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Prostate Cancer Foundation
The Prostate Cancer Foundation (PCF), headquartered in Santa Monica, California, funds research into the prevention and cure of prostate cancer. Several important prostate cancer discoveries made in the past 30 years have been as a result of PCF's actions, whether in funding or in coordination. These results include the development of new medications, gene therapy approaches, and the development of vaccines that signal the body's immune system to kill cancer cells. In 2017, 81% of every dollar spent goes to the prostate cancer research mission. Since 2007, more than $52.8 million has been awarded to the Young Investigator Program, a PCF program that gives recent MDs and PhDs the opportunity to conduct pivotal research at a critical point early in their careers as research scientists. In 2017, the PCF Global Research Enterprise supported teamwork and team science with a portfolio that included 372 active research awards totaling $118 million. There are 220 active Challenge Award ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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PCF may refer to: 1+3 Computing * ''PC Format'', a monthly magazine * Percentage-closer filtering, a shadow mapping technique in computer graphics * Pivotal Cloud Foundry, a version of the open source Cloud Foundry software supported by Pivotal Software * Point coordination function, a media access control technique used in wireless LANs * Pair correlation function, a statistical tool to measure spatial correlation * Polymer-clad fiber, a type of optical fiber * Programming Computable Functions, a functional programming language File formats * Physical Constraints File, a file format for the specification of FPGA * Portable Compiled Format, a file format for distributing bitmap fonts * Portable Content Format, a file format for DVB-based interactive television * Profile Configuration File, a configuration file used to set up VPN connections * Page configuration Format (Guidewire) Technology * Photonic-crystal fiber * Pounds per cubic foot, a non- SI unit for density * Piv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Denosumab
Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs. Denosumab is a inhibitor of RANKL (receptor activator of nuclear factor kappa-Β ligand), which works by preventing the development of osteoclasts, which are cells that break down bone. It was developed by the biotechnology company Amgen. Medical uses Denosumab is used for those with osteoporosis at high risk for fractures, bone loss due to certain medications, and in those with bone metastases. Cancer A 2012 meta-analysis found that denosumab was better than placebo, zoledronic acid and pamidronate, in reducing the risk of fractures in those with cancer. Osteoporosis In those with postmenopausal osteoporosis denosumab decreases the risk of f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Father's Day
Father's Day is a holiday of honoring fatherhood and paternal bonds, as well as the influence of fathers in society. In Catholic countries of Europe, it has been celebrated on 19 March as Saint Joseph's Day since the Middle Ages. In the United States, Father's Day was founded by Sonora Smart Dodd, and celebrated on the third Sunday of June for the first time in 1910. The day is held on various dates across the world, and different regions maintain their own traditions of honoring fatherhood. Father's Day is a recognized public holiday in Lithuania and some parts of Spain and was regarded as such in Italy until 1977. It is a national holiday in Estonia, Samoa, and equivalently in South Korea, where it is celebrated as Parents' Day. The holiday complements similar celebrations honoring family members, such as Mother's Day, Siblings Day, and Grandparents' Day. History Early history For centuries, the Eastern Orthodox Church has appointed the second Sunday before Nativity as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major League Baseball
Major League Baseball (MLB) is a professional baseball organization and the oldest major professional sports league in the world. MLB is composed of 30 total teams, divided equally between the National League (NL) and the American League (AL), with 29 in the United States and 1 in Canada. The NL and AL were formed in 1876 and 1901, respectively. Beginning in 1903, the two leagues signed the National Agreement and cooperated but remained legally separate entities until 2000, when they merged into a single organization led by the Commissioner of Baseball. MLB is headquartered in Midtown Manhattan. It is also included as one of the major professional sports leagues in the United States and Canada. Baseball's first all-professional team, the Cincinnati Red Stockings, was founded in 1869. Before that, some teams had secretly paid certain players. The first few decades of professional baseball were characterized by rivalries between leagues and by players who often jumped from on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HRC2015 Fullcolor
