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Patrick Girondi
Patrick Girondi is an Italian-American singer, composer and pharmaceutical executive/ patient advocate. He is the founder and CEO of San Rocco Therapeutics. Early life Patrick Girondi was born and named Patrick Michael Finley in Chicago, Illinois. He later took his mothers’ maiden name, "Girondi" in 1985. He was a high school dropout . Career Singing Patrick Girondi has been a singer-songwriter, performing since the age of six. In 1998, Girondi and Ken Barnard of Street Factory Music began honing his singing and songwriting skills. His first commercial single, "Colpo Di Cuore" was released on Street Factory Records in 2002. It also appeared on his debut CD, ''Orphan’s Soul''. Girondi's sophomore release, ''Orphan’s Journey'', appeared in the musical score of the Italian film, ''Focaccia Blues''. ''Orphan’s Journey'' earned him the "International Indie Artist of The Year Award" in 2007, as voted by the Indie Music Writers Association. Subsequent albums include: ''Orph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chicago
(''City in a Garden''); I Will , image_map = , map_caption = Interactive Map of Chicago , coordinates = , coordinates_footnotes = , subdivision_type = List of sovereign states, Country , subdivision_name = United States , subdivision_type1 = U.S. state, State , subdivision_type2 = List of counties in Illinois, Counties , subdivision_name1 = Illinois , subdivision_name2 = Cook County, Illinois, Cook and DuPage County, Illinois, DuPage , established_title = Settled , established_date = , established_title2 = Municipal corporation, Incorporated (city) , established_date2 = , founder = Jean Baptiste Point du Sable , government_type = Mayor–council government, Mayor–council , governing_body = Chicago City Council , leader_title = Mayor of Chicago, Mayor , leader_name = Lori Lightfo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Claudio Baglioni
Claudio Baglioni (; born 16 May 1951) is an Italian pop singer-songwriter and musician. His career has been going on for over 50 years. Some songs from the 70s are part of Italian culture such as ''E tu come stai?''. In the 80s he released the two best-selling albums ever in Italy ''Strada facendo'' and ''La vita è adesso''. And in the 90's he embraced World Music with records like '' Oltre'' and ''Io sono qui.'' In 2006 he composed the anthem of the 2006 Winter Olympics. Biography Around 1968 he composed the ''Annabel Lee'' musical suite, based on a poem by Edgar Allan Poe. In 1969, he released his first single and recorded the single ''Signora Lia''; a comic song that tells of a lady's marital infidelity, over time the song will become a cult of Italian pop music despite its poor initial success. He collaborated with Italian singer Mia Martini for her debut album. Success came only in 1972, with the album ''Questo piccolo grande amore''; the homonymous song in 1985 will be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michele Placido
Michele Placido (; born 19 May 1946) is an Italian actor, film director, and screenwriter. He began his career on stage, and first gained mainstream attention through a series of roles in films directed by the likes of Mario Monicelli and Marco Bellocchio, winning the Berlinale's Silver Bear for Best Actor for his performance in the 1979 film ''Ernesto''. He is known internationally for portraying police inspector Corrado Cattani on the crime drama television series '' La piovra'' (1984–2001). Placido's directorial debut, '' Pummarò'', was screened Un Certain Regard at the 1990 Cannes Film Festival. Three of his films have competed for the Golden Lion at the Venice Film Festival. He is a five-time Nastro d'Argento and four-time David di Donatello winner. In 2021, Placido was appointed President of the Teatro Comunale in Ferrara. Early life Placido was born at Ascoli Satriano, into a poor family from Rionero in Vulture, Basilicata; he is a descendant of the known brigan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Oprah Winfrey Show
''The Oprah Winfrey Show'', often referred to as ''The Oprah Show'' or simply ''Oprah'', is an American daytime broadcast syndication, syndicated talk show that aired nationally for 25 seasons from September 8, 1986, to May 25, 2011, in Chicago, Chicago, Illinois. Produced and hosted by Oprah Winfrey, it remains the highest-rated daytime talk show in American television history. The show was highly influential to many young stars, and many of its themes have penetrated into the American pop-cultural consciousness. Winfrey used the show as an educational platform, featuring book clubs, interviews, self-improvement segments, and philanthropic forays into world events. The show did not attempt to profit off the products it endorses; it had no licensing agreement with retailers when products were promoted, nor did the show make any money from endorsing books for its book club. ''Oprah'' was one of the longest-running daytime television talk shows in history. The show received 47 D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thalassemia
Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children. Thalassemias are genetic disorders inherited from a person's parents. There are two main types, alpha thalassemia and beta thalassemia. The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing. Diagnosis is typically by blood tests including a complete blood count, special hemoglobin tests, and genetic tests. Diagnosis may occur before birth through prenatal testing. Treatment depends on the type and severity. Treatment for those with more severe disease often includes regular blood transfusions, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sickle-cell Disease
Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances. Problems in sickle cell disease typically begin around 5 to 6 months of age. A number of health problems may develop, such as attacks of pain (known as a sickle cell crisis), anemia, swelling in the hands and feet, bacterial infections and stroke. Long-term pain may develop as people get older. The average life expectancy in the developed world is 40 to 60 years. Sickle cell disease occurs when a person inherits two abnormal copies of the β-globin gene (''HBB'') that makes haemoglobin, one from each parent. This gene occurs in chromosome 11. Several subtypes exist, depending on the exact mutation in each haemoglobin gene. An attack can be set off by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Therapy
Gene therapy is a medical field which focuses on the genetic modification of cells to produce a therapeutic effect or the treatment of disease by repairing or reconstructing defective genetic material. The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. It is thought to be able to cure many genetic disorders or treat them over time. Between 1989 and December 2018, over 2,900 clinical trials were conducted, with more than half of them in phase I.Gene Therapy Cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John T
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died c. AD 30), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (lived c. AD 30), one of the twelve apostles of Jesus * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Europe
Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a subcontinent of Eurasia and it is located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. Comprising the westernmost peninsulas of Eurasia, it shares the continental landmass of Afro-Eurasia with both Africa and Asia. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south and Asia to the east. Europe is commonly considered to be separated from Asia by the watershed of the Ural Mountains, the Ural River, the Caspian Sea, the Greater Caucasus, the Black Sea and the waterways of the Turkish Straits. "Europe" (pp. 68–69); "Asia" (pp. 90–91): "A commonly accepted division between Asia and Europe ... is formed by the Ural Mountains, Ural River, Caspian Sea, Caucasus Mountains, and the Blac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wall Street Journal
''The Wall Street Journal'' is an American business-focused, international daily newspaper based in New York City, with international editions also available in Chinese and Japanese. The ''Journal'', along with its Asian editions, is published six days a week by Dow Jones & Company, a division of News Corp. The newspaper is published in the broadsheet format and online. The ''Journal'' has been printed continuously since its inception on July 8, 1889, by Charles Dow, Edward Jones, and Charles Bergstresser. The ''Journal'' is regarded as a newspaper of record, particularly in terms of business and financial news. The newspaper has won 38 Pulitzer Prizes, the most recent in 2019. ''The Wall Street Journal'' is one of the largest newspapers in the United States by circulation, with a circulation of about 2.834million copies (including nearly 1,829,000 digital sales) compared with ''USA Today''s 1.7million. The ''Journal'' publishes the luxury news and lifestyle magazine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simon And Schuster
Simon & Schuster () is an American publishing company and a subsidiary of Paramount Global. It was founded in New York City on January 2, 1924 by Richard L. Simon and M. Lincoln Schuster. As of 2016, Simon & Schuster was the third largest publisher in the United States, publishing 2,000 titles annually under 35 different imprints. History Early years In 1924, Richard Simon's aunt, a crossword puzzle enthusiast, asked whether there was a book of ''New York World'' crossword puzzles, which were very popular at the time. After discovering that none had been published, Simon and Max Schuster decided to launch a company to exploit the opportunity.Frederick Lewis Allen, ''Only Yesterday: An Informal History of the 1920s'', p. 165. . At the time, Simon was a piano salesman and Schuster was editor of an automotive trade magazine. They pooled , equivalent to $ today, to start a company that published crossword puzzles. The new publishing house used "fad" publishing to publish boo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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