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Precision Medicine Initiative
The All of Us Research Program (previously known as the Precision Medicine Initiative Cohort Program) is a precision medicine research program created in 2015 under the Obama Administration with $130 million in funding that aims to make advances in tailoring medical care to the individual's genetics. The mission of All of Us is to accelerate health and medical breakthroughs, enabling individualized prevention, treatment and care. The project aimed to collect genetic and health data from one million volunteers, and recruited around 297,549 participants. The project says its data is analyzed by 2,300 researchers. Program The initiative was announced during the 2015 State of the Union Address, and is run by the National Institutes of Health (NIH). The program is bilingual, with information and materials available in Spanish and English. Enrollment Eligible adults (18 and over) can enroll with the program. People who are not eligible are those in prison or people who cannot con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bethesda, Maryland
Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland, United States. Located just northwest of Washington, D.C., it is a major business and government center of the Washington metropolitan region and a national center for medical research. According to the 2020 census, the community had a population of 68,056. Etymology It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which in turn took its name from Jerusalem's Pool of Bethesda. History Bethesda is located in the traditional territory of the indigenous Native Piscataway and Nacotchtank at the time of European colonization. Fur trader Henry Fleet became the first European to visit the area, reaching it by sailing up the Potomac River. He stayed with the Piscataway tribe from 1623 to 1627, either as a guest or prisoner (historical accounts differ). Fleet eventually secured funding for another expedition to the region and was later gra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19 Pandemic
The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December 2019. Soon after, it spread to other areas of Asia, and COVID-19 pandemic by country and territory, then worldwide in early 2020. The World Health Organization (WHO) declared the outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat, nocturnal cough, and fatigue. Transmission of COVID-19, Transmission of the virus is often airborne transmission, through airborne particles. Mutations have variants of SARS-CoV-2, produced many strains (variants) with varying degrees of infectivity and virulence. COVID-19 vaccines were developed rapidly and deplo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PrecisionFDA
PrecisionFDA (stylized precisionFDA) is a secure, collaborative, high-performance computing platform that has established a growing community of experts around the analysis of biological datasets in order to advance precision medicine, inform regulatory science, and enable improvements in health outcomes. This cloud-based platform is developed and served by the United States Food and Drug Administration (FDA). PrecisionFDA connects experts, citizen scientists, and scholars from around the world and provides them with a library of computational tools, workflow features, and reference data. The platform allows researchers to upload and compare data against reference genomes, and execute bioinformatic pipelines. The variant call file (VCF) comparator tool also enables users to compare their genetic test results to reference genomes. The platform's code is open source and available on GitHub. The platform also features a crowdsourcing model to sponsor community challenges in order to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Precision Medicine
Precision, precise or precisely may refer to: Arts and media * ''Precision'' (march), the official marching music of the Royal Military College of Canada * "Precision" (song), by Big Sean * ''Precisely'' (sketch), a dramatic sketch by the English playwright Harold Pinter Science, and technology, and mathematics Mathematics and computing (general) * Accuracy and precision, measurement deviation from true value and its scatter * Significant figures, the number of digits that carry real information about a measurement * Precision and recall, in information retrieval: the proportion of relevant documents returned * Precision (computer science), a measure of the detail in which a quantity is expressed * Precision (statistics), a model parameter or a quantification of precision Computing products * Dell Precision, a line of Dell workstations * Precision Architecture, former name for PA-RISC Precision Architecture reduced instruction set computer, RISC (PA-RISC) or Hewlet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Baseline Study
Project Baseline is a broad effort to map human health led by Verily Life Sciences (formerly Google Life Sciences), Alphabet, Inc.'s health sciences division, and was announced in the Wall Street Journal on July 24, 2014. It begins with the Project Baseline Study, which will collect phenotypic health data from approximately 10,000 participants over the course of at least four years. The project employs experts from widely varying fields including science, medicine, user experience and design, engineering and patient advocacy. The project is not the first one to aim to collect data on many individuals for medical purposes, but it aims to collect a much larger amount of data covering a broader array of topics than its predecessors. De-identified Project Baseline study data will be available to qualified researchers for exploratory analysis in the future. Qualified external researchers may apply through applications reviewed by the Proposal Review and Publications Committee and Scient ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st Century Cures Act
The 21st Century Cures Act is a United States law enacted by the 114th United States Congress in December 2016 and then signed into law on December 13, 2016. It authorized $6.3 billion in funding, mostly for the National Institutes of Health. The act was supported especially by large pharmaceutical manufacturers and was opposed especially by some consumer organizations. The approval of drugs and devices would be streamlined, according to supporters, and treatments would reach the market more quickly. The argument made by opponents was that it would allow the marketing of riskier or less effective treatments by allowing the approval of drugs and devices on the basis of flimsier evidence, bypassing randomized, controlled trials. The bill incorporated the Helping Families In Mental Health Crisis Act, first introduced by then-Congressman Tim Murphy, R-Pa., which increased the availability of psychiatric hospital beds and established a new assistant secretary for mental health and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
