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Paul W. Sternberg
Paul W. Sternberg is an American biologist. He does research for WormBase on ''C. elegans'', a model organism. Early life and education Paul Sternberg grew up in Long Island, New York. He attended Hampshire College for undergrad in Amherst, Massachusetts where he received his B.A. in 1978. After that he went to Massachusetts Institute of Technology, MIT where he received his PhD in Biology for work on nematode development with H. Robert Horvitz, Robert Horvitz. He went on to do postdoctoral research with Ira Herskowitz in yeast molecular development at the University of California San Francisco. He is currently the Thomas Hunt Morgan Professor of Biology at the California Institute of Technology. WormBase Sternberg is a Primary investigator for WormBase. WormBase is a data repository for nematode biology. ''C. elegans'' has been used in studies of development and neurobiology. WormBase has information from nine species and five are from the genus ''Caenorhabditis'', one of which i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WormBase
WormBase is an online biological database about the biology and genome of the nematode model organism ''Caenorhabditis elegans'' and contains information about other related nematodes. WormBase is used by the ''C. elegans'' research community both as an information resource and as a place to publish and distribute their results. The database is regularly updated with new versions being released every two months. WormBase is one of the organizations participating in the Generic Model Organism Database (GMOD) project. It is also part of the Alliance of Genome Resources. Contents WormBase comprises the following main data sets: *The annotated genomes of ''Caenorhabditis elegans'', ''Caenorhabditis briggsae'', ''Caenorhabditis remanei'', ''Caenorhabditis brenneri'', ''Caenorhabditis angaria'', ''Pristionchus pacificus'', ''Haemonchus contortus'', ''Meloidogyne hapla'', ''Meloidogyne incognita'', ''Brugia malayi'' and ''Onchocerca volvulus''; *Hand-curated annotations describing the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRISPR-Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna. More technically, Cas9 is a RNA-guided DNA endonuclease enzyme associated with the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) adaptive immune system in ''Streptococcus pyogenes''. ''S. pyogenes'' utilizes CRISPR to memorize and Cas9 to later interrogate and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. Cas9 performs this interrogation by unwinding foreign DNA and checking for sites complementary to the 20 nucleotide spacer region ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Biologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology School Of Science Alumni
Massachusetts ( ; ), officially the Commonwealth of Massachusetts, is a U.S. state, state in the New England region of the Northeastern United States. It borders the Atlantic Ocean and the Gulf of Maine to its east, Connecticut and Rhode Island to its south, New Hampshire and Vermont to its north, and New York (state), New York to its west. Massachusetts is the List of U.S. states and territories by area, sixth-smallest state by land area. With a 2024 U.S. Census Bureau-estimated population of 7,136,171, its highest estimated count ever, Massachusetts is the most populous state in New England, the List of U.S. states and territories by population, 16th-most-populous in the United States, and the List of states and territories of the United States by population density, third-most densely populated U.S. state, after New Jersey and Rhode Island. Massachusetts was a site of early British colonization of the Americas, English colonization. The Plymouth Colony was founded in 16 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hampshire College Alumni
Hampshire (, ; abbreviated to Hants.) is a ceremonial county in South East England. It is bordered by Berkshire to the north, Surrey and West Sussex to the east, the Isle of Wight across the Solent to the south, Dorset to the west, and Wiltshire to the north-west. Southampton is the largest settlement, while Winchester is the county town. Other significant settlements within the county include Portsmouth, Basingstoke, Andover, Gosport, Fareham and Aldershot. The county has an area of and a population of 1,844,245, making it the 5th-most populous in England. The South Hampshire built-up area in the south-east of the county has a population of 855,569 and contains the cities of Southampton (269,781) and Portsmouth (208,100). In the north-east, the Farnborough/Aldershot conurbation extends into Berkshire and Surrey and has a population of 252,937. The next-largest settlements are Basingstoke (113,776), Andover (50,887), and Winchester (45,184). The centre and south-west of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Year Of Birth Missing (living People)
