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Paramethoxyamphetamine
''para''-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or entactogen effects, and behaves more like an antidepressant in comparison, though it does have some psychedelic properties. PMA has been found in tablets touted as MDMA (ecstasy) although its effects are markedly different compared to those of MDMA. The consequences of such deception have often included hospitalization and death for unwitting users. PMA is commonly synthesized from anethole, the flavor compound of anise and fennel, mainly because the starting material for MDMA, safrole, has become less available due to law enforcement action, causing illicit drug manufacturers to use anethole as an alternative. Effects According to Alexander Shulgin in ''PiHKAL'', the effects of PMA at doses of 50 to 80mg included hypertension, diethyltrypt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PiHKAL
''PiHKAL: A Chemical Love Story'' is a book by Alexander Shulgin and Ann Shulgin published in 1991. The subject of the work is Psychoactive drug, psychoactive phenethylamine Derivative (chemistry), chemical derivatives, notably those that act as psychedelic drug, psychedelics and/or empathogen-entactogens. The main title, PiHKAL, is an acronym that stands for "Phenethylamines I Have Known and Loved". The book is arranged into two parts, the first part being a fictionalized autobiography of the couple and the second part describing 179 different psychedelic compounds (most of which Shulgin discovered himself), including detailed synthesis instructions, bioassays, dosages, and other commentary. The second part was made freely available by Shulgin on Erowid while the first part is available only in the printed text. While the reactions described are beyond the ability of people with a basic chemistry education, some tend to emphasize techniques that do not require difficult-to-ob ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
By Mouth
Oral administration is a route of administration whereby a substance is taken through the Human mouth, mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications. Oral administration can be easier and less painful than other routes of administration, such as Injection (medicine), injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients able to swallow. Terminology ''Per os'' (; ''P.O.'') is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth". The expression is used in medicine to describe a treatment that is taken orally (but not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fennel
Fennel (''Foeniculum vulgare'') is a flowering plant species in the carrot family. It is a hardy, perennial herb with yellow flowers and feathery leaves. It is indigenous to the shores of the Mediterranean but has become widely naturalized in many parts of the world, especially on dry soils near the sea coast and on riverbanks. It is a highly flavorful herb used in cooking and, along with the similar-tasting anise, is one of the primary ingredients of absinthe. Florence fennel or finocchio (, , ) is a selection with a swollen, bulb-like stem base (sometimes called ''bulb fennel'') that is used as a vegetable. Description ''Foeniculum vulgare'' is a perennial herb. The stem is hollow, erect, and glaucous green, and it can grow up to tall. The leaves grow up to long; they are finely dissected, with the ultimate segments filiform (threadlike), about wide. Its leaves are similar to those of dill, but thinner. The flowers are produced in terminal compound umbels wid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Nervous System
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilateria, bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and Coelenterata, diploblasts. It is a structure composed of nervous tissue positioned along the Anatomical_terms_of_location#Rostral,_cranial,_and_caudal, rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain, though precursor structures exist in onychophorans, gastropods and lancelets. The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. Overview In vertebrates, the brain and spinal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulation
Stimulation is the encouragement of development or the cause of activity in general. For example, "The press provides stimulation of political discourse." An interesting or fun activity can be described as "stimulating", regardless of its physical effects on senses. ''Stimulate'' means to act as a stimulus to; ''stimulus'' means something that rouses the recipient to activity; ''stimuli'' is the plural of ''stimulus''. A particular use of the term is physiological stimulation, which refers to sensory excitation, the action of various agents or forms of energy (Stimulus (physiology), stimuli) on receptors that generate Action potential, impulses that travel through nerves to the brain (afferents). There are sensory receptors on or near the surface of the body, such as photoreceptors in the retina of the eye, hair cells in the cochlea of the ear, touch receptors in the skin and chemical receptors in the mouth and nasal cavity. There are also sensory receptors in the muscles, joints ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Study
Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, pharmaceutical drug, drugs, medical nutrition therapy, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received institutional review board, health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small Pilot experiment, pi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transform Press
