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Proteus Vulgaris
''Proteus vulgaris'' is a rod-shaped, nitrate-reducing, indole-positive and catalase-positive, hydrogen sulfide-producing, Gram-negative bacterium that inhabits the intestinal tracts of humans and animals. It can be found in soil, water, and fecal matter. It is grouped with the Morganellaceae and is an opportunistic pathogen of humans. It is known to cause wound infections and other species of its genera are known to cause urinary tract infections. ''P. vulgaris'' was one of the three species Hauser isolated from putrefied meat and identified (1885). Over the past two decades, the genus ''Proteus'', and in particular ''P. vulgaris'', has undergone a number of major taxonomic revisions. In 1982, ''P. vulgaris'' was separated into three biogroups on the basis of indole production. Biogroup one was indole negative and represented a new species, ''P. penneri'', while biogroups two and three remained together as ''P. vulgaris''. Lab identification According to laborator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gustav Hauser
Gustav Hauser (13 July 1856 in Nördlingen – 30 June 1935 in Erlangen) was a German pathologist and bacteriologist. He studied medicine at the Universities of Munich and Erlangen, where he worked as an assistant in the gynecological clinic under Paul Zweifel and at the pathological institute of Friedrich Albert von Zenker. In 1883 he obtained his habilitation for pathological anatomy and bacteriology, and in 1895 became a full professor and director of the institute of pathology in Erlangen. In 1885, Hauser was the first to isolate the bacillus ''Proteus vulgaris''. He is also credited with developing a formalin for the preservation of bacterial cultures. In Erlangen, the thoroughfare ''Gustav-Hauser-Straße'' is named in his honor. Published works He was the author of works on numerous subjects in medicine. In the field of entomology, he was the author of ''Die Damaster-Coptolabrus-Gruppe der Gattung Carabus'' (The Damaster-Coptolabrus group and the genus '' Carabus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasmid
A plasmid is a small, extrachromosomal DNA molecule within a cell that is physically separated from chromosomal DNA and can replicate independently. They are most commonly found as small circular, double-stranded DNA molecules in bacteria and archaea; however plasmids are sometimes present in and eukaryotic organisms as well. Plasmids often carry useful genes, such as those involved in antibiotic resistance, virulence, secondary metabolism and bioremediation. While chromosomes are large and contain all the essential genetic information for living under normal conditions, plasmids are usually very small and contain additional genes for special circumstances. Artificial plasmids are widely used as vectors in molecular cloning, serving to drive the replication of recombinant DNA sequences within host organisms. In the laboratory, plasmids may be introduced into a cell via transformation. Synthetic plasmids are available for procurement over the internet by various vendors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enterobacterales
Enterobacterales is an order of Gram-negative bacteria, Gram-negative, non-spore forming, Facultative anaerobic organism, facultatively anaerobic, rod-shaped bacteria with the class Gammaproteobacteria. The type genus of this order is ''Enterobacter.'' The name Enterobacterales is derived from the Latin term ''Enterobacter'', referring the type genus of the order and the suffix "-ales", an ending used to denote an order. Together, Enterobacterales refers to an order whose nomenclatural type is the genus ''Enterobacter''. Historical Identification and Systematics Enterobacterales was proposed in 2005 under the name "Enterobacteriales". However, the name "Enterobacteriales" was not validated according to the rules of the ''International Code of Nomenclature of Prokaryotes,'' thus it lacked standing in nomenclature, so the name was written in parentheses. "Enterobacteriales" was a monotypic order, containing only the family ''Enterobacteriaceae'', and shared its type genus ''Esch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swarming Motility
Swarming motility is a rapid (2–10 μm/s) and coordinated translocation of a bacterial population across solid or semi-solid surfaces, and is an example of bacterial multicellularity and swarm behaviour. Swarming motility was first reported by Jorgen Henrichsen and has been mostly studied in genus ''Serratia'', ''Salmonella'', ''Aeromonas'', ''Bacillus'', ''Yersinia'', ''Pseudomonas'', ''Proteus (bacterium), Proteus'', ''Vibrio'' and ''Escherichia''. This multicellular behavior has been mostly observed in controlled laboratory conditions and relies on two critical elements: 1) the nutrient composition and 2) viscosity of culture medium (i.e. % agar). One particular feature of this type of motility is the formation of dendritic fractal-like patterns formed by migrating swarms moving away from an initial location. Although the majority of species can produce tendrils when swarming, some species like ''Proteus mirabilis'' do form concentric circles motif instead of dendritic patter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteus OX19
''Proteus'' OX19 is a strain of the ''Proteus vulgaris'' bacterium. History In 1915, Arthur Felix and Edward Weil discovered that ''Proteus'' OX19 reacted to the same human immune antibodies as typhus. Other ''Proteus'' strains were similarly used to create reagents for other rickettsiae diseases, thus resulting in the commercial Weil-Felix antibody-agglutination test. Use in fake epidemic in Poland Drs. Eugeniusz Lazowski and his medical-school friend Stanisław Matulewicz were practicing in the small town of Rozwadów in Poland during World War II. Dr. Matulewicz realized that since ''Proteus vulgaris'' strain OX19 was used to manufacture the then-common Weil-Felix antibody-agglutination test for typhus Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposu ..., inoculating vi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ampicillin/sulbactam
