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Peter Kohl (scientist)
Peter Kohl Fellow of the American Heart Association, FAHA Heart Rhythm Society, FHRS The Physiological Society, FTPS is a scientist specializing in integrative cardiac research. He studies heterocellular electrophysiological interactions in cardiac tissue, myocardial structure-function relationships using 'wet' and 'dry' lab models, and mechano-electrical autoregulation of the heart. Education Kohl studied medicine and biophysics in Moscow before completing his doctorate and his residency in physiology at the Humboldt University in Berlin. Supported by a scholarship from thBoehringer-Ingelheim Foundation he went as a post-doctoral researcher to the chair of Denis Noble, Prof. Denis Noble, Department of Physiology at the University of Oxford, where - using a combination of experimental and theoretical models - he explored cardiac mechanobiology and heterocellular interactions. Career Supported by personal fellowships from the UK Royal Society and the British Heart Foundation, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berlin
Berlin is Capital of Germany, the capital and largest city of Germany, both by area and List of cities in Germany by population, by population. Its more than 3.85 million inhabitants make it the European Union's List of cities in the European Union by population within city limits, most populous city, as measured by population within city limits having gained this status after the United Kingdom's, and thus London's, Brexit, departure from the European Union. Simultaneously, the city is one of the states of Germany, and is the List of German states by area, third smallest state in the country in terms of area. Berlin is surrounded by the state of Brandenburg, and Brandenburg's capital Potsdam is nearby. The urban area of Berlin has a population of over 4.5 million and is therefore the most populous urban area in Germany. The Berlin/Brandenburg Metropolitan Region, Berlin-Brandenburg capital region has around 6.2 million inhabitants and is Germany's second-largest metropolitan reg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humboldt University
The Humboldt University of Berlin (german: link=no, Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a public research university in the central borough of Mitte in Berlin, Germany. The university was established by Frederick William III on the initiative of Wilhelm von Humboldt, Johann Gottlieb Fichte and Friedrich Daniel Ernst Schleiermacher as the University of Berlin () in 1809, and opened in 1810, making it the oldest of Berlin's four universities. From 1828 until its closure in 1945, it was named Friedrich Wilhelm University (german: link=no, Friedrich-Wilhelms-Universität). During the Cold War, the university found itself in East Berlin and was ''de facto'' split in two when the Free University of Berlin opened in West Berlin. The university received its current name in honour of Alexander and Wilhelm von Humboldt in 1949. The university is divided into nine faculties including its medical school shared with the Freie Universität Berlin. The university h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biobank
A biobank is a type of biorepository that stores biological samples (usually human) for use in research. Biobanks have become an important resource in medical research, supporting many types of contemporary research like genomics and personalized medicine. Biobanks can give researchers access to data representing a large number of people. Samples in biobanks and the data derived from those samples can often be used by multiple researchers for cross purpose research studies. For example, many diseases are associated with single-nucleotide polymorphisms. Genome-wide association studies using data from tens or hundreds of thousands of individuals can identify these genetic associations as potential disease biomarkers. Many researchers struggled to acquire sufficient samples prior to the advent of biobanks. Biobanks have provoked questions on privacy, research ethics, and medical ethics. Viewpoints on what constitutes appropriate biobank ethics diverge. However, a consensus has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Freiburg University
The University of Freiburg (colloquially german: Uni Freiburg), officially the Albert Ludwig University of Freiburg (german: Albert-Ludwigs-Universität Freiburg), is a public research university located in Freiburg im Breisgau, Baden-Württemberg, Germany. The university was founded in 1457 by the Habsburg dynasty as the second university in Austrian-Habsburg territory after the University of Vienna. Today, Freiburg is the fifth-oldest university in Germany, with a long tradition of teaching the humanities, social sciences and natural sciences and technology and enjoys a high academic reputation both nationally and internationally. The university is made up of 11 faculties and attracts students from across Germany as well as from over 120 other countries. Foreign students constitute about 18.2% of total student numbers. The University of Freiburg has been associated with figures such as Hannah Arendt, Rudolf Carnap, David Daube, Johann Eck, Hans-Georg Gadamer, Friedrich Hay ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optogenetic
Optogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes specifically in the target cells. On the level of individual cells, light-activated enzymes and transcription factors allow precise control of biochemical signaling pathways. In systems neuroscience, the ability to control the activity of a genetically defined set of neurons has been used to understand their contribution to decision making, learning, fear memory, mating, addiction, feeding, and locomotion. In a first medical application of optogenetic technology, vision was partially restored in a blind patient. Optogenetic techniques have also been introduced to map the functional connectivity of the brain''.'' By altering the activity of genetically labelled neurons with light and using imaging and electrophysiology techniques to record the activity of other cells, researchers can identif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroblast
A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, produces the structural framework ( stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals. Structure Fibroblasts have a branched cytoplasm surrounding an elliptical, speckled nucleus having two or more nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum. Inactive fibroblasts (called fibrocytes) are smaller, spindle-shaped, and have a reduced amount of rough endoplasmic reticulum. Although disjointed and scattered when they have to cover a large space, fibroblasts, when crowded, often locally align in parallel clusters. Unlike the epithelial cells lining the body structures, fibroblasts do not form flat monolayers and are not restricted by a polarizing attachment to a basal lamina on one side, although they may contribute to basal lamina components in so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank–Starling Law
