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Paola Marignani
Paola A. Marignani is a scientist and Full Professor at Dalhousie University in the Faculty of Medicine, Department of Biochemistry and Molecular Biology. She is best known for her research on the tumor suppressor kinase LKB1, and its role in regulating the chromatin remodeling protein SMARCA4 and modeling metabolic processes in breast and lung cancers. Biography Marignani completed her Hon BSc in Biology from the University of Windsor, followed by an MSc in Neurobiology from the University of Western Ontario. She earned her PhD in Cell Biology from McMaster University. Her postdoctoral training took place at Harvard Medical School in the Division of Signal Transduction followed by the Lunenfeld-Tanenbaum Research Institute and the Ontario Cancer Institute in Toronto, Ontario. She also holds an Executive MBA from the Ivey School of Business at Western University, and a certificate from MIT Sloan School of Management in Artificial Intelligence in Health Care. Marignani is also a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactions. Though cells and other microscopic structures had been observed in living organisms as early as the 18th century, a detailed understanding of the mechanisms and interactions governing their behavior did not emerge until the 20th century, when technologies used in physics and chemistry had advanced sufficiently to permit their application in the biological sciences. The term 'molecular biology' was first used in 1945 by the English physicist William Astbury, who described it as an approach focused on discerning the underpinnings of biological phenomena—i.e. uncovering the physical and chemical structures and properties of biological molecules, as well as their interactions with other molecules and how these interactions explain observ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Estrogen Receptor
Estrogen receptors (ERs) are proteins found in cell (biology), cells that function as receptor (biochemistry), receptors for the hormone estrogen (17β-estradiol). There are two main classes of ERs. The first includes the intracellular estrogen receptors, namely ERα and ERβ, which belong to the nuclear receptor family. The second class consists of membrane estrogen receptors (mERs), such as GPER (GPR30), ER-X, and Gq-mER, Gq-mER, which are primarily G protein-coupled receptors. This article focuses on the nuclear estrogen receptors (ERα and ERβ). Upon activation by estrogen, intracellular ERs undergo protein targeting, translocation to the nucleus where they bind to specific DNA sequences. As DNA-binding transcription factors, they regulate the activity of various genes. However, ERs also exhibit functions that are independent of their DNA-binding capacity. These non-genomic actions contribute to the diverse effects of estrogen signaling in cells. Estrogen receptors (ERs) b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyunsaturated Fat
In biochemistry and nutrition, a polyunsaturated fat is a fat that contains a polyunsaturated fatty acid (abbreviated PUFA), which is a subclass of fatty acid characterized by a backbone with two or more carbon–carbon double bonds. Some polyunsaturated fatty acids are essentials. Polyunsaturated fatty acids are precursors to and are derived from polyunsaturated fats, which include drying oils. Nomenclature The position of the carbon-carbon double bonds in carboxylic acid chains in fats is designated by Greek letters. The carbon atom closest to the carboxyl group is the ''alpha'' carbon, the next carbon is the ''beta'' carbon and so on. In fatty acids the carbon atom of the methyl group at the end of the hydrocarbon chain is called the ''omega'' carbon because ''omega'' is the last letter of the Greek alphabet. Omega-3 fatty acids have a double bond three carbons away from the methyl carbon, whereas omega-6 fatty acids have a double bond six carbons away from the methyl car ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Signaling
In biology, cell signaling (cell signalling in British English) is the Biological process, process by which a Cell (biology), cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all Cell (biology), cellular life in both prokaryotes and eukaryotes. Typically, the signaling process involves three components: the signal, the receptor, and the effector. In biology, signals are mostly chemical in nature, but can also be physical cues such as pressure, Membrane potential, voltage, temperature, or light. Chemical signals are molecules with the ability to bind and activate a specific Receptor (biochemistry), receptor. These molecules, also referred to as Ligand (biochemistry), ligands, are chemically diverse, including ions (e.g. Na+, K+, Ca2+, etc.), lipids (e.g. steroid, prostaglandin), peptides (e.g. insulin, ACTH), carbohydrates, glycosylated proteins (proteoglycans), nucleic acids, etc. Peptide and lipid ligands are particularly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canadian Cancer Society