Ampicillin/sulbactam is a fixed-dose combination medication of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase. Two different forms of the drug exist. The first, developed in 1987 and marketed in the United States under the brand name Unasyn, generic only outside the United States, is an intravenous antibiotic. The second, an oral form called sultamicillin, is marketed under the brand name Ampictam outside the United States, and generic only in the United States. Ampicillin/sulbactam is used to treat infections caused by bacteria resistant to beta-lactam antibiotics. Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria. Medical uses Ampicillin/sulbactam has a wide array of medical use for many different types of infectious disease. It is usually reserved as a second-line therapy in cases where bacteria have become beta-lactamase resistant, rendering t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Piperacillin/tazobactam
Piperacillin/tazobactam, sold under the brand name Tazocin among others, is a combination medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam. The combination has activity against many Gram-positive and Gram-negative bacteria including ''Pseudomonas aeruginosa''. It is used to treat pelvic inflammatory disease, intra-abdominal infection, pneumonia, cellulitis, and sepsis. It is given by injection into a vein. Common adverse effects include headache, trouble sleeping, rash, nausea, constipation, and diarrhea. Serious adverse effects include ''Clostridioides difficile'' infection and allergic reactions including anaphylaxis. Those who are allergic to other β-lactam are more likely to be allergic to piperacillin/tazobactam. Use in pregnancy or breastfeeding appears to generally be safe. It usually results in bacterial death through blocking their ability to make a cell wall. Piperacillin/tazobactam was approved for medical use in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meropenem
Meropenem, sold under the brand name Merrem among others, is an intravenous carbapenem antibiotic used to treat a variety of bacterial infections. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Serious side effects include ''Clostridioides difficile'' infection, seizures, and allergic reactions including anaphylaxis. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Use in pregnancy appears to be safe. It is in the carbapenem family of medications. Meropenem usually results in bacterial death through blocking their ability to make a cell wall. It is resistant to breakdown by many kinds of β-lactamase enzymes, produced by bacteria to protect themselves from antibiotics. Meropenem was patented in 1983. It was approved for medical use in the United States in 1996. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cefoperazone
Cefoperazone is a third-generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid. It is one of few cephalosporin antibiotics effective in treating ''Pseudomonas'' bacterial infections which are otherwise resistant to these antibiotics. It was patented in 1974 and approved for medical use in 1981. Cefoperazone/sulbactam (Sulperazon) is a co-formulation with sulbactam. Spectrum of bacterial susceptibility Cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract. The following represents MIC susceptibility data for a few medically significant microorganisms. * ''Haemophilus influenzae'': 0.12 - 0.25 μg/ml * ''Staphylococcus aureus'': 0.125 - 32 μg/ml * ''Streptococcus pneumoniae'': ≤0.007 - 1 μg/ml Adverse effects Cefoperazone contains an ''N''-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibioti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulbactam
Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...s. It was patented in 1977 and approved for medical use in 1986. Medical uses The combination ampicillin/sulbactam (Unasyn) is available in the United States. The combination cefoperazone/sulbactam (Sulperazon) is available in many countries but not in the United States. The co-packaged combination sulbactam/durlobactam was approved for medical use in the United States in May 2023. Mechanism Sulbactam is primarily used as a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin. Sulbactam itself contains a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netilmicin
Netilmicin (1-''N''-ethylsisomicin) is a semisynthetic aminoglycoside antibiotic, and a derivative of sisomicin, produced by '' Micromonospora inyoensis''. Aminoglycoside antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. It was patented in 1973 and approved for medical use in 1981. It was approved for medical use in the UK in December 2019, for the treatment of external infections of the eye. It is on the World Health Organization's List of Essential Medicines. __TOC__ Comparison with drugs According to the British National Formulary (BNF), netilmicin has similar activity to gentamicin, but less ototoxicity in those needing treatment for longer than 10 days. Netilmicin is active against a number of gentamicin-resistant Gram-negative bacteria but is less active against '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ceftazidime
Ceftazidime, sold under the brand name Fortaz among others, is a third-generation cephalosporin antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for joint infections, meningitis, pneumonia, sepsis, urinary tract infections, malignant otitis externa, ''Pseudomonas aeruginosa'' infection, and vibrio infection. It is given by injection into a vein, muscle, or eye. Common side effects include nausea, allergic reactions, and pain at the site of injection. Other side effects may include ''Clostridioides difficile'' diarrhea. It is not recommended in people who have had previous anaphylaxis to a penicillin. Its use is relatively safe during pregnancy and breastfeeding. It is in the third-generation cephalosporin family of medications and works by interfering with the bacteria's cell wall. Ceftazidime was patented in 1978 and came into commercial use in 1984. It is on the World Health Organization's List of Essential Medicines. Ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
