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Physics Of Consciousness
Neurophysics (or neurobiophysics) is the branch of biophysics dealing with the development and use of physical methods to gain information about the nervous system. Neurophysics is an interdisciplinary science using physics and combining it with other neurosciences to better understand neural processes. The methods used include the techniques of experimental biophysics and other physical measurements such as EEG mostly to study electrical, mechanical or fluidic properties, as well as theoretical and computational approaches. The term "neurophysics" is a portmanteau of "neuron" and "physics". Among other examples, the theorisation of ectopic action potentials in neurons using a Kramers-Moyal expansion and the description of physical phenomena measured during an EEG using a dipole approximation use neurophysics to better understand neural activity. Another quite distinct theoretical approach considers neurons as having Ising model energies of interaction and explores the physical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysics
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology. The term ''biophysics'' was originally introduced by Karl Pearson in 1892. Roland Glaser. Biophysics: An Introduction'. Springer; 23 April 2012. . The term ''biophysics'' is also regularly used in academia to indicate the study of the physical quantities (e.g. electric current, temperature, stress, entropy) in biological systems. Other biological sciences also perform research on the biophysical properties of living organisms including molecular biology, cell biology, chemical biology, and biochemistry. O ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research
Research is "creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness to controlling sources of bias and error. These activities are characterized by accounting and controlling for biases. A research project may be an expansion on past work in the field. To test the validity of instruments, procedures, or experiments, research may replicate elements of prior projects or the project as a whole. The primary purposes of basic research (as opposed to applied research) are documentation, discovery, interpretation, and the research and development (R&D) of methods and systems for the advancement of human knowledge. Approaches to research depend on epistemologies, which vary considerably both within and between humanities and sciences. There are several forms of research: scientific, humanities, artistic, econ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Watt W
The watt (symbol: W) is the unit of power or radiant flux in the International System of Units (SI), equal to 1 joule per second or 1 kg⋅m2⋅s−3. It is used to quantify the rate of energy transfer. The watt is named after James Watt (1736–1819), an 18th-century Scottish inventor, mechanical engineer, and chemist who improved the Newcomen engine with his own steam engine in 1776. Watt's invention was fundamental for the Industrial Revolution. Overview When an object's velocity is held constant at one metre per second against a constant opposing force of one newton, the rate at which work is done is one watt. : \mathrm In terms of electromagnetism, one watt is the rate at which electrical work is performed when a current of one ampere (A) flows across an electrical potential difference of one volt (V), meaning the watt is equivalent to the volt-ampere (the latter unit, however, is used for a different quantity from the real power of an electrical circuit). : \mathr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Brain Prize
The Brain Prize, formerly known as The Grete Lundbeck European Brain Research Prize, is an international scientific award honouring "one or more scientists who have distinguished themselves by an outstanding contribution to neuroscience and who are still active in research". Founded in 2011 by thLundbeck Foundation the prize is associated with a DKK 10 million award to the nominees, the world’s largest brain research prize. Nominees can be of any nationality. Prize winners are expected to interact with Danish brain researchers e.g. through lectures, master classes, seminars, exchange programmes for researchers or other activities agreed with and financially supported by the Lundbeck Foundation. History The Brain Prize was established by the Lundbeck Foundation in 2010 as a European prize and was awarded for the first time in 2011. Today the Prize is global. Selection committee As of 2019, the selection committee for the prize consisted of: *Richard G. Morris (chair) *Story Landi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Winfried Denk
Winfried Denk (born November 12, 1957 in Munich) is a German physicist. He built the first two-photon microscope while he was a graduate student (and briefly a postdoc) in Watt W. Webb's lab at Cornell University, in 1989. Early life and education Denk was born in Munich, Germany. As a child he spent most of his playtime learning to use the tools and building materials in his father's workshop. In school it became apparent that Denk’s ‘talents were unevenly spread across subjects, math and physics being favored’. Fixing and constructing electronic devices was his main hobby throughout high school. After high school, Denk completed the mandatory 15-month stint in the German army and spent the next 3 years at the Ludwig Maximilian University of Munich. In 1981 he moved to Zurich to study at the ETH. During this time, he also worked in the lab of Dieter Pohl, at the IBM laboratory. There he built one of the first super-resolution microscopes and developed a passion for sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Two-photon Excitation Microscopy