The Frank–Starling law of the heart (also known as Starling's law and the Frank–Starling mechanism) represents the relationship between stroke volume and end diastolic volume.Widmaier, E. P., Hershel, R., & Strang, K. T. (2016).''Vander's Human Physiology: The Mechanisms of Body Function''(14th ed.). New York, NY: McGraw-Hill Education. The law states that the stroke volume of the heart increases in response to an increase in the volume of blood in the ventricles, before contraction (the end diastolic volume), when all other factors remain constant. As a larger volume of blood flows into the ventricle, the blood stretches cardiac muscle, leading to an increase in the force of contraction. The Frank-Starling mechanism allows the cardiac output to be synchronized with the venous return, arterial blood supply and humoral length, without depending upon external regulation to make alterations. The physiological importance of the mechanism lies mainly in maintaining left and right v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarcoplasmic Reticulum
The sarcoplasmic reticulum (SR) is a membrane-bound structure found within muscle cells that is similar to the smooth endoplasmic reticulum in other cells. The main function of the SR is to store calcium ions (Ca2+). Calcium ion levels are kept relatively constant, with the concentration of calcium ions within a cell being 10,000 times smaller than the concentration of calcium ions outside the cell. This means that small increases in calcium ions within the cell are easily detected and can bring about important cellular changes (the calcium is said to be a second messenger). Calcium is used to make calcium carbonate (found in chalk) and calcium phosphate, two compounds that the body uses to make teeth and bones. This means that too much calcium within the cells can lead to hardening (calcification) of certain intracellular structures, including the mitochondria, leading to cell death. Therefore, it is vital that calcium ion levels are controlled tightly, and can be released in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patch Clamp
The patch clamp technique is a laboratory technique in electrophysiology used to study ionic currents in individual isolated living cells, tissue sections, or patches of cell membrane. The technique is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells, and can also be applied to the study of bacterial ion channels in specially prepared giant spheroplasts. Patch clamping can be performed using the voltage clamp technique. In this case, the voltage across the cell membrane is controlled by the experimenter and the resulting currents are recorded. Alternatively, the current clamp technique can be used. In this case, the current passing across the membrane is controlled by the experimenter and the resulting changes in voltage are recorded, generally in the form of action potentials. Erwin Neher and Bert Sakmann developed the patch clamp in the late 1970s and early 1980s. This discovery made it possib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pacemaker Cell
350px, Image showing the cardiac pacemaker or SA node, the primary pacemaker within the electrical conduction system of the heart. The muscle contraction, contraction of cardiac muscle (heart muscle) in all animals is initiated by electrical impulses known as action potentials that in the heart are known as cardiac action potentials. The rate at which these impulses fire controls the rate of cardiac contraction, that is, the heart rate. The cells that create these rhythmic impulses, setting the pace for blood pumping, are called pacemaker cells, and they directly control the heart rate. They make up the cardiac pacemaker, that is, the natural pacemaker of the heart. In most humans, the highest concentration of pacemaker cells is in the sinoatrial (SA) node the natural and primary pacemaker, and the resultant rhythm is a sinus rhythm. Sometimes a secondary pacemaker sets the pace, if the SA node is damaged or if the electrical conduction system of the heart has problems. Cardi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bainbridge Reflex
The Bainbridge reflex or Bainbridge effect, also called the atrial reflex, is an increase in heart rate due to an increase in central venous pressure. Increased blood volume is detected by stretch receptors (Cardiac Receptors) located in both sides of atria at the venoatrial junctions. History Francis Arthur Bainbridge described this as a reflex in 1918 when he was experimenting on dogs. Bainbridge found that infusing blood or saline into the animal increased heart rate. This phenomenon occurred even if arterial blood pressure did not increase. He further observed that heart rate increased when venous pressure rose high enough to distend the right atrium, but denervation of the vagi to the heart eliminated these effects. Subsequent work demonstrated that a stretch-induced increase in cardiac beating rate can also be observed in isolated hearts or even the fully separated SAN. Thus, the positive chronotropic (from Χρόνος, Greek for 'time', and τρέπειν, Greek for 'to bend ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Heart Foundation
The British Heart Foundation (BHF) is a cardiovascular research charity in the United Kingdom. It funds medical research related to heart and circulatory diseases and their risk factors, and runs influencing work aimed at shaping public policy and raising awareness. In 2021, a study conducted by YouGov ranked the British Heart Foundation as the top charity or organisation in the UK by % of adults who hold a positive opinion of the organisation. Foundation The British Heart Foundation was founded in 1961 by a group from the queens medical professionals who were concerned about the increasing death rate from cardiovascular disease. They wanted to fund extra research into the causes, diagnosis, treatment, and prevention of heart and circulatory diseases. It is a major funder and authority in cardiovascular research, education, and care, and relies predominantly on voluntary donations to meet its aims. In order to increase income and maximise the impact of its work, it also wo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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