|
Paul C Zamecnik
Paul Charles Zamecnik (November 22, 1912 – October 27, 2009) was an American scientist who played a central role in the early history of molecular biology. He was a professor of medicine at Harvard Medical School and a senior scientist at Massachusetts General Hospital. Zamecnik pioneered the in vitro synthesis of proteins and helped elucidate the way cells generate proteins. With Mahlon Hoagland he co-discovered transfer RNA (tRNA). Through his later work, he is credited as the inventor of antisense therapeutics. Throughout his career, Zamecnik earned over a dozen US patents for his therapeutic techniques. Up until his death in 2009 he maintained a lab at MGH where he studied the application of synthetic oligonucleotides (antisense hybrids) for chemotherapeutic treatment of drug resistant and XDR tuberculosis in his later years. Early life Paul Zamecnik was born in Cleveland, Ohio to John Charles Zamecnik (1879-1930) and Mary Gertrude Mccarthy (1883-1937). John's first cou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cleveland, Ohio
Cleveland is a city in the U.S. state of Ohio and the county seat of Cuyahoga County, Ohio, Cuyahoga County. Located along the southern shore of Lake Erie, it is situated across the Canada–United States border, Canada–U.S. maritime border and approximately west of the Ohio-Pennsylvania state border. Cleveland is the most populous city on Lake Erie, the list of cities in Ohio, second-most populous city in Ohio, and the List of United States cities by population, 53rd-most populous city in the U.S. with a population of 372,624 in 2020. The city anchors the Greater Cleveland, Cleveland metropolitan area, the Metropolitan statistical area, 33rd-largest in the U.S. at 2.18 million residents, as well as the larger Cleveland–Akron, Ohio, Akron–Canton, Ohio, Canton combined statistical area with 3.63 million residents. Cleveland was founded in 1796 near the mouth of the Cuyahoga River as part of the Connecticut Western Reserve in modern-day Northeast Ohio by General Moses Clea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zoology
Zoology ( , ) is the scientific study of animals. Its studies include the anatomy, structure, embryology, Biological classification, classification, Ethology, habits, and distribution of all animals, both living and extinction, extinct, and how they interact with their ecosystems. Zoology is one of the primary branches of biology. The term is derived from Ancient Greek , ('animal'), and , ('knowledge', 'study'). Although humans have always been interested in the natural history of the animals they saw around them, and used this knowledge to domesticate certain species, the formal study of zoology can be said to have originated with Aristotle. He viewed animals as living organisms, studied their structure and development, and considered their adaptations to their surroundings and the function of their parts. Modern zoology has its origins during the Renaissance and early modern period, with Carl Linnaeus, Antonie van Leeuwenhoek, Robert Hooke, Charles Darwin, Gregor Mendel a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antisense Therapy
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through Splicing (genetics), splicing site binding on pre-mRNA. Several ASOs have been approved in the United States, the European Union, and elsewhere. Nomenclature The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense oligonucleotides. Antisense Oligonucleotide Development Developments in ASO modification are separated into three generations. Generation one is called backbone-modified and focuses on the phosphodiester group of the nucleotide. This impacts inter-nucleotide binding. These modifications led to better distribution, reduced urinary excretion, and prolonged residence time of the ASOs in the cell. Some exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Massachusetts Medical School
The UMass Chan Medical School is a public medical school in Worcester, Massachusetts. It is part of the University of Massachusetts system. It consists of three schools: the T.H. Chan School of Medicine, the Morningside Graduate School of Biomedical Sciences, and the Tan Chingfen Graduate School of Nursing. The school also operates a biomedical research enterprise and a range of public-service initiatives throughout the state. History The University of Massachusetts Medical School (UMMS) was established by the 162nd Massachusetts General Court in 1962 to provide residents of the commonwealth an opportunity to study medicine at an affordable cost and to increase the number of primary-care physicians practicing in the commonwealth's under-served areas. The legislation was signed into law by Massachusetts Governor John Volpe. The School of Medicine accepted its first class of 16 students in 1970. Six years later a 371-bed hospital opened on campus; the Graduate School of Biomed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Worcester Foundation For Biomedical Research
The Worcester Foundation for Biomedical Research (WFBR) was a non-profit biomedical research institute based in Shrewsbury, Massachusetts, United States. History The foundation was established as an independent research center under the name Worcester Foundation for Experimental Biology (WFEB) in 1944 by Hudson Hoagland and Gregory Pincus. It was best known for the development of the combined oral contraceptive pill by Pincus and Min Chueh Chang, an important development in modern birth control, and for pioneering research on ''in vitro'' fertilization by Chang. In the 1970s, WFEB scientists undertook the first systematic study of anti-tumor effects of the anti-estrogen tamoxifen led by 2003 Kettering Prize recipient V. Craig Jordan and initial studies of aromatase inhibitors by 2005 Kettering prize recipient Angela Brodie, two important classes of drugs to treat breast cancer. In the 1950s and 1960s, the WFEB sponsored a Pre-Collegiate Science Summer Program, similar to, but sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Bergmann