The Canadian Cancer Society () is Canada's largest national cancer charity and the largest national charitable funder of cancer research in Canada. History The Saskatchewan Medical Association formed Canada's first cancer committee in 1929, which established the first provincial Crown-funded, comprehensive cancer control program in the country. As this concept spread to other provinces, the CMA backed the original committee's proposal to establish a national organization called the Canadian Society for the Control of Cancer. The push was slow until, in 1935, the then-Governor General of Canada, the Earl of Bessborough, used his position to give it more momentum and created the King George V Silver Jubilee Cancer Fund for Canada to provide financial support. The National Study Committee recommended in 1937 the formation of a new organization, which was later called the Canadian Cancer Society for the Control of Cancer, which was created by letters patent, as the Canadian Cancer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canada Foundation For Innovation
The Canada Foundation for Innovation (CFI; , ''FCI'') is an independent corporation created by the Government of Canada to invest in research facilities and equipment in Canada's universities, colleges, research hospitals, and non-profit research institutions. Creation The CFI was created by the Government of Canada through the Budget Implementation Act 1997, Bill C-93, to "help build and sustain a research landscape in Canada that will attract and retain the world's top talent, train the next generation of researchers, support private-sector innovation and create high-quality jobs that strengthen Canada's position in today's knowledge economy". Funding The infrastructure funded by the CFI includes the equipment, laboratories, databases, specimens, scientific collections, computer hardware and software, communications linkages and buildings necessary to conduct research. The CFI has established a merit-review process that relies on experts from across Canada and around the world to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canadian Institutes Of Health Research
The Canadian Institutes of Health Research (CIHR; ; IRSC) is a federal agency responsible for funding health and medical research in Canada. Comprising 13 institutes, it is the successor to the Medical Research Council of Canada. CIHR supports more than 15,000 researchers and trainees through grants, fellowships, scholarships, and other funding, as part of the federal government's investment in health research. The peer review process is a vital part of CIHR. Review by panels of peers from the research community ensures that proposals approved for funding by CIHR meet internationally accepted standards of scientific excellence. Along with the Social Sciences and Humanities Research Council, and the Natural Sciences and Engineering Research Council, the CIHR forms the major source of federal government funding to post-secondary research and are collectively referred to as the "Tri-Council" or "Tri-Agency". History The Canadian Institutes of Health Research (CIHR) is the major ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Sciences And Engineering Research Council
The Natural Sciences and Engineering Research Council of Canada (NSERC; , CRSNG) is the major federal agency responsible for funding natural sciences and engineering research in Canada. NSERC directly funds university professors and students as well as Canadian companies to perform research and training. With funding from the Government of Canada, NSERC supports the research of over 41,000 students, trainees and professors at universities and colleges in Canada with an annual budget of CA$1.1 billion in 2015. Its current director is Alejandro Adem. NSERC, combined with the Social Sciences and Humanities Research Council (SSHRC) and the Canadian Institutes of Health Research (CIHR), forms the major source of federal government funding to post-secondary research. These bodies are sometimes collectively referred to as the "Tri-Council" or "Tri-Agency". History NSERC came into existence on 1 May 1978 under the ''Natural Sciences and Engineering Research Council Act'', which was pass ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer Canada
The breasts are two prominences located on the upper ventral region of the torso among humans and other primates. Both sexes develop breasts from the same embryology, embryological tissues. The relative size and development of the breasts is a major secondary sex distinction between females and males. There is also considerable Bra size, variation in size between individuals. Permanent Breast development, breast growth during puberty is caused by estrogens in conjunction with the growth hormone. Female humans are the only mammals that permanently develop breasts at puberty; all other mammals develop their mammary tissue during the latter period of pregnancy. In females, the breast serves as the mammary gland, which produces and secretes milk to feed infants. Subcutaneous fat covers and envelops a network of lactiferous duct, ducts that converge on the nipple, and these tissue (biology), tissues give the breast its distinct size and globular shape. At the ends of the ducts are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
