub1) This ubiquitin-like protein, ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The primary known substrates of NEDD8 modification are the cullin subunits of cullin-based E3 ubiquitin ligases, which are active only when NEDDylated. Their NEDDylation is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. Activation and conjugation As with ubiquitin and SUMO, NEDD8 is conjugated to cellular proteins after its C-terminal tail is processed. The NEDD8 activating E1 enzyme is a heterodimer composed of APPBP1 and UBA3 subunits. The APPBP1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PSMD14
26S proteasome non-ATPase regulatory subunit 14, also known as 26S proteasome non-ATPase subunit Rpn11, is an enzyme that in humans is encoded by the ''PSMD14'' gene. This protein is one of the 19 essential subunits of the complete assembled 19S proteasome complex. Nine subunits Rpn3, Rpn5, Rpn6, Rpn7, Rpn8, Rpn9, Rpn11, SEM1 (yeast analogue for human protein DSS1), and Rpn12 form the lid sub complex of the 19S regulatory particle of the proteasome complex. Gene The gene ''PSMD14'' encodes one of 26S proteasome non-ATPase subunit. The human gene ''PSMD14'' has 12 Exons and locates at chromosome band 2q24.2. Protein The human protein 26S proteasome non-ATPase regulatory subunit 14 is 34.6 kDa in size and composed of 310 amino acids. The calculated theoretical pI of this protein is 6.06. Complex assembly The 26S proteasome complex usually consists of a 20S core particle (CP, or 20S proteasome) and one or two 19S regulatory particles (RP, or 19S proteasome) on eith ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CAND1
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the ''CAND1'' gene. Interactions CAND1 has been shown to interact with: * CUL1, * CUL2, * CUL3, * CUL4A, * CUL4B, * DCUN1D1, and * RBX1 RING-box protein 1 is a protein that in humans is encoded by the ''RBX1'' gene. Function This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by hete .... References External links * Further reading * * * * * * * * * * {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COP9 Signalosome
The 2003 United Nations Climate Change Conference took place between 1–12 December 2003 in Milan, Italy. The conference included the 9th Conference of the Parties (COP9) to the United Nations Framework Convention on Climate Change (UNFCCC). The parties agreed to use the Adaptation Fund established at COP7 in 2001 primarily in supporting developing countries better adapt to climate change. The fund would also be used for capacity-building through technology transfer. At the conference, the parties also agreed to review the first national reports submitted by 110 non-Annex I countries. References 21st-century diplomatic conferences Diplomatic conferences in Italy 2003 2003 2003 was designated by the United Nations as the International Year of Fresh water, Freshwater. In 2003, a Multi-National Force – Iraq, United States-led coalition 2003 invasion of Iraq, invaded Iraq, starting the Iraq War. Demographic ... 2003 in international relations 2003 in the env ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cullin
Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form ''Cullin-RING ubiquitin ligases'' (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination. The human genome contains eight cullin genes * CUL1, part of SCF complex * CUL2, part of ECS complex ( Elongin C - CUL2 - SOCS-box) * CUL3, part of CUL3-BTB complex * CUL4A * CUL4B * CUL5 * CUL7 * CUL9, also known as PARC There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex. CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin ligases Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and functi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