100,000 Genomes Project
The 100,000 Genomes Project is a now-completed UK Government project managed by Genomics England that is sequencing whole genomes from National Health Service patients. The project is focusing on rare diseases, some common types of cancer, and infectious diseases. Participants give consent for their genome data to be linked to information about their medical condition and health records. The medical and genomic data is shared with researchers to improve knowledge of the causes, treatment, and care of diseases. The project has received over £300 million from public and private investment. History The project was first announced by UK Prime Minister David Cameron in December 2012. The Government set up a new company Genomics England to oversee the project with the plan to focus on rare diseases, cancer, and infectious diseases announced by Health Secretary Jeremy Hunt in July 2013. The project was also made possible by the National Institute for Health and Care Research (NIHR ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Principal Components Analysis
Principal component analysis (PCA) is a Linear map, linear dimensionality reduction technique with applications in exploratory data analysis, visualization and Data Preprocessing, data preprocessing. The data is linear map, linearly transformed onto a new coordinate system such that the directions (principal components) capturing the largest variation in the data can be easily identified. The principal components of a collection of points in a real coordinate space are a sequence of p unit vectors, where the i-th vector is the direction of a line that best fits the data while being orthogonal to the first i-1 vectors. Here, a best-fitting line is defined as one that minimizes the average squared perpendicular distance, perpendicular Distance from a point to a line, distance from the points to the line. These directions (i.e., principal components) constitute an orthonormal basis in which different individual dimensions of the data are Linear correlation, linearly uncorrelated. Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Communications
''Nature Communications'' is a peer-reviewed, open access, scientific journal published by Nature Portfolio since 2010. It is a multidisciplinary journal that covers the natural sciences, including physics, chemistry, earth sciences, medicine, and biology. The journal has editorial offices in London, Berlin, New York City, and Shanghai. The founding editor-in-chief was Lesley Anson, followed by Joerg Heber, Magdalena Skipper, and Elisa De Ranieri. the editors are Nathalie Le Bot for health and clinical sciences, Stephane Larochelle for biological sciences, Enda Bergin for chemistry and biotechnology, and Prabhjot Saini for physics and earth sciences. Starting October 2014, the journal only accepted submissions from authors willing to pay an article processing charge. Until the end of 2015, part of the published submissions were only available to subscribers. In January 2016, all content became freely accessible. Starting from 2017, the journal offers a deposition ser ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nonlinear Dimensionality Reduction
Nonlinear dimensionality reduction, also known as manifold learning, is any of various related techniques that aim to project high-dimensional data, potentially existing across non-linear manifolds which cannot be adequately captured by linear decomposition methods, onto lower-dimensional latent manifolds, with the goal of either visualizing the data in the low-dimensional space, or learning the mapping (either from the high-dimensional space to the low-dimensional embedding or vice versa) itself. The techniques described below can be understood as generalizations of linear decomposition methods used for dimensionality reduction, such as singular value decomposition and principal component analysis. Applications of NLDR High dimensional data can be hard for machines to work with, requiring significant time and space for analysis. It also presents a challenge for humans, since it's hard to visualize or understand data in more than three dimensions. Reducing the dimensionality of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electronic Health Records
An electronic health record (EHR) is the systematized collection of electronically stored patient and population health information in a digital format. These records can be shared across different health care settings. Records are shared through network-connected, enterprise-wide information systems or other information networks and exchanges. EHRs may include a range of data, including demographics, medical history, medication and allergies, immunization status, laboratory test results, radiology images, vital signs, personal statistics like age and weight, and billing information. For several decades, EHRs have been touted as key to increasing quality of care. EHR combines all patients' demographics into a large pool, which assists providers in the creation of "new treatments or innovation in healthcare delivery" to improve quality outcomes in healthcare. Combining multiple types of clinical data from the system's health records has helped clinicians identify and stratify c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
YouTube 2024
YouTube is an American social media and online video sharing platform owned by Google. YouTube was founded on February 14, 2005, by Steve Chen, Chad Hurley, and Jawed Karim who were three former employees of PayPal. Headquartered in San Bruno, California, it is the second-most-visited website in the world, after Google Search. In January 2024, YouTube had more than 2.7billion monthly active users, who collectively watched more than one billion hours of videos every day. , videos were being uploaded to the platform at a rate of more than 500 hours of content per minute, and , there were approximately 14.8billion videos in total. On November 13, 2006, YouTube was purchased by Google for $1.65 billion (equivalent to $ billion in ). Google expanded YouTube's business model of generating revenue from advertisements alone, to offering paid content such as movies and exclusive content produced by and for YouTube. It also offers YouTube Premium, a paid subscription ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