Transform Press is a small publishing company in the area of psychedelics and other psychoactive drugs that is based in Berkeley, California.In Memoriam Ann Shulgin, Forerunner of Today’s Psychedelic Re-Emergence, Dies at 91. MAPS Bulletin: Special Edition, XXXII2. 2022. https://maps.org/wp-content/uploads/2022/11/AnnShulgin-MAPS-Bulletin-XXXII2-V1b-15.pdf It is the publisher of the books of Alexander Shulgin and Ann Shulgin and is led by Wendy Tucker, Ann Shulgin's daughter. The company's published books by the Shulgins include ''PiHKAL'' (''Phenethylamines I Have Known and Loved'') (1991), ''TiHKAL'' (''Tryptamines I Have Known and Loved'') (1997), ''The Shulgin Index'' (2011), ''The Simple Plant Isoquinolines'' (2002), and ''The Nature of Drugs'' (2021). They have also published ''Ergot Alkaloids: History, Chemistry, and Therapeutic Uses'' (2023), an English translation by Jitka Nykodemová of Albert Hofmann's 1964 book ''Die Mutterkornalkaloide: Vom Mutterkorn zum LSD'' (''Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alcohol (drug)
Alcohol, sometimes referred to by the chemical name ethanol, is the active ingredient in alcoholic drinks such as beer, wine, and distilled spirits (hard liquor). Alcohol is a central nervous system (CNS) depressant, decreasing Action potential, electrical activity of neurons in the brain, which causes the characteristic effects of alcohol intoxication ("drunkenness"). Among other effects, alcohol produces euphoria, anxiolytic, decreased anxiety, increased sociability, sedation, and impairment of cognitive, memory, motor control, motor, and sense, sensory function. Alcohol has a variety of adverse effects. Short-term effects of alcohol consumption, Short-term adverse effects include generalized impairment of neurocognitive function, dizziness, nausea, vomiting, and symptoms of hangover. Alcohol is addiction, addictive and can result in alcohol use disorder, Substance dependence, dependence, and Alcohol withdrawal syndrome, withdrawal upon cessation. The long-term effects of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substance Intoxication
Substance intoxication is a transient condition of altered consciousness and behavior associated with recent use of a substance. It is often maladaptive and impairing, but reversible. If the symptoms are severe, the term "substance intoxication delirium" may be used. Slang terms for the state include: getting ''high'' (generic), and being ''stoned'', ''cooked'', or ''fried'' (usually in reference to cannabis). Substance intoxication may often accompany a substance use disorder (SUD); if persistent substance-related problems exist, SUD is the preferred diagnosis. The term "intoxication" in common use most often refers to alcohol intoxication, or drug addiction usually opioids consisting of an overdose; resulting in death. Classification The ICD-10 ''Mental and Behavioural Disorders due to psychoactive substance use'' shows: * F10. alcohol * F11. opioids * F12. cannabinoids * F13. sedatives and hypnotics * F14. cocaine * F15. caffeine * F16. hallucinogens * F17. t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paresthesia
Paresthesia is a sensation of the skin that may feel like numbness (''hypoesthesia''), tingling, pricking, chilling, or burning. It can be temporary or Chronic condition, chronic and has many possible underlying causes. Paresthesia is usually painless and can occur anywhere on the body, but most commonly in the arms and legs. The most familiar kind of paresthesia is the sensation known as ''pins and needles'' after having a limb "fall asleep" (''obdormition''). A less common kind is formication, the sensation of insects crawling on the skin. Causes Transient Paresthesias of the hands, feet, legs, and arms are common transient symptoms. The briefest electric shock type of paresthesia can be caused by tweaking the ulnar nerve near the elbow; this phenomenon is colloquially known as bumping one's "funny bone". Similar brief shocks can be experienced when any other nerve is tweaked (e.g. a pinched neck nerve may cause a brief shock-like paresthesia toward the scalp). In the older a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
After-image
An afterimage, or after-image, is an image that continues to appear in the eyes after a period of exposure to the original image. An afterimage may be a normal phenomenon (physiological afterimage) or may be pathological (palinopsia). Illusory palinopsia may be a pathological exaggeration of physiological afterimages. Afterimages occur because photochemical activity in the retina continues even when the eyes are no longer experiencing the original stimulus. The remainder of this article refers to physiological afterimages. A common physiological afterimage is the dim area that seems to float before one's eyes after briefly looking into a light source, such as a camera flash. Palinopsia is a common symptom of visual snow. Negative afterimages Negative afterimages are generated in the retina but may be modified like other retinal signals by neural adaptation of the retinal ganglion cells that carry signals from the retina of the eye to the rest of the brain. Normally, any imag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diethyltryptamine
DET, also known under its chemical name ''N'',''N''-diethyltryptamine and as T-9, is a psychedelic drug closely related to DMT and 4-HO-DET. DET, alongside DMT, was placed into the UN Schedule 1 list of illegal drugs in the 1970s, and is uncommon now. Use DET is active at an oral dose of around 50 to 100mg and the effects last for about 2 to 4hours. Interactions Pharmacology Pharmacodynamics The mechanism of action of DET is thought to be serotonin receptor agonism, much like other classic psychedelics. It is a serotonin 5-HT2A receptor agonist. The drug produces the head-twitch response in rodents, a behavioral proxy of psychedelic-like effects. Pharmacokinetics Unlike DMT, DET is orally active as it is not subject to extensive metabolism by monoamine oxidase A. This may be due to the increased steric bulk of the N-ethyl substituents relative to the respective methyl groups of DMT. This is also true for many other tryptamines with larger nitrogen substituents. Ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
