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Paul A. Hopper
Paul A. Hopper (born 1956) is an Australian bioentrepreneur who has been associated since 2003 with a number of biotechnology companies, most of them publicly traded. Background Born in PNG to a prominent post WW2 Australian colonial family, Hopper was educated in Sydney at the King's School, Parramatta and subsequently received a Bachelor of Arts degree majoring in Political Science from the University of New South Wales. In 1988 he cofounded Alpha Healthcare, an Australian private hospital group based in Sydney where was managing director until 1999. He began his career as a bioentrepreneur in the early 2000s. Australian Cancer Technology, 2003–2005 Hopper's first biotechnology company was the ASX-listed Australian Cancer Technology Ltd, where he was CEO based in Sydney from September 2003 to February 2005. Among the drugs which Australian Cancer Technology worked on during this period was RP101, a small molecule which, by binding to heat shock protein 27 (Hsp27), was d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroblast
A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, produces the structural framework ( stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals. Structure Fibroblasts have a branched cytoplasm surrounding an elliptical, speckled nucleus having two or more nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum. Inactive fibroblasts (called fibrocytes) are smaller, spindle-shaped, and have a reduced amount of rough endoplasmic reticulum. Although disjointed and scattered when they have to cover a large space, fibroblasts, when crowded, often locally align in parallel clusters. Unlike the epithelial cells lining the body structures, fibroblasts do not form flat monolayers and are not restricted by a polarizing attachment to a basal lamina on one side, although they may contribute to basal lamina components in so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1956 Births
Events January * January 1 – The Anglo-Egyptian Condominium ends in Sudan. * January 8 – Operation Auca: Five U.S. evangelical Christian missionaries, Nate Saint, Roger Youderian, Ed McCully, Jim Elliot and Pete Fleming, are killed for trespassing by the Huaorani people of Ecuador, shortly after making contact with them. * January 16 – Egyptian leader Gamal Abdel Nasser vows to reconquer Palestine. * January 25– 26 – Finnish troops reoccupy Porkkala, after Soviet troops vacate its military base. Civilians can return February 4. * January 26 – The 1956 Winter Olympics open in Cortina d'Ampezzo, Italy. February * February 11 – British spies Guy Burgess and Donald Maclean resurface in the Soviet Union, after being missing for 5 years. * February 14– 25 – The 20th Congress of the Communist Party of the Soviet Union is held in Moscow. * February 16 – The 1956 World Figure Skating Championships open in Garmisch, West Germany. * February 22 – Elvis P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Australian Business Executives
Australian(s) may refer to: Australia * Australia, a country * Australians, citizens of the Commonwealth of Australia ** European Australians ** Anglo-Celtic Australians, Australians descended principally from British colonists ** Aboriginal Australians, indigenous peoples of Australia as identified and defined within Australian law * Australia (continent) ** Indigenous Australians * Australian English, the dialect of the English language spoken in Australia * Australian Aboriginal languages * ''The Australian'', a newspaper * Australiana, things of Australian origins Other uses * Australian (horse), a racehorse * Australian, British Columbia Australian is an historic unincorporated community on the Fraser River in the Cariboo Country of the Central Interior of British Columbia, Canada. Its name is derived from that of the Australian Ranch, one of British Columbia's first ranching oper ..., an unincorporated community in Canada See also * The Australian (other) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glioblastoma
Glioblastoma, previously known as glioblastoma multiforme (GBM), is one of the most aggressive types of cancer that begin within the brain. Initially, signs and symptoms of glioblastoma are nonspecific. They may include headaches, personality changes, nausea, and symptoms similar to those of a stroke. Symptoms often worsen rapidly and may progress to unconsciousness. The cause of most cases of glioblastoma is not known. Uncommon risk factors include genetic disorders, such as neurofibromatosis and Li–Fraumeni syndrome, and previous radiation therapy. Glioblastomas represent 15% of all brain tumors. They can either start from normal brain cells or develop from an existing low-grade astrocytoma. The diagnosis typically is made by a combination of a CT scan, MRI scan, and tissue biopsy. There is no known method of preventing the cancer. Treatment usually involves surgery, after which chemotherapy and radiation therapy are used. The medication temozolomide is frequently use ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prescient Therapeutics
Prescient Therapeutics Ltd is a clinical stage oncology company. The company is focused on the development of a universal CAR-T platform (OmniCAR), enhanced CAR-T cell manufacturing & function (CellPryme) and on two small molecule drug targeted therapies (PTX-100 & PTX-200). History Prescient Therapeutics Ltd (Prescient) was created in 2014 by bringing together two small molecule drug assets from separate US private companies (Pathway Oncology for PTX-100 and AKTivate Therapeutics for PTX-200) into the existing ASX-listed company Virax Holdings Ltd (Virax). Virax had been previously unsuccessful in developing a viral delivery of immunologic genes for the treatment of HIV. Paul Hopper, an Australian bio-entrepreneur, looking to access public markets to help develop the PTX-100 & PTX-200 assets, helped coordinate sequential reverse takeovers wherein Virax first acquired Pathway Oncology (deal announced 17 March 2014, completed 30 May 2014) and then AKTivate Therapeutics (deal a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncolytic Virus
