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Peter Medawar
Sir Peter Brian Medawar (; 28 February 1915 – 2 October 1987) was a British biologist and writer, whose works on graft rejection and the discovery of acquired immune tolerance have been fundamental to the medical practice of tissue and organ transplants. For his scientific works, he is regarded as the "father of transplantation". He is remembered for his wit both in person and in popular writings. Richard Dawkins referred to him as "the wittiest of all scientific writers"; Stephen Jay Gould as "the cleverest man I have ever known". Medawar was the youngest child of a Lebanese people, Lebanese father and a British mother, and was both a Brazilian and British citizen by birth. He studied at Marlborough College and Magdalen College, Oxford, and was professor of zoology at the University of Birmingham and University College London. Until he was partially disabled by a cerebral infarction, he was Director of the National Institute for Medical Research at Mill Hill. With his doctor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petrópolis
Petrópolis (), also known as the Imperial City, is a municipality in the Southeast Region of Brazil. It is located in the state of Rio de Janeiro, northeast of the city of Rio de Janeiro. According to the 2022 Brazilian census, Petrópolis municipality had a population of 278,881 inhabitants. Besides being the largest and most populous city in the , the city also has the largest GDP and HDI in the region. The town's name ("City of Peter") honors Pedro II, the last Emperor of Brazil, who is entombed there at the Cathedral of Saint Peter of Alcantara. The city was the summer residence of the Brazilian Emperors and aristocrats in the 19th century, and was the official capital of the state of Rio de Janeiro during the First Brazilian Republic, between 1894 and 1902. There are projects to annex Petrópolis again to the Metropolitan Region of Rio de Janeiro, because it is linked to the capital by political and economic ties and contains one of the state's highest HDIs. Histor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Copley Medal
The Copley Medal is the most prestigious award of the Royal Society of the United Kingdom, conferred "for sustained, outstanding achievements in any field of science". The award alternates between the physical sciences or mathematics and the biological sciences. It is arguably the highest United Kingdom, British and Commonwealth of Nations, Commonwealth award for scientific achievement, and has often been included among the most distinguished international scientific awards. Given annually, the medal is the oldest Royal Society medal awarded and the oldest surviving scientific award in the world, having first been given in 1731 to Stephen Gray (scientist), Stephen Gray, for "his new Electrical Experiments: – as an encouragement to him for the readiness he has always shown in obliging the Society with his discoveries and improvements in this part of Natural Knowledge". The medal is made of silver-gilt and awarded with a £25,000 prize. It is awarded to "senior scientists" irres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebral Infarction
Cerebral infarction, also known as an ischemic stroke, is the pathologic process that results in an area of necrotic tissue in the brain (cerebral infarct). In mid to high income countries, a stroke is the main reason for disability among people and the 2nd cause of death. It is caused by disrupted blood supply (ischemia) and restricted oxygen supply ( hypoxia). This is most commonly due to a thrombotic occlusion, or an embolic occlusion of major vessels which leads to a cerebral infarct . In response to ischemia, the brain degenerates by the process of liquefactive necrosis. Classification There are various classification systems for cerebral infarcts, some of which are described below. * The Oxford Community Stroke Project classification (OCSP, also known as the Bamford or Oxford classification) relies primarily on the initial symptoms. Based on the extent of the symptoms, the stroke episode is classified as total anterior circulation infarct (TACI), partial anterior circ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marlborough College
Marlborough College is a Public school (United Kingdom), public school (English private boarding school) for pupils aged 13 to 18 in Marlborough, Wiltshire, England. It was founded as Marlborough School in 1843 by the Dean of Manchester, George Hull Bowers, for the education of the sons of Church of England clergy. It is one of the oldest boarding schools in the UK, and now adopts a co-educational model. In 2023 there were around 1000 pupils, approximately 45% of whom were female. In 2024, the school was included in The Schools Index as one of the 150 best private schools in the world and among the top 30 senior schools in the UK. Fees for boarding pupils in 2024/2025 are £50,985 per year. History Marlborough was, in 1968, the first major British independent boys' school to allow girls into the sixth form, setting a trend that many other schools followed. The school became fully co-educational in 1989, and made a major contribution to the School Mathematics Project (from 196 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lebanese People
The Lebanese people ( / Romanization of Arabic, ALA-LC: ', ) are the people inhabiting or originating from Lebanon. The term may also include those who had inhabited Mount Lebanon and the Anti-Lebanon Mountains prior to the creation of the modern Lebanese state. The major religious groups among the Lebanese people within Lebanon are Lebanese people (Shia Muslims), Shia Muslims (27%), Lebanese people (Sunni Muslims), Sunni Muslims (27%), Lebanese people (Maronite Christians), Maronite Christians (21%), Lebanese people (Greek Orthodox Christians), Greek Orthodox Christians (8%), Lebanese people (Melkite Christians), Melkite Christians (5%), Lebanese people (Druze followers), Druze (5%), Lebanese people (Protestant Christians), Protestant Christians (1%). The largest contingent of Lebanese, however, comprise a Lebanese diaspora, diaspora in North America, South America, Europe, Australia and Africa, which is predominantly Maronite Christian. As the relative proportion of the vario ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stephen Jay Gould
Stephen Jay Gould ( ; September 10, 1941 – May 20, 2002) was an American Paleontology, paleontologist, Evolutionary biology, evolutionary biologist, and History of science, historian of science. He was one of the most influential and widely read authors of popular science of his generation. Gould spent most of his career teaching at Harvard University and working at the American Museum of Natural History in New York. In 1996, Gould was hired as the Vincent Astor Visiting Research Professor of Biology at New York University, after which he divided his time teaching between there and Harvard. Gould's most significant contribution to evolutionary biology was the theory of punctuated equilibrium developed with Niles Eldredge in 1972.Eldredge, Niles, and S. J. Gould (1972)"Punctuated equilibria: an alternative to phyletic gradualism."In T.J.M. Schopf, ed., ''Models in Paleobiology''. San Francisco: Freeman, Cooper and Company, pp. 82–115. The theory proposes that most evolution is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Dawkins
Richard Dawkins (born 26 March 1941) is a British evolutionary biology, evolutionary biologist, zoologist, science communicator and author. He is an Oxford fellow, emeritus fellow of New College, Oxford, and was Simonyi Professor for the Public Understanding of Science, Professor for Public Understanding of Science at the University of Oxford from 1995 to 2008, and is on the advisory board of the University of Austin. His book ''The Selfish Gene'' (1976) popularised the gene-centred view of evolution and coined the word ''meme''. Dawkins has won several academic and writing awards. A vocal Atheism, atheist, Dawkins is known for his criticism of creationism and intelligent design. He wrote ''The Blind Watchmaker'' (1986), in which he argues against the watchmaker analogy, an argument for the existence of a creator deity based upon the Evolution of biological complexity, complexity of living organisms. Instead, he describes evolutionary processes as analogous to a ''blind'' watc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organ Transplants
Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source. Organs that have been successfully transplanted include the heart, kidneys, liver, lungs, pancreas, intestine, thymus and uterus. Tissues include bones, tendons (both referred to as musculoskeletal grafts), corneae, skin, heart valves, nerves and veins. Worldwide, the kidneys are the most commonly transplanted organs, followed by the liver and then the heart. J. Hartwell Harrison performed the first organ removal for transplant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acquired Immune Tolerance
Immune tolerance, also known as immunological tolerance or immunotolerance, refers to the immune system's state of unresponsiveness to substances or tissues that would otherwise trigger an immune response. It arises from prior exposure to a specific antigen and contrasts the immune system's conventional role in eliminating foreign antigens. Depending on the site of induction, tolerance is categorized as either central tolerance, occurring in the thymus and bone marrow, or peripheral tolerance, taking place in other tissues and lymph nodes. Although the mechanisms establishing central and peripheral tolerance differ, their outcomes are analogous, ensuring immune system modulation. Immune tolerance is important for normal physiology and homeostasis. Central tolerance is crucial for enabling the immune system to differentiate between self and non-self antigens, thereby preventing autoimmunity. Peripheral tolerance plays a significant role in preventing excessive immune reactions to en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Graft Rejection
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types Transplant rejection can be classified into three types: hyperacute, acute, and chronic. These types are differentiated by how quickly the recipient's immune system is activated and the specific aspect or aspects of immunity involved. Hyperacute rejection Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. It is caused by the presence of pre-existing antibodies in the recipient that recognize antigens in the donor organ. These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, will lead to the rapid activation of the complement system. Irrevers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biographical Memoirs Of Fellows Of The Royal Society
The ''Biographical Memoirs of Fellows of the Royal Society'' is an academic journal on the history of science published annually by the Royal Society. It publishes obituaries of Fellows of the Royal Society. It was established in 1932 as ''Obituary Notices of Fellows of the Royal Society'' and obtained its current title in 1955, with volume numbering restarting at 1. Prior to 1932, obituaries were published in the '' Proceedings of the Royal Society''. The memoirs are a significant historical record and most include a full bibliography of works by the subjects. The memoirs are often written by a scientist of the next generation, often one of the subject's own former students, or a close colleague. In many cases the author is also a Fellow. Notable biographies published in this journal include Albert Einstein, Alan Turing, Bertrand Russell Bertrand Arthur William Russell, 3rd Earl Russell, (18 May 1872 – 2 February 1970) was a British philosopher, logician, mathematic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alex Garland
Alexander Medawar Garland (born 26 May 1970) is an English author, screenwriter, and director. He rose to prominence with his novel '' The Beach'' (1996). He received praise for writing the Danny Boyle films '' 28 Days Later'' (2002) and '' Sunshine'' (2007), as well as '' Never Let Me Go'' (2010) and '' Dredd'' (2012). In video games, he co-wrote '' Enslaved: Odyssey to the West'' (2010) and was a story supervisor on '' DmC: Devil May Cry'' (2013). Garland made his directorial debut when he wrote and directed the sci-fi thriller '' Ex Machina'' (2014). He earned an Academy Award nomination for Best Original Screenplay, and won him three British Independent Film Awards, including Best Screenplay, Best Director, and Best British Independent Film for the film. His second movie, ''Annihilation'' (2018), an adaptation of the 2014 novel of the same name, was a critical success. He wrote, directed and executive produced the FX miniseries '' Devs'' (2020) followed by the horror t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
