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R. Ellen Magenis
Ruth Ellen Magenis (September 24, 1925 – February 4, 2014) was an American pediatrician, medical geneticist and cytogeneticist. She was born in Gary, Indiana and received her BA in zoology from Indiana University in Bloomington, Indiana in 1948 and her MD degree from the Indiana University School of Medicine in Indianapolis in 1952. She took a number of years off to raise a large family of 6 children. She then returned to work in 1965–66 with Frederick Hecht in pediatrics and medical genetics at the University of Oregon Medical School, now called the Oregon Health & Science University (OHSU), in Portland where Magenis subsequently completed her residency training in Pediatrics and then did a postdoctoral fellowship in Medical Genetics. Magenis's first major research project involved a heritable fragile site on the long (q) arm of chromosome 16. She traced this 16q fragile site through a multigenerational family and, together with Hecht and Everett Lovrien, she linked the 16q ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gary, Indiana
Gary ( ) is a city in Lake County, Indiana, United States. The population was 69,093 at the 2020 United States census, 2020 census, making it Indiana's List of municipalities in Indiana, eleventh-most populous city. The city has been historically dominated by major industrial activity and is home to U.S. Steel's Gary Works, the largest steel mill complex in North America. Gary is located along the southern shore of Lake Michigan about southeast of Chicago Loop, downtown Chicago. The city is the western gateway to the Indiana Dunes National Park, and is within the Chicago metropolitan area. Gary was named after lawyer Elbert Henry Gary, who was the founding chairman of the United States Steel Corporation. U.S. Steel had established the city in 1906 as a company town to serve its steel mills. Like other Rust Belt cities, Gary's once thriving steel industry has been significantly affected by the disappearance of local manufacturing jobs since the 1970s. As a result of this economi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haptoglobin
Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the ''HP'' gene. In blood plasma, haptoglobin binds with high affinity to ''free'' hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to ''free'' heme. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels. The protein was discovered as a "plasma substance" in 1938 by French biochemists Max-Fernand Jayle and Michel Polonovski. Function Hemoglobin that has been released into the blood plasma by damaged red blood cells has harmful effects. The ''HP'' gene encodes a preproprotein that is proc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oregon Health & Science University Faculty
Oregon ( , ) is a state in the Pacific Northwest region of the United States. It is a part of the Western U.S., with the Columbia River delineating much of Oregon's northern boundary with Washington, while the Snake River delineates much of its eastern boundary with Idaho. The 42° north parallel delineates the southern boundary with California and Nevada. The western boundary is formed by the Pacific Ocean. Oregon has been home to many indigenous nations for thousands of years. The first European traders, explorers, and settlers began exploring what is now Oregon's Pacific coast in the early to mid-16th century. As early as 1564, the Spanish began sending vessels northeast from the Philippines, riding the Kuroshio Current in a sweeping circular route across the northern part of the Pacific. In 1592, Juan de Fuca undertook detailed mapping and studies of ocean currents in the Pacific Northwest, including the Oregon coast as well as the strait now bearing his name. The Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indiana University School Of Medicine Alumni
Indiana ( ) is a state in the Midwestern region of the United States. It borders Lake Michigan to the northwest, Michigan to the north and northeast, Ohio to the east, the Ohio River and Kentucky to the south and southeast, and the Wabash River and Illinois to the west. Nicknamed "the Hoosier State", Indiana is the 38th-largest by area and the 17th-most populous of the 50 states. Its capital and largest city is Indianapolis. Indiana was admitted to the Union as the 19th state on December 11, 1816. Indigenous resistance to American settlement was broken with defeat of the Tecumseh's confederacy in 1813. The new settlers were primarily Americans of British ancestry from the eastern seaboard and the Upland South, and Germans. After the Civil War, in which the state fought for the Union, natural gas attracted heavy industry and new European immigrants to its northern counties. In the first half of the 20th century, northern and central sections experienced a boom in goods m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Geneticists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University The American University (AU or A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Geneticists
Medicine is the science and practice of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of creativity and skill), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Pediatricians
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1925 Births
Events January * January 1 – The Syrian Federation is officially dissolved, the State of Aleppo and the State of Damascus having been replaced by the State of Syria (1925–1930), State of Syria. * January 3 – Benito Mussolini makes a pivotal speech in the Italian Chamber of Deputies (Italy), Chamber of Deputies which will be regarded by historians as the beginning of his dictatorship. * January 5 – Nellie Tayloe Ross becomes the first female governor (Wyoming) in the United States. Twelve days later, Ma Ferguson becomes first female governor of Texas. * January 25 – Hjalmar Branting resigns as Prime Minister of Sweden because of ill health, and is replaced by the minister of trade, Rickard Sandler. * January 27–February 1 – The 1925 serum run to Nome (the "Great Race of Mercy") relays diphtheria antitoxin by dog sled across the U.S. Territory of Alaska to combat an epidemic. February * February 25 – Art Gillham records (for Columbia Re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'' is the peer review, peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' cover the full range of List of academ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smith–Magenis Syndrome
Smith–Magenis syndrome (SMS), also known as 17p-microdeletion syndrome, is a microdeletion syndrome characterized by an abnormality in the short (p) arm of chromosome 17. It has features including intellectual disability, facial abnormalities, difficulty sleeping, and numerous behavioral problems such as self-harm. Smith–Magenis syndrome affects an estimated between 1 in 15,000 to 1 in 25,000 individuals. Signs and symptoms Facial features of children with Smith–Magenis syndrome include a broad and square face, deep-set eyes, large cheeks, and a prominent jaw, as well as a flat nose bridge (in the young child; as the child ages it becomes more ski-jump shaped). Eyes tend to be deep-set, close together, and slanted upwards. Eyebrows are heavy with lateral extension. The mouth is the most noticeable feature; both upper and lower lips are full, and the mouth is wide. The mouth curves downwards and the upper lip curves outwards, due to a fleshy philtrum. These facial features b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It was the world's largest collaborative biological project. Planning for the project began in 1984 by the US government, and it officially launched in 1990. It was declared complete on 14 April 2003, and included about 92% of the genome. Level "complete genome" was achieved in May 2021, with only 0.3% of the bases covered by potential issues. The final gapless assembly was finished in January 2022. Funding came from the US government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside the government by the Celera Corporation, or Celera Genomics, which was formall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
