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POLR3C
DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the ''POLR3C'' gene. Interactions POLR3C has been shown to interact with GTF3C4 General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the ''GTF3C4'' gene. Interactions GTF3C4 has been shown to interact with GTF3C2, GTF3C1, POLR3C DNA-directed RNA polymerase III subunit RPC3 is an enzy .... Related gene problems * TAR syndrome * 1q21.1 deletion syndrome * 1q21.1 duplication syndrome References Further reading * * * * * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GTF3C4
General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the ''GTF3C4'' gene. Interactions GTF3C4 has been shown to interact with GTF3C2, GTF3C1, POLR3C and GTF3C5 General transcription factor 3C polypeptide 5 is a protein that in humans is encoded by the ''GTF3C5'' gene. Model organisms Model organisms have been used in the study of GTF3C5 function. A conditional knockout mouse line, called ''Gtf3c5tm2a .... References Further reading * * * * * {{gene-9-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecules known as product (chemistry), products. Almost all metabolism, metabolic processes in the cell (biology), cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme, pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are Ribozyme, catalytic RNA molecules, called ribozymes. Enzymes' Chemical specificity, specific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TAR Syndrome
TAR syndrome (thrombocytopenia with absent radius) is a rare genetic disorder that is characterized by the absence of the radius bone in the forearm and a dramatically reduced platelet count. Signs and symptoms * Presents with symptoms of thrombocytopenia, or a lowered platelet count, leading to bruising and potentially life-threatening hemorrhage. * Absence of the radius bone in the forearm with preservation of the thumb. Other common links between people with TAR syndrome include anemia, heart problems, kidney problems, knee joint problems, and frequently milk allergy. Different cases with leukemia in patients with TAR are described in. Genetics This condition requires mutations in both chromosomes.Brodie SA, Rodriguez-Aulet JP, Giri N, Dai J, Steinberg M, Waterfall JP, Roberson D, Ballew BJ, Zhou W, Anzick SL, Jiang Y, Wang Y, Zhu YJ, Meltzer PS, Boland J, Alter BP, Savage SA (2019) 1q21.1 deletion and a rare functional polymorphism in siblings with thrombocytopenia-absen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