Max Bergmann (12 February 1886 – 7 November 1944) was a Jewish- German biochemist. Together with Leonidas Zervas, the discoverer of the group, they were the first to use the carboxybenzyl protecting group for the synthesis of oligopeptides. Life and work Bergmann was born in Fürth, Bavaria, Germany on February 12, 1886, the seventh child of coal wholesalers Salomon and Rosalie Bergmann. Bergmann started studying Biology at the Ludwig Maximilian University of Munich, but lectures by Adolf von Baeyer captured his interest and eventually persuaded him to switch to Organic Chemistry. He continued his chemical studies at the Friedrich Wilhelm University of Berlin, where he was taught by Emil Fischer. After receiving his PhD under the supervision of Ignaz Bloch de">:de:Ignaz Bloch">de/small> in 1911 for his thesis on acyl(polysulfides), he became the assistant to Fischer at the University of Berlin, where he stayed until Fischer's death in 1919. He received his habilitation i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Institute For Medical Research
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified as a "Special Focus – Research Institution". Rockefeller is the oldest biomedical research institute in the United States. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine'', the ''Journal of Cell Biology'', and ''The Journal of General Physiology''. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Charles Aub
Joseph Charles Aub (1890-1973) was an American endocrinologist and professor then chair of medicine at Harvard University. He graduated from Harvard College and Harvard Medical School. The lead industry funded Aub's research which ignored the health effects of lead on children. Honours and awards Foreign honours * : Officer of the Order of the White Lion The Order of the White Lion () is the highest order of the Czech Republic. It continues a Czechoslovak order of the same name created in 1922 as an award for foreigners (Czechoslovakia having no civilian decoration for its citizens in the 192 ... (1946) References External links Joseph C. Aub papers, 1918-1974. H MS c169, Harvard Medical Library, Francis A. Countway Library of Medicine, Boston, Mass. 1890 births 1973 deaths American endocrinologists Harvard Medical School alumni Members of the United States National Academy of Sciences Officers of the Order of the White Lion {{US-physician-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Office Of Scientific Research And Development
The Office of Scientific Research and Development (OSRD) was an agency of the United States federal government created to coordinate scientific research for military purposes during World War II. Arrangements were made for its creation during May 1941, and it was created formally by Executive Order 8807 on June 28, 1941. It superseded the work of the National Defense Research Committee (NDRC), was given almost unlimited access to funding and resources, and was directed by Vannevar Bush, who reported only to President Franklin Delano Roosevelt. The research was widely varied, and included projects devoted to new and more accurate bombs, reliable detonators, work on the proximity fuze, guided missiles, radar and early-warning systems, lighter and more accurate hand weapons, more effective medical treatments (including work to make penicillin at scale, which was necessary for its use as a drug), more versatile vehicles, and, the most secret of all, the S-1 Section, which later becam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Traumatic Shock
Shock is the state of insufficient blood flow to the tissues of the body as a result of problems with the circulatory system. Initial symptoms of shock may include weakness, tachycardia, hyperventilation, sweating, anxiety, and increased thirst. This may be followed by confusion, unconsciousness, or cardiac arrest, as complications worsen. Shock is divided into four main types based on the underlying cause: hypovolemic, cardiogenic, obstructive, and distributive shock. Hypovolemic shock, also known as low volume shock, may be from bleeding, diarrhea, or vomiting. Cardiogenic shock may be due to a heart attack or cardiac contusion. Obstructive shock may be due to cardiac tamponade or a tension pneumothorax. Distributive shock may be due to sepsis, anaphylaxis, injury to the upper spinal cord, or certain overdoses. The diagnosis is generally based on a combination of symptoms, physical examination, and laboratory tests. A decreased pulse pressure (systolic blood pressure minu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World War II
World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the world's countries participated, with many nations mobilising all resources in pursuit of total war. Tanks in World War II, Tanks and Air warfare of World War II, aircraft played major roles, enabling the strategic bombing of cities and delivery of the Atomic bombings of Hiroshima and Nagasaki, first and only nuclear weapons ever used in war. World War II is the List of wars by death toll, deadliest conflict in history, causing World War II casualties, the death of 70 to 85 million people, more than half of whom were civilians. Millions died in genocides, including the Holocaust, and by massacres, starvation, and disease. After the Allied victory, Allied-occupied Germany, Germany, Allied-occupied Austria, Austria, Occupation of Japan, Japan, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
