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Phenotypic Screening
Phenotypic screening is a type of screening used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell or an organism in a desired manner. Phenotypic screening must be followed up with identification (sometimes referred to as target deconvolution) and validation, often through the use of chemoproteomics, to identify the mechanisms through which a phenotypic hit works. Historical context Phenotypic screening historically has been the basis for the discovery of new drugs. Compounds are screened in cellular or animal disease models to identify compounds that cause a desirable change in phenotype. Only after the compounds have been discovered are efforts made to determine the biological targets of the compounds - a process known as target deconvolution. This overall strategy is referred to as " classical pharmacology", "forward pharmacology" or "phenotypic drug discovery" (PDD). More rece ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Screening (medicine)
In medicine, screening is a strategy used to look for as-yet-unrecognised conditions or risk markers. This testing can be applied to individuals or to a whole population without symptoms or signs of the disease being screened. Screening Public health intervention, interventions are designed to identify conditions which could at some future point turn into disease, thus enabling earlier intervention and management in the hope to reduce mortality and suffering from a disease. Although screening may lead to an earlier diagnosis, not all screening tests have been shown to benefit the person being screened; overdiagnosis, misdiagnosis, and creating a false sense of security are some potential Adverse effect (medicine), adverse effects of screening. Additionally, some screening tests can be inappropriately overused. For these reasons, a test used in a screening program, especially for a disease with low Incidence (epidemiology), incidence, must have good Sensitivity (tests), sensitivity ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Melanogaster
''Drosophila melanogaster'' is a species of fly (an insect of the Order (biology), order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly", "pomace fly", or "banana fly". In the wild, ''D. melanogaster'' are attracted to rotting fruit and fermenting beverages, and are often found in orchards, kitchens and pubs. Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, ''D. melanogaster'' continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and Life history theory, life history evolution. ''D. melanogaster'' was the first animal to be Fruit flies in space, launched into space in 1947. As of 2017, six Nobel Prizes have been awarded to drosophilists for their work using the insect. ''Drosophila melanogaster'' is typically used in research owing to its rapid life cycle, relatively simple genetics with on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Persomics
Persomics is a private life science company specializing in genetic research, with locations in Boston, MA, Cupertino, CA, and Gothenburg, Sweden. The company’s aim is to simplify and expedite the process of discovering the basis of disease, and it has established a particular phenotypic screening kit that it uses for this purpose. These kits facilitate the interrogation of thousands of genes in parallel, and therefore pertain to human genome, pharmaceutical and disease model research. Technology By 2013 the drug discovery market had begun shifting from the single to the multi-target paradigm, of which Persomics’ technology is a part. Prior to that time, popular drug discovery efforts focused on identifying single drugs that fit into specific cellular targets; this came to be known as target-based screening (i.e. reverse pharmacology). The multi-target approach entails the understanding that, although one drug compound might fit into a single target, diseases are associa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ThermoFisher
Thermo Fisher Scientific Inc. is an American life science and clinical research company. It is a global supplier of analytical instruments, clinical development solutions, specialty diagnostics, laboratory, pharmaceutical and biotechnology services. Based in Waltham, Massachusetts, Thermo Fisher was formed through the merger of Thermo Electron and Fisher Scientific in 2006. Thermo Fisher Scientific has acquired other reagent, consumable, instrumentation, and service providers, including Life Technologies Corporation (2013), Alfa Aesar (2015), Affymetrix (2016), FEI Company (2016), BD Advanced Bioprocessing (2018), and PPD (2021). , the company had a market capitalization of $202 billion. It ranked 97th on the ''Fortune'' 500 list based on its 2022 annual revenue of US$44.92 billion. History Predecessors and merger Thermo Electron was co-founded in 1956 by George N. Hatsopoulos and Peter M Nomikos. Hatsopoulos received a PhD from MIT in mechanical engineering and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evotec