Two-photon excitation microscopy (TPEF or 2PEF) is a fluorescence imaging technique that allows imaging of living tissue up to about one millimeter in thickness, with 0.64 μm lateral and 3.35 μm axial spatial resolution. Unlike traditional fluorescence microscopy, in which the excitation wavelength is shorter than the emission wavelength, two-photon excitation requires simultaneous excitation by two photons with longer wavelength than the emitted light. Two-photon excitation microscopy typically uses near-infrared (NIR) excitation light which can also excite fluorescent dyes. However, for each excitation, two photons of NIR light are absorbed. Using infrared light minimizes scattering in the tissue. Due to the multiphoton absorption, the background signal is strongly suppressed. Both effects lead to an increased penetration depth for this technique. Two-photon excitation can be a superior alternative to confocal microscopy due to its deeper tissue penetration, efficient light d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, although "open ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seiji Ogawa
Seiji Ogawa (小川 誠二 ''Ogawa Seiji'', born January 19, 1934) is a Japanese biophysicist and neuroscientist known for discovering the technique that underlies Functional Magnetic Resonance Imaging (fMRI). He is regarded as the father of modern functional brain imaging. He determined that the changes in blood oxygen levels cause its magnetic resonance imaging properties to change, allowing a map of blood, and hence, functional, activity in the brain to be created. This map reflected which neurons of the brain responded with electrochemical signals to mental processes. He was the first scientist who demonstrated that the functional brain imaging is dependent on the oxygenation status of the blood, the BOLD effect. The technique was therefore called blood oxygenation level-dependent or BOLD contrast. Functional MRI (fMRI) has been used to map the visual, auditory, and sensory regions and moving toward higher brain functions such as cognitive functions in the brain. In 2020, O ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Functional Magnetic Resonance Imaging
Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa in 1990. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow ( hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not involve the use of injections, surgery, the ingestion of substances, or exposure to ionizing radiation. This measure is frequently corrupted by noise from various sources; hence, statistical procedures are used to extract the underlying sig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebral Cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the cranium. Apart from minimising brain and cranial volume, cortical folding is crucial for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Craniotomy
A craniotomy is a surgical operation in which a bone flap is temporarily removed from the skull to access the brain. Craniotomies are often critical operations, performed on patients who are suffering from brain lesions, such as tumors, blood clots, removal of foreign bodies such as bullets, or traumatic brain injury (TBI), and can also allow doctors to surgically implant devices, such as deep brain stimulators for the treatment of Parkinson's disease, epilepsy, and cerebellar tremor. The procedure is also used in epilepsy surgery to remove the parts of the brain that are causing epilepsy. Craniotomy is distinguished from craniectomy (in which the skull flap is not immediately replaced, allowing the brain to swell, thus reducing intracranial pressure) and from trepanation, the creation of a burr hole through the cranium in to the dura mater. Procedure Human craniotomy is usually performed under general anesthesia but can be also done with the patient awake using a local anaesth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrocorticography
Electrocorticography (ECoG), or intracranial electroencephalography (iEEG), is a type of electrophysiological monitoring that uses electrodes placed directly on the exposed surface of the brain to record electrical activity from the cerebral cortex. In contrast, conventional electroencephalography (EEG) electrodes monitor this activity from outside the skull. ECoG may be performed either in the operating room during surgery (intraoperative ECoG) or outside of surgery (extraoperative ECoG). Because a craniotomy (a surgical incision into the skull) is required to implant the electrode grid, ECoG is an invasive procedure. History ECoG was pioneered in the early 1950s by Wilder Penfield and Herbert Jasper, neurosurgeons at the Montreal Neurological Institute. The two developed ECoG as part of their groundbreakinMontreal procedure a surgical protocol used to treat patients with severe epilepsy. The cortical potentials recorded by ECoG were used to identify epileptogenic zone ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
