|
Polio Eradication
Polio eradication, the goal of permanent global cessation of circulation of the poliovirus and hence elimination of the poliomyelitis (polio) it causes, is the aim of a multinational public health effort begun in 1988, led by the World Health Organization (WHO), the UNICEF, United Nations Children's Fund (UNICEF) and the Rotary Foundation. These organizations, along with the U.S. Centers for Disease Control and Prevention (CDC) and The Gates Foundation, have spearheaded the campaign through the Global Polio Eradication Initiative (GPEI). Successful eradication of infectious diseases has been achieved twice before, with smallpox in humans and rinderpest in ruminants. Prevention of disease spread is accomplished by vaccination. There are two kinds of polio vaccine—oral polio vaccine (OPV), which uses Attenuated vaccine, weakened poliovirus, and Inactivated vaccine, inactivated polio vaccine (IPV), which is injected. OPV is less expensive and easier to administer, and can spr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Attenuated Vaccine
An attenuated vaccine (or a live attenuated vaccine, LAV) is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or "live"). Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. These vaccines contrast to those produced by "killing" the pathogen ( inactivated vaccine). Attenuated vaccines stimulate a strong and effective immune response that is long-lasting. In comparison to inactivated vaccines, attenuated vaccines produce a stronger and more durable immune response with a quick immunity onset. They are generally avoided in pregnancy and in patients with severe immunodeficiencies. Attenuated vaccines function by encouraging the body to create antibodies and memory immune cells in response to the specific pathogen which the vaccine protects against. Common examples of live attenuated vaccines are measles, mumps, rubella, yellow fever, varicella, and some influenza vaccines. Development Attenua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and recognize further and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylaxis, prophylactic (to prevent or alleviate the effects of a future infection by a natural or "wild" pathogen), or therapeutic vaccines, therapeutic (to fight a disease that has already occurred, such as cancer vaccine, cancer). Some vaccines offer full sterilizing immunity, in which infection is prevented. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transmission (medicine)
In medicine, public health, and biology, transmission is the passing of a pathogen causing Infectious disease, communicable disease from an infected host (biology), host individual or group to a particular individual or group, regardless of whether the other individual was previously infected. The term strictly refers to the transmission of microorganisms directly from one individual to another by one or more of the following means: * airborne transmission – very small dry and wet particles that stay in the air for long periods of time allowing airborne contamination even after the departure of the host. Particle size 5 μm. * direct physical contact – touching an infected individual, including sexual contact * indirect physical contact – usually by touching a contaminated surface, including soil (fomite) * fecal–oral route, fecal–oral transmission – usually from unwashed hands, contaminated food or water sources due to lack of sanitation and hygiene, an important tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extinction
Extinction is the termination of an organism by the death of its Endling, last member. A taxon may become Functional extinction, functionally extinct before the death of its last member if it loses the capacity to Reproduction, reproduce and recover. As a species' potential Range (biology), range may be very large, determining this moment is difficult, and is usually done retrospectively. This difficulty leads to phenomena such as Lazarus taxon, Lazarus taxa, where a species presumed extinct abruptly "reappears" (typically in the Fossil, fossil record) after a period of apparent absence. Over five billion species are estimated to have died out. It is estimated that there are currently around 8.7 million species of eukaryotes globally, possibly many times more if microorganisms are included. Notable extinct animal species include Dinosaur, non-avian dinosaurs, Machairodontinae, saber-toothed cats, and mammoths. Through evolution, species arise through the process of specia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wild Type
The wild type (WT) is the phenotype of the typical form of a species as it occurs in nature. Originally, the wild type was conceptualized as a product of the standard "normal" allele at a locus, in contrast to that produced by a non-standard, " mutant" allele. "Mutant" alleles can vary to a great extent, and even become the wild type if a genetic shift occurs within the population. Continued advancements in genetic mapping technologies have created a better understanding of how mutations occur and interact with other genes to alter phenotype. It is now regarded that most or all gene loci exist in a variety of allelic forms, which vary in frequency throughout the geographic range of a species, and that a uniform wild type does not exist. In general, however, the most prevalent allele – i.e., the one with the highest gene frequency – is the one deemed wild type. The concept of wild type is useful in some experimental organisms such as fruit flies ''Drosophila melanogaster'', ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pakistan