Evotec SE is a publicly listed drug discovery and development company headquartered in Hamburg, Germany. The company operates globally, largely through external alliances with pharmaceutical and biotechnology companies, academic institutions, patient advocacy groups, and venture capitalists. As of 31 December 2021 Evotec had a market capitalization of €7.5 billion and a pipeline of more than 130 partnered programs in discovery, pre-clinical development and clinical development. The company's 4,200+ employees work across a number of therapeutic areas including CNS/neurology (e.g. Alzheimer's disease, Huntington's disease), metabolic diseases (e.g. Diabetes), Cancer, and inflammatory and infectious diseases. It has long-term discovery alliances with Bristol Myers Squibb, Bayer, Sanofi, Boehringer Ingelheim, the CHDI Foundation, Lilly, Takeda, Sernova, and more. On 28 October 2009 the company was listed on the TecDAX index, which tracks the performance of the 30 larg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sosei (company)
Sosei (, 844 – 910) was a Japanese waka poet and Buddhist priest. He is listed as one of the Thirty-six Poetry Immortals, and one of his poems was included in the famous anthology ''Hyakunin Isshu''. His father Henjō was also a waka poet and monk. Sosei entered religious life sometime after his father, who took the tonsure after the death of Emperor Ninmyō in 850. His father is said to have pushed him into joining religion, and we can find a total of 36 poems by him in the Kokin Wakashū The , commonly abbreviated as , is an early anthology of the '' waka'' form of Japanese poetry, dating from the Heian period. An imperial anthology, it was conceived by Emperor Uda () and published by order of his son Emperor Daigo () in abou .... Waka Poems Sokoi-naki fuchi-yawa-sawagu yamagawa-no asaki-seni-koso adanami-wa-tate (Kokin waka shu) Translation: The deep pools do not have waves, but the shallow rapids of mountain rivers often have waves. Interpretation of love: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melior Discovery
Melior Discovery, Inc. is a private biopharmaceutical company based in Exton, Pennsylvania, USA. Products and services The company specializes in drug repositioning and has established a proprietary phenotypic screening platform that it uses for this purpose. Melior also offers certain contract research organization (CRO) services comprising animal models representing different disease conditions. The Company has issued press releases disclosing partnerships with Pfizer, Merck & Co., Johnson & Johnson, and AstraZeneca, all citing the use of the company's drug repositioning technology. Melior Discovery has also used its technology to discover its own drug candidates. History Melior Discovery was co-founded in 2005 by Dr. Andrew Reaume (President and CEO) and Dr. Michael Saporito (Vice President of Research). Its investors include Cammeby's Capital Group, VenturEast, Osage Ventures, Mid-Atlantic Angel Group, and BioAdvance. In March 2009, the Food and Drug Administration (FDA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Repositioning
Drug repositioning (also called drug repurposing) involves the investigation of existing drugs for new therapeutic purposes. Repurposing achievements Repurposing generics can have groundbreaking effects for patients: 35% of 'transformative' drugs approved by the US FDA are repurposed products. Repurposing is especially relevant for rare or neglected diseases. A number of successes have been achieved, the foremost including sildenafil (Viagra) for erectile dysfunction and pulmonary hypertension and thalidomide for leprosy and multiple myeloma. Clinical trials have been performed on posaconazole and ravuconazole for Chagas disease. Other antifungal agents clotrimazole and ketoconazole have been investigated for anti- trypanosome therapy. Successful repositioning of antimicrobials has led to the discovery of broad-spectrum therapeutics, which are effective against multiple infection types. Strategy Drug repositioning is a "universal strategy" for neglected diseases due to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mus Musculus
The house mouse (''Mus musculus'') is a small mammal of the rodent family Muridae, characteristically having a pointed snout, large rounded ears, and a long and almost hairless tail. It is one of the most abundant species of the genus ''Mus (genus), Mus''. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common than the synanthropic populations near human activity. The house mouse has been domestication, domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was Whole genome sequencing, sequenced in 2002. Characteristics House mice have an adult body length (nose to base of tail) of and a tail length of . The weight is typically . In the wild they vary in color from grey and light brown to black (individual hairs are actually Agouti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Danio Rerio
The zebrafish (''Danio rerio'') is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a " tropical fish" although it is both tropical and subtropical). The zebrafish is an important and widely used vertebrate model organism in scientific research, particularly developmental biology, but also gene function, oncology, teratology, and drug development, in particular pre-clinical development. It is also notable for its regenerative abilities, and has been modified by researchers to produce many transgenic strains. Taxonomy The zebrafish is a derived member of the genus '' Brachydanio'', of the family Cyprinidae. It has a sister-group relationship with '' Danio aesculapii''. Zebrafish are also closely related to the genus '' Devario'', as demonstrated by a phylogenetic tree of close species. Distr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
