RBM10
RNA-binding motif 10 is a protein that is encoded by the RBM10 gene. This gene maps on the X chromosome at Xp11.23 in humans. RBM10 is a regulator of alternative splicing. Alternative splicing is a process associated with gene expression to produce multiple protein isoforms from a single gene, thereby creating functional diversity and cellular complexity. RBM10 influences the expression of many genes, participating in various cellular processes and pathways such as cell proliferation and apoptosis. Its mutations are associated with various human diseases such as TARP syndrome, an X-linked congenital disorder in males resulting in pre‐ or postnatal lethality, and various cancers in adults. Gene and protein The RBM10 gene spans ~41.6 kb and contains 24 exons. This gene is subjected to X-inactivation, in which one of the two RBM10 genes in female cells is transcriptionally silenced by heterochromatin formation. RBM proteins constitute a large family of RNA-binding proteins (RBP ...
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