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Paul Hardin (chronobiologist)
Paul Hardin (born September 14, 1960) is a prominent scientist in the field of chronobiology and a pioneering researcher in the understanding of circadian clocks in flies and mammals. Hardin currently serves as a distinguished professor in the biology department at Texas A&M University. He is best known for his discovery of circadian oscillations in the mRNA of the clock gene Period (''per''), the importance of the E-Box in ''per'' activation, the interlocked feedback loops that control rhythms in activator gene transcription, and the circadian regulation of olfaction in ''Drosophila melanogaster''. Born in a suburb of Chicago, Matteson, Illinois, Hardin currently resides in College Station, Texas, with his wife and three children. Academic career Hardin earned his B.S. in biology at Southern Methodist University (SMU) in 1982. He then continued to pursue a Ph.D in genetics from Indiana University in 1987 with William H. Klein. He went on to conduct his postdoctoral research at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hazel Crest
Hazel Crest is a village in Cook County, Illinois, United States. The population was 13,382 at the 2020 census. History Hazel Crest was first settled in 1870 in a farming community known as South Harvey. An enterprising newspaper editor named William McClintock moved here from Ohio in 1890, buying from farmer Fred Puhrman. McClintock built a depot for a local milk train and subsequently opened transportation opportunities to Chicago and beyond. The depot also served as the area's first real estate office, public meeting place, Sunday school, day school, and post office. In 1900, the name was changed to Hazel Crest to reflect the large numbers of hazelnut bushes that grew on a rise of land just south of town. At the time, the southern border was 175th Street and the western edge of the village was Kedzie Avenue. Hazel Crest was incorporated in 1912. Many of the families of the early residents still live in the village. Over the years, significant developments have occurred b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription (biology)
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA ( Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA. Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Transcription proceeds in the following general steps: # RNA polymerase, together with one or more general transcription factors, binds to promoter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
E-box
An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues. Its specific DNA sequence, CANNTG (where N can be any nucleotide), with a palindromic canonical sequence of CACGTG, is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the promoters through the E-box, other enzymes can bind to the promoter and facilitate transcription from DNA to mRNA. Discovery The E-box was discovered in a collaboration between Susumu Tonegawa's and Walter Gilbert's laboratories in 1985 as a control element in immunoglobulin heavy-chain enhancer. They found that a region of 140 base pairs in the tissue-specific transcriptional enhancer element was sufficient for different levels of transcription enhancement in different tissues and sequences. They suggested that proteins made by specific tissues act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enhancer (genetics)
In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins ( activators) to increase the likelihood that transcription of a particular gene will occur. These proteins are usually referred to as transcription factors. Enhancers are ''cis''-acting. They can be located up to 1 Mbp (1,000,000 bp) away from the gene, upstream or downstream from the start site. There are hundreds of thousands of enhancers in the human genome. They are found in both prokaryotes and eukaryotes. The first discovery of a eukaryotic enhancer was in the immunoglobulin heavy chain gene in 1983. This enhancer, located in the large intron, provided an explanation for the transcriptional activation of rearranged Vh gene promoters while unrearranged Vh promoters remained inactive. Locations In eukaryotic cells the structure of the chromatin complex of DNA is folded in a way that functionally mimics the supercoiled state characteristic of prokaryotic DNA, so although the en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 '' Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California Institute Of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasionally referred to as "CIT", most notably in its alma mater, but this is uncommon. is a private university, private research university in Pasadena, California. Caltech is ranked among the best and most selective academic institutions in the world, and with an enrollment of approximately 2400 students (acceptance rate of only 5.7%), it is one of the world's most selective universities. The university is known for its strength in science and engineering, and is among a small group of Institute of Technology (United States), institutes of technology in the United States which is primarily devoted to the instruction of pure and applied sciences. The institution was founded as a preparatory and vocational school by Amos G. Throop in 1891 and began ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ron Konopka
Ronald J. Konopka (1947-2015) was an American geneticist who studied chronobiology. He made his most notable contribution to the field while working with ''Drosophila'' in the lab of Seymour Benzer at the California Institute of Technology. During this work, Konopka discovered the '' period'' (''per'') gene, which controls the period of circadian rhythms. Academic career Ron Konopka received his Ph.D. in Biology from the California Institute of Technology in 1972. In 1975, following his discovery of the ''period'' mutants, Konopka was awarded a faculty position at the California Institute of Technology. While there, Konopka's colleagues were critical of his reluctance to publish his work on the ''period'' gene, and Konopka was denied tenure. After his stay at Caltech, Konopka accepted a position at Clarkson University but was again denied tenure and subsequently exited the field of science. Konopka's career, interwoven with the work of his mentor, Seymour Benzer, and the other sci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Society For Research On Biological Rhythms
The Society for Research on Biological Rhythms (SRBR) is an international chronobiological research society with three key goals: (1) to promote the advancement and dissemination of basic and applied research in all aspects of biological rhythms (2) to enhance the education and training of students and researchers in the field (3) to foster interdisciplinary communication and an international exchange of ideas. The society holds biennial meetings and informal gatherings, and participates in peer-reviewed science and evidence-based policy making. It is one of four prominent existing Chronology Research Societies and one of the 14 societies that make up ''The World Federation of Societies for Chronobiology''. The organization is currently composed of 1,000 scientists and clinicians dedicated to studying biological rhythms and their impact. The society has its own official journal, the Journal of Biological Rhythms. Through its journal and meetings the society engages scientists of all ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biology
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments. Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations.Based on definition from: Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
College Station, Texas
College Station is a city in Brazos County, Texas, situated in East-Central Texas in the heart of the Brazos Valley, towards the eastern edge of the region known as the Texas Triangle. It is northwest of Houston and east-northeast of Austin. As of the 2020 census, College Station had a population of 120,511. College Station and Bryan make up the Bryan-College Station metropolitan area, the 13th-largest metropolitan area in Texas with 273,101 people as of 2019. College Station is home to the main campus of Texas A&M University, the flagship institution of the Texas A&M University System. The city owes its name and existence to the university's location along a railroad. Texas A&M's triple designation as a Land-, Sea-, and Space-Grant institution reflects the broad scope of the research endeavors it brings to the city, with ongoing projects funded by agencies such as NASA, the National Institutes of Health, the National Science Foundation, and the Office of Naval Research. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matteson, Illinois
Matteson () is a village in Cook County, Illinois, United States. The population was 19,073 at the 2020 census. It is a suburb of Chicago. History The area encompassed by modern Matteson was settled in the late 1800s, primarily by people of German descent. Platted in 1855, Matteson had nearly 500 residents when it incorporated as a village in 1889. The village's namesake is Joel Aldrich Matteson, who served as Illinois' tenth governor from 1853 to 1857. The 20th century saw improvements in plumbing, the electrification of the Illinois Central Railroad, and the construction of today's school district, resulting in significant population growth to more than 3,000 residents by the end of the 1960s. By 2000, Matteson was home to Lincoln Mall (opened 1973) and annexed 195 acres of land for the village. Today, Matteson is home to nearly 20,000 residents, hundreds of businesses, and the close proximity of two major hospitals, Matteson offer the best of suburban living. Matteson features ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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