Pakistan, officially the Islamic Republic of Pakistan, is a country in South Asia. It is the List of countries and dependencies by population, fifth-most populous country, with a population of over 241.5 million, having the Islam by country#Countries, second-largest Muslim population as of 2023. Islamabad is the nation's capital, while Karachi is List of cities in Pakistan by population, its largest city and financial centre. Pakistan is the List of countries and dependencies by area, 33rd-largest country by area. Bounded by the Arabian Sea on the south, the Gulf of Oman on the southwest, and the Sir Creek on the southeast, it shares land borders with India to the east; Afghanistan to the west; Iran to the southwest; and China to the northeast. It shares a maritime border with Oman in the Gulf of Oman, and is separated from Tajikistan in the northwest by Afghanistan's narrow Wakhan Corridor. Pakistan is the site of History of Pakistan, several ancient cultures, including the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Afghanistan
Afghanistan, officially the Islamic Emirate of Afghanistan, is a landlocked country located at the crossroads of Central Asia and South Asia. It is bordered by Pakistan to the Durand Line, east and south, Iran to the Afghanistan–Iran border, west, Turkmenistan to the Afghanistan–Turkmenistan border, northwest, Uzbekistan to the Afghanistan–Uzbekistan border, north, Tajikistan to the Afghanistan–Tajikistan border, northeast, and China to the Afghanistan–China border, northeast and east. Occupying of land, the country is predominantly mountainous with plains Afghan Turkestan, in the north and Sistan Basin, the southwest, which are separated by the Hindu Kush mountain range. Kabul is the country's capital and largest city. Demographics of Afghanistan, Afghanistan's population is estimated to be between 36 and 50 million. Ancient history of Afghanistan, Human habitation in Afghanistan dates to the Middle Paleolithic era. Popularly referred to as the graveyard of empire ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endemic (epidemiology)
In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly present, or maintained at a baseline level, without extra infections being brought into the group as a result of travel or similar means. The term describes the distribution of an infectious disease among a group of people or within a populated area. An endemic disease always has a steady, predictable number of people getting sick, but that number can be high ('' hyperendemic'') or low (''hypoendemic''), and the disease can be severe or mild. Also, a disease that is usually endemic can become epidemic. For example, chickenpox is endemic in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus '' Anopheles''). Consequently, there is no constant baseline level of malaria inf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nigeria
Nigeria, officially the Federal Republic of Nigeria, is a country in West Africa. It is situated between the Sahel to the north and the Gulf of Guinea in the Atlantic Ocean to the south. It covers an area of . With Demographics of Nigeria, a population of more than 230 million, it is the List of African countries by population, most populous country in Africa, and the List of countries and dependencies by population, world's sixth-most populous country. Nigeria borders Niger in Niger–Nigeria border, the north, Chad in Chad–Nigeria border, the northeast, Cameroon in Cameroon–Nigeria border, the east, and Benin in Benin–Nigeria border, the west. Nigeria is a Federation, federal republic comprising 36 States of Nigeria, states and the Federal Capital Territory, Nigeria, Federal Capital Territory, where its capital, Abuja, is located. The List of Nigerian cities by population, largest city in Nigeria by population is Lagos, one of the largest List of largest cities, metr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunodeficient
Immunodeficiency, also known as immunocompromise, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired ("secondary") due to extrinsic factors that affect the patient's immune system. Examples of these extrinsic factors include HIV infection and environmental factors, such as nutrition. Immunocompromisation may also be due to genetic diseases/flaws such as SCID. In clinical settings, immunosuppression by some drugs, such as steroids, can either be an adverse effect or the intended purpose of the treatment. Examples of such use is in organ transplant surgery as an anti- rejection measure and in patients with an overactive immune system, as in autoimmune diseases. Some people are born with intrinsic defects in their immune system, or primary immunodeficiency. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised individual may particula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asymptomatic
Asymptomatic (or clinically silent) is an adjective categorising the medical conditions (i.e., injuries or diseases) that patients carry but without experiencing their symptoms, despite an explicit diagnosis (e.g., a positive medical test). Pre-symptomatic is the adjective categorising the time periods during which the medical conditions are asymptomatic. Subclinical and paucisymptomatic are other adjectives categorising either the asymptomatic infections (i.e., subclinical infections), or the psychosomatic illnesses and mental disorders expressing a subset of symptoms but not the entire set an explicit medical diagnosis requires. Examples An example of an asymptomatic disease is cytomegalovirus (CMV) which is a member of the herpes virus family. "It is estimated that 1% of all newborns are infected with CMV, but the majority of infections are asymptomatic." (Knox, 1983; Kumar et al. 1984) In some diseases, the proportion of asymptomatic cases can be important. For exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