A year is a unit of time based on how long it takes the Earth to orbit the Sun. In scientific use, the tropical year (approximately 365 solar days, 5 hours, 48 minutes, 45 seconds) and the sidereal year (about 20 minutes longer) are more exact. The modern calendar year, as reckoned according to the Gregorian calendar, approximates the tropical year by using a system of leap years. The term 'year' is also used to indicate other periods of roughly similar duration, such as the lunar year (a roughly 354-day cycle of twelve of the Moon's phasessee lunar calendar), as well as periods loosely associated with the calendar or astronomical year, such as the seasonal year, the fiscal year, the academic year, etc. Due to the Earth's axial tilt, the course of a year sees the passing of the seasons, marked by changes in weather, the hours of daylight, and, consequently, vegetation and soil fertility. In temperate and subpolar regions around the planet, four seasons a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Panagrellus Redivivus
The free-living nematode ''Panagrellus redivivus'' (sour paste nematode, or beer mat nematode from its occurrence in constantly moist felt beer mats), is known to many aquarium enthusiasts and fish keepers as the microworm. It is a tiny roundworm used as the first food for larger kinds of newly-hatched fish, such as larval common carp. The microworm is widely used in aquaculture as food for a variety of fish and crustacean species. One of thirteen currently recognized species of ''Panagrellus'', ''P. redivivus'' is about 50 μm in diameter and just over 1 mm in length, barely visible to the naked eye. Subsisting on yeast, it is easily cultured at home on a substrate of flour paste or porridge inoculated with dry yeast. Females reach maturity in about three days and deliver live young rather than eggs, as most nematodes produce. The microworm has been used in genetic analysis studies, but not nearly as universally as its relative, ''Caenorhabditis elegans ''Caenorhabdi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autism
Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing differences, focused interests, and repetitive behaviors, which may include stimming. Formal diagnosis requires significant challenges in multiple domains of life, with characteristics that are atypical or more pronounced than expected for one's age and sociocultural context.(World Health Organization: International Classification of Diseases version 11 (ICD-11)): https://icd.who.int/browse/2024-01/mms/en#437815624 Motor coordination difficulties are common but not required for diagnosis. Autism is a spectrum disorder, resulting in wide variations in presentation and support needs, such as that between speaking and non-speaking populations. Increased estimates of autism prevalence since the 1990s are primarily attributed to broader c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Model Organism
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution. Research using animal models has been central to most of the achievements of modern medicine. It has contributed most of the basic knowledge in fields such as human physiology and biochemistry, and has played significant roles in fields such as neuroscience and infectious disease. The results have included the near- eradication of polio and the development of organ transplantation, and have benefited both humans and animals. From 19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Ontology Consortium
The Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access to all aspects of the data provided by the project, and to enable functional interpretation of experimental data using the GO, for example via enrichment analysis. GO is part of a larger classification effort, the Open Biomedical Ontologies, being one of the Initial Candidate Members of the OBO Foundry. Whereas gene nomenclature focuses on gene and gene products, the Gene Ontology focuses on the function of the genes and gene products. The GO also extends the effort by using a markup language to make the data (not only of the genes and their products but also of curated attributes) machine rea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis
''Caenorhabditis'' is a genus of nematodes which live in bacteria-rich environments like compost piles, decaying dead animals and rotting fruit. The name comes from Greek: caeno- ( () = new, recent); rhabditis = rod-like ( () = rod, wand). The genus ''Caenorhabditis'' contains the noted model organism ''Caenorhabditis elegans'' and several other species for which a genome sequence is either available or currently being determined. The two most-studied species in this genus (''C. elegans'' and ''C. briggsae'') are both androdioecy, androdioecious (they have male and hermaphrodite sexes) whereas most other species are gonochoristic (they have male and female sexes). ''C. elegans'' is the type species of the genus. In 1900, Émile Maupas, Maupas initially named the species ''Rhabditidae, Rhabditis elegans'', Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. Ecology ''Caenorhabditis'' occupy various ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