HRC or hrc may refer to: Transportation * South Atlantic Airways (ICAO airline code) * Zhayrem Airport ( IATA code), Zhayrem, Kazakhstan * Hercules station (Amtrak station code), Hercules, California, US Organizations * Harry Ransom Center, a museum, library, and archive of the University of Texas * Hellenic Red Cross, the Greek Red Cross Society * Hertford Regional College, a further education college in Hertfordshire * Honda Racing Corporation, a motorcycle racing division of the Honda Motor Company * Human Rights Campaign, an LGBT equal rights organization * Human rights commission, a body to protect human rights * United Nations Human Rights Committee, a United Nations body of 18 experts that meets three times a year for four-week sessions * United Nations Human Rights Council, a United Nations inter-governmental body that includes representation by 47 member states * United States Army Human Resources Command, a command agency for career management of United States Army an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Cancer Institute
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship. NCI is the oldest and has the largest budget and research program of the 27 institutes and centers of the NIH ($6.9 billion in 2020). It fulfills the majority of its mission via an extramural program that provides grants for cancer research. Additionally, the National Cancer Institute has intramural research programs in Bethesda, Maryland, and at the Frederick National Laboratory for Cancer Research at Fort Detrick in Frederick, Maryland. The NCI receives more than in funding eac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fortune (magazine)
''Fortune'' is an American multinational business magazine headquartered in New York City. It is published by Fortune Media Group Holdings, owned by Thai businessman Chatchaval Jiaravanon. The publication was founded by Henry Luce in 1929. The magazine competes with '' Forbes'' and '' Bloomberg Businessweek'' in the national business magazine category and distinguishes itself with long, in-depth feature articles. The magazine regularly publishes ranked lists, including the ''Fortune'' 500, a ranking of companies by revenue that it has published annually since 1955. The magazine is also known for its annual ''Fortune Investor's Guide''. History ''Fortune'' was founded by '' Time'' magazine co-founder Henry Luce in 1929 as "the Ideal Super-Class Magazine", a "distinguished and de luxe" publication "vividly portraying, interpreting and recording the Industrial Civilization". Briton Hadden, Luce's business partner, was not enthusiastic about the idea – which Luce originally ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ETS Transcription Factor Family
In the field of molecular biology, the ETS (E26 transformation-specific or E-twenty-six. (Erythroblast Transformation Specific)) family is one of the largest families of transcription factors and is unique to animals. There are 29 genes in humans, 28 in the mouse, 10 in ''Caenorhabditis elegans'' and 9 in ''Drosophila.'' The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression. Subfamilies The ETS (Erythroblast Transformation Specific)family is divided into 12 subfamilies, which are listed below: Structure All ETS (Erythroblast Transformation Specific) family members are identified through a highly conserved DNA binding domain, the ETS domain, which is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. As well as DNA-binding functions, evidence suggests that the ETS dom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteomic
Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of functional genomics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Androgen Receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen-regulated genes are critical for the development and maintenance of the male sexual phenotype. Function Effect on development In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-angiogenesis
An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels ( angiogenesis). Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet. While angiogenesis is a critical part of wound healing and other favorable processes, certain types of angiogenesis are associated with the growth of malignant tumors. Thus angiogenesis inhibitors have been closely studied for possible cancer treatment. Angiogenesis inhibitors were once thought to have potential as a " silver bullet" treatment applicable to many types of cancer, but the limitations of anti-angiogenic therapy have been shown in practice. Nonetheless, inhibitors are used to effectively treat cancer, macular degeneration in the eye, and other diseases that involve a proliferation of blood vessels. Mechanism of action When a tumor stimulates the growth of new vessels, it is said to have undergone an 'angiogeni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genotypes
The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have in a specific gene depends on the number of copies of each chromosome found in that species, also referred to as ploidy. In diploid species like humans, two full sets of chromosomes are present, meaning each individual has two alleles for any given gene. If both alleles are the same, the genotype is referred to as homozygous. If the alleles are different, the genotype is referred to as heterozygous. Genotype contributes to phenotype, the observable traits and characteristics in an individual or organism. The degree to which genotype affects phenotype depends on the trait. For example, the petal color in a pea plant is exclusively determined by genotype. The petals can be purple or white depending on the alleles present in the pea plant. Ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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