An oncolytic virus is a virus that preferentially infects and kills cancer cells. As the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses. Oncolytic viruses also have the ability to affect the tumor micro-environment in multiples ways. The potential of viruses as anti-cancer agents was first realised in the early twentieth century, although coordinated research efforts did not begin until the 1960s. A number of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus, and vaccinia have been clinically tested as oncolytic agents. Most current oncolytic viruses are engineered for tumour selectivity, although there are naturally occurring examples such as reovirus and the senecavirus, resulting in clinical trial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viralytics
Viralytics Ltd is an Australian biotechnology company working in the field of oncolytic viruses, that is, viruses that preferentially infect and kill cancer cells. The company's oncolytic virus product, called Cavatak, is currently in clinical trials in metastatic melanoma and other cancers. The drug was granted Orphan Drug status in advanced melanoma in December 2005. Corporate history Around 1999 a team led by the virologist Professor Darren Shafren at the University of Newcastle in Australia established that a Coxsackievirus called Coxsackievirus A21 was an oncolytic virus, in addition to being a common-cold virus causing mild upper respiratory tract infections. Shafren filed for patent protection over the use of the virus in oncology and the University of Newcastle subsequently formed a spin-out company called ViroTarg Pty Ltd. An ASX-listed biotech company called Psiron began to fund development of the ViroTarg project in June 2004 and in December 2006 acquired the Virota ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Immunotherapy
Cancer immunotherapy (sometimes called immuno-oncology) is the stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight the disease. It is an application of the fundamental research of cancer immunology and a growing subspecialty of oncology. Cancer immunotherapy exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them. The tumor antigens are often proteins or other macromolecules (e.g., carbohydrates). Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. Clinical success of cancer immunotherapy is highly variable between different forms of cancer; for instance, certain subtypes of gastric cancer react well to the approach whereas immunotherapy is not effective for othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imugene
Imugene Ltd is a clinical stage immuno-oncology company developing a range of new and novel immunotherapies that seek to activate the immune system of cancer patients to treat and eradicate tumours. Imugene's unique platform technologies seeks to harness the body's immune system against tumours, potentially achieving a similar or greater effect than synthetically manufactured monoclonal antibody and other immunotherapies. The company's product pipeline includes multiple immunotherapy B-cell vaccine candidates and an oncolytic virotherapy (CF33) aimed at treating a variety of cancers in combination with standard of care drugs and emerging immunotherapies such as CAR T's for solid tumours. Imugene is a publicly traded company, listed on the Australian Securities Exchange (ASX) under the code IMU. In December 2021 it entered the S&P/ASX 200 Index, in effect making it one of the 200 largest companies on the ASX. History Imugene began as a research project in the laboratory of P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parathyroid Hormone
Parathyroid hormone (PTH), also called parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands that regulates the serum calcium concentration through its effects on bone, kidney, and intestine. PTH influences bone remodeling, which is an ongoing process in which bone tissue is alternately resorbed and rebuilt over time. PTH is secreted in response to low blood serum calcium (Ca2+) levels. PTH indirectly stimulates osteoclast activity within the bone matrix ( osteon), in an effort to release more ionic calcium (Ca2+) into the blood to elevate a low serum calcium level. The bones act as a (metaphorical) "bank of calcium" from which the body can make "withdrawals" as needed to keep the amount of calcium in the blood at appropriate levels despite the ever-present challenges of metabolism, stress, and nutritional variations. PTH is "a key that unlocks the bank vault" to remove the calcium. PTH is secreted primarily by the chief cells of the para ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
King's School, Parramatta
The King's School is an Education in Australia#Non-government schools, independent Anglican Church of Australia, Anglican, Pre-school education, early learning, primary school, primary and secondary school, secondary day and boarding school, boarding school for boys, located in North Parramatta, New South Wales, North Parramatta in the western suburbs of Sydney, New South Wales, Australia. Founded in 1831, the school is Australia's oldest independent school, and is situated on a suburban campus. The School has about 2,100 students from kindergarten to Year 12 and about 430 boarders from Years 5–12, making it one of the largest boarding schools in Australia. It is Australia's oldest boarding school. The school is affiliated with the Headmasters' and Headmistresses' Conference, the Association of Heads of Independent Schools of Australia (AHISA), the Junior School Heads Association of Australia (JSHAA), and the Australian Boarding Schools' Association (ABSA). It is a G30 Schools, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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