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Protoanemonin
Protoanemonin (sometimes called anemonol or ranunculol) is a toxin whose glyosidic precursor ranunculin is found in many plants of the buttercup family (Ranunculaceae). When the plant is wounded or macerated, ranunculin is enzymatically broken down into glucose and protoanemonin. This toxin's ability to inhibit both gram positive and gram negative bacteria is linked to the presence of a 5-membered lactone ring with a highly reactive double bond system. Biological pathway Toxicity Protoamenonin has vesicant properties, which cause rashes or blistering upon contact with the skin or mucosa. Ingesting large amounts of the toxin despite its bitter taste can cause nausea, vomiting, dizziness, spasms, acute hepatitis, jaundice, or paralysis in animals and humans. Safety At room temperature, protoanemonin spontaneously dimerizes into the potentially therapeutic compound anemonin, which can then be hydrolyzed into a dicarboxylic acid. As such, plants containing glycosidic precursors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anemonin
Anemonin is a dibutenolide natural product found in members of the buttercup family (Ranunculaceae) such as ''Helleborus niger'', ''Ranunculus bulbosus'', ''Ranunculus ficaria, R. ficaria'', ''Ranunculus sardous, R. sardous'', ''Ranunculus sceleratus, R. sceleratus'', and ''Clematis hirsutissima''. Originally isolated in 1792 by M. Heyer, It is the Dimer (chemistry), dimerization product of the toxin protoanemonin. One of the likely active agents in plants used in Chinese medicine as an anti-inflammatory and Native American medicine as a horse stimulant, its unique biological properties give it pharmaceutical potential as an anti-inflammatory agent. Biosynthetic origins Anemonin is a Dimer (chemistry), homodimer formed from two protoanemonin subunits. Protoanemonin is formed from the enzymatic cleavage of ranunculin upon crushing plant matter. When a plant from this family is injured, a β-glucosidase cleaves ranunculin, liberating protoanemonin from glucose as a defense mechanis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ranunculin Skeletal
Ranunculin is a glycoside found in many members of the buttercup family, including species of Helleborus, Anemone, Clematis and most commonly Ranunculus. Glycosides are common in plants, where they serve as defense mechanisms against herbivores and microorganisms. When plant cell wall structures are damaged, glycosidase enzymes hydrolyze the inactive glycoside into its components- a sugar and practically any other molecule, which is called the aglycone. Ranunculin is a glucoside, which indicates that glucose is the specific sugar attached its aglycone protoanemonin. Toxicity Ranunculin is very stable in acidic medium and fresh plant tissues, but in alkaline solution or damaged plant cells is hydrolyzed into the unstable toxin protoanemonin Protoanemonin (sometimes called anemonol or ranunculol) is a toxin whose glyosidic precursor ranunculin is found in many plants of the buttercup family (Ranunculaceae). When the plant is wounded or macerated, ranunculin is enzymatically ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ranunculin
Ranunculin is a glycoside found in many members of the Ranunculaceae, buttercup family, including species of Helleborus, Anemone, Clematis and most commonly Ranunculus. Glycosides are common in plants, where they serve as defense mechanisms against herbivores and microorganisms. When plant cell wall structures are damaged, glycosidase enzymes hydrolyze the inactive glycoside into its components- a sugar and practically any other molecule, which is called the aglycone. Ranunculin is a glucoside, which indicates that glucose is the specific sugar attached its aglycone protoanemonin. Toxicity Ranunculin is very stable in acidic medium and fresh plant tissues, but in alkaline solution or damaged plant cells is hydrolyzed into the unstable toxin protoanemonin and glucose. Protoanemonin release References {{reflist, refs= {{cite journal , last1=Bai , first1=Yili , last2=Benn , first2=Michael , last3=Majak , first3=Walter , last4=McDiamid , first4=Ruth , title=Extraction and HPLC ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buttercup Family
Ranunculaceae (, buttercup or crowfoot family; Latin "little frog", from "frog") is a family of over 2,000 known species of flowering plants in 43 genera, distributed worldwide. The largest genera are ''Ranunculus'' (600 species), ''Delphinium'' (365), ''Thalictrum'' (330), ''Clematis'' (380), and ''Aconitum'' (300). Description Ranunculaceae are mostly herbaceous annuals or perennials, but some are woody climbers (such as ''Clematis'') or shrubs (e.g. ''Xanthorhiza''). Most members of the family have bisexual flowers which can be showy or inconspicuous. Flowers are solitary, but are also found aggregated in cymes, panicles, or spikes. The flowers are usually radially symmetrical but are also found to be bilaterally symmetrical in the genera ''Aconitum'' and ''Delphinium''. The sepals, petals, stamens and carpels are all generally free (not fused), the outer flower segments typically number four or five. The outer stamens may be modified to produce only nectar, as in Aquile ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nausea
Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. It can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the throat. Over 30 definitions of nausea were proposed in a 2011 book on the topic. Nausea is a non-specific symptom, which means that it has many possible causes. Some common causes of nausea are gastroenteritis and other gastrointestinal disorders, food poisoning, motion sickness, dizziness, migraine, fainting, low blood sugar, anxiety, hyperthermia, dehydration and lack of sleep. Nausea is a side effect of many medications including chemotherapy, or morning sickness in early pregnancy. Nausea may also be caused by disgust and depression. Medications taken to prevent and treat nausea and vomiting are called antiemetics. The most commonly prescribed antiemetics in the US are promethazine, metoclopramide, and the newer ondansetron. The word na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dizziness
Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness. It can also refer to Balance disorder, disequilibrium or a non-specific feeling, such as giddiness or foolishness. Dizziness is a common medical complaint, affecting 20–30% of persons. Dizziness is broken down into four main subtypes: vertigo (~25–50%), equilibrioception#Dysfunction, disequilibrium (less than ~15%), presyncope (less than ~15%), and nonspecific dizziness (~10%). * Vertigo is the sensation of spinning or having one's surroundings spin about them. Many people find vertigo very disturbing and often report associated nausea and vomiting. * Presyncope describes lightheadedness or feeling faint; the name relates to Syncope (medicine), syncope, which is actually fainting. * equilibrioception#Dysfunction, Disequilibrium is the sensation of being off balance and is most often characterized by frequent falls in a specific direction. This condition is not of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spasm
A spasm is a sudden involuntary contraction of a muscle, a group of muscles, or a hollow organ, such as the bladder. A spasmodic muscle contraction may be caused by many medical conditions, including dystonia. Most commonly, it is a muscle cramp which is accompanied by a sudden burst of pain. A muscle cramp is usually harmless and ceases after a few minutes. It is typically caused by ion imbalance or muscle fatigue. There are other causes of involuntary muscle contractions, and some of these may cause a health problem. A series of spasms, or permanent spasms, is referred to as a "spasmism". Description and causes Spasms occur when the part of the brain that controls movement malfunctions, causing involuntary muscle activity. A spasm may be a muscle contraction caused by abnormal nerve stimulation or by abnormal activity of the muscle itself. Causes The cause of spasms is often unknown, but it can be due to an inherited genetic problem, a side effect of medicatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatitis
Hepatitis is inflammation of the liver parenchyma, liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), Anorexia (symptom), poor appetite, vomiting, fatigue (medicine), tiredness, abdominal pain, and diarrhea. Hepatitis is ''acute (medicine), acute'' if it resolves within six months, and ''chronic condition, chronic'' if it lasts longer than six months. Acute hepatitis can self-limiting (biology), resolve on its own, progress to chronic hepatitis, or (rarely) result in acute liver failure. Chronic hepatitis may progress to scarring of the liver (cirrhosis), liver failure, and liver cancer. Hepatitis is most commonly caused by the virus ''hepatovirus A'', ''hepatitis B virus, B'', ''hepatitis C virus, C'', ''hepatitis D virus, D'', and ''hepatitis E virus, E''. Other Viral hepatitis, viruses can also cause liver inflammation, including cytomegalovirus, Epstein–Barr virus, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paralysis
Paralysis (: paralyses; also known as plegia) is a loss of Motor skill, motor function in one or more Skeletal muscle, muscles. Paralysis can also be accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage. In the United States, roughly 1 in 50 people have been diagnosed with some form of permanent or transient paralysis. The word "paralysis" derives from the Greek language, Greek παράλυσις, meaning "disabling of the nerves" from παρά (''para'') meaning "beside, by" and λύσις (''lysis'') meaning "making loose". A paralysis accompanied by involuntary tremors is usually called "palsy". Causes Paralysis is most often caused by damage in the nervous system, especially the spinal cord. Other major causes are stroke, Physical trauma, trauma with nerve injury, poliomyelitis, cerebral palsy, peripheral neuropathy, Parkinson's disease, ALS, botulism, spina bifida, multiple sclerosis and Guillain–Barré syndrome. Incidents th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jaundice
Jaundice, also known as icterus, is a yellowish or, less frequently, greenish pigmentation of the skin and sclera due to high bilirubin levels. Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. The prevalence of jaundice in adults is rare, while jaundice in babies is common, with an estimated 80% affected during their first week of life. The most commonly associated symptoms of jaundice are itchiness, pale feces, and dark urine. Normal levels of bilirubin in blood are below 1.0 mg/ dl (17 μmol/ L), while levels over 2–3 mg/dl (34–51 μmol/L) typically result in jaundice. High blood bilirubin is divided into two types: unconjugated and conjugated bilirubin. Causes of jaundice vary from relatively benign to potentially fatal. High unconjugated bilirubin may be due to excess red blood cell breakdown, large bruises, gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vesicant
A blister agent (or vesicant) is a chemical compound that causes severe skin, eye and mucosal pain and irritation in the form of severe chemical burns resulting in fluid filled blisters. Named for their ability to cause vesication, blister agent refers in common parlance to those agents which are developed for, or have been in the past utilized as chemical weapons, though some naturally occurring substances such as cantharidin fall under the same terminology.Cantharidin and Meloids: a review of classical history, biosynthesis, and function Exposure to blister agents is widely incapacitating, but often precipitates a delayed effect, with symptoms developing one to twenty four hours following the initial contact with the agent. Tